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In a seminal paper in 2013, Witt showed that the (1+1) Evolutionary Algorithm with standard bit mutation needs time $(1+o(1))n \ln n/p_1$ to find the optimum of any linear function, as long as the probability $p_1$ to flip exactly one bit…

神经与进化计算 · 计算机科学 2024-10-01 Carola Doerr , Duri Andrea Janett , Johannes Lengler

The basic reproduction ratio is a crucial threshold parameter in infectious disease models. In nonlocal dispersal systems, its variational characterization is challenging due to the possible absence of a principal eigenvalue caused by…

偏微分方程分析 · 数学 2026-05-27 Xiandong Lin , Jiazhuo Cheng , Qiru Wang

In this work we develop a microscopic physical model of early evolution, where phenotype,organism life expectancy, is directly related to genotype, the stability of its proteins in their native conformations which can be determined exactly…

生物大分子 · 定量生物学 2015-05-13 Konstantin Zeldovich , Peiqiu Chen , Boris Shakhnovich , Eugene Shakhnovich

We present a theoretical as well as experimental investigation of a population of self-replicating segments of code subject to random mutation and survival of the fittest. Under the assumption that such a system constitutes a minimal system…

adap-org · 物理学 2008-02-03 Chris Adami

We consider the evolution of populations under the joint action of mutation and differential reproduction, or selection. The population is modelled as a finite-type Markov branching process in continuous time, and the associated…

种群与进化 · 定量生物学 2009-02-23 Ellen Baake , Hans-Otto Georgii

We investigate the computational complexity of several basic linear algebra primitives, including largest eigenvector computation and linear regression, in the computational model that allows access to the data via a matrix-vector product…

机器学习 · 计算机科学 2021-05-25 Mark Braverman , Elad Hazan , Max Simchowitz , Blake Woodworth

We consider Evolution Strategies operating only with isotropic Gaussian mutations on positive quadratic objective functions, and investigate the covariance matrix when constructed out of selected individuals by truncation. We prove that the…

神经与进化计算 · 计算机科学 2019-10-29 Ofer M. Shir , Amir Yehudayoff

Growing efforts to measure fitness landscapes in molecular and microbial systems are premised on a tight relationship between landscape topography and evolutionary trajectories. This relationship, however, is far from being straightforward:…

种群与进化 · 定量生物学 2019-12-13 Matteo Smerlak

The emergence of a predominant phenotype within a cell population is often triggered by a rare accumulation of DNA mutations in a single cell. For example, tumors may be initiated by a single cell in which multiple mutations cooperate to…

组织与器官 · 定量生物学 2018-11-21 Philip Greulich , Benjamin D. Simons

The eigenvalue density for members of the Gaussian orthogonal and unitary ensembles follows the Wigner semi-circle law. If the Gaussian entries are all shifted by a constant amount c/Sqrt(2N), where N is the size of the matrix, in the large…

数学物理 · 物理学 2009-04-21 Kevin E. Bassler , Peter J. Forrester , Norman E. Frankel

Consider a mathematical model of evolutionary adaptation of fitness landscape and mutation matrix as a reaction to population changes. As a basis, we use an open quasispecies model, which is modified to include explicit death flow. We…

种群与进化 · 定量生物学 2020-11-25 Igor Samokhin , Tatiana Yakushkina , Alexander S. Bratus

For a class of processes modeling the evolution of a spatially structured population with migration and a logistic local regulation of the reproduction dynamics, we show convergence to an upper invariant measure from a suitable class of…

概率论 · 数学 2011-01-04 M. Hutzenthaler , A. Wakolbinger

In general or normal random matrix ensembles, the support of eigenvalues of large size matrices is a planar domain (or several domains) with a sharp boundary. This domain evolves under a change of parameters of the potential and of the size…

高能物理 - 理论 · 物理学 2007-05-23 R. Teodorescu , E. Bettelheim , O. Agam , A. Zabrodin , P. Wiegmann

Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process. As during carcinogenesis mutated genomes replicate according to their…

种群与进化 · 定量生物学 2009-12-15 B. Brutovsky , D. Horvath

This paper is concerned with the initial-boundary value problem for an evolutionary variational inequality complying with three intrinsic properties: complete irreversibility, unilateral equilibrium of an energy and an energy conservation…

偏微分方程分析 · 数学 2023-05-11 Goro Akagi , Kotaro Sato

In the evolutionary minority game, agents are allowed to evolve their strategies (``mutate'') based on past experience. We explore the dependence of the system's global behavior on the response time and the mutation threshold of the agents.…

统计力学 · 物理学 2009-11-10 Shahar Hod , Ehud Nakar

The maximum ${\log}_q$ likelihood estimation method is a generalization of the known maximum $\log$ likelihood method to overcome the problem for modeling non-identical observations (inliers and outliers). The parameter $q$ is a tuning…

统计方法学 · 统计学 2020-12-16 Mehmet Niyazi Çankaya , Roberto Vila

Random Hermitian matrices are used to model complex systems without time-reversal invariance. Adding an external source to the model can have the effect of shifting some of the matrix eigenvalues, which corresponds to shifting some of the…

数学物理 · 物理学 2015-05-20 Marco Bertola , Robert Buckingham , Seung-Yeop Lee , Virgil U. Pierce

Any organism is embedded in an environment that changes over time. The timescale for and statistics of environmental change, the precision with which the organism can detect its environment, and the costs and benefits of particular protein…

定量方法 · 定量生物学 2023-07-19 David A. Sivak , Matt Thomson

Modern ecology has re-emphasized the need for a quantitative understanding of the original 'survival of the fittest theme' based on analyzis of the intricate trade-offs between competing evolutionary strategies that characterize the…

种群与进化 · 定量生物学 2015-06-16 Jacopo Grilli , Samir Suweis , Amos Maritan