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We investigate via Monte Carlo numerical simulations and theoretical considerations the outflux of random walkers moving in an interval bounded by an interface exhibiting channels (pores, doors) which undergo an open/close cycle according…

数学物理 · 物理学 2014-01-16 Daniele Andreucci , Dario Bellaveglia , Emilio N. M. Cirillo , Silvia Marconi

Signals recorded from neurons with extracellular planar sensors have a wide range of waveforms and amplitudes. This variety is a result of different physical conditions affecting the ion currents through a cellular membrane. The…

The behaviour of a system of ion channels formed across the cell membrane is presented. The infinite number of channels with an infinite coupling is introduced first as a reference point for the detailed derivation of the…

生物物理 · 物理学 2007-05-23 Adam Rycerz

A model of mobile, charged ion channels in a fluid membrane is studied. The channels may switch between an open and a closed state according to a simple two-state kinetics with constant rates. The effective electrophoretic charge and the…

软凝聚态物质 · 物理学 2009-11-07 Stephan C. Kramer , Reiner Kree

We revisit the classical problem of diffusion-limited ion transport to a membrane (or electrode) by considering the effects of charged side walls. Using simple mathematical models and numerical simulations, we identify three basic…

流体动力学 · 物理学 2015-05-30 E. Victoria Dydek , Boris Zaltzman , Isaak Rubinstein , D. S. Deng , Ali Mani , Martin Z. Bazant

We use a one dimensional symmetric exclusion model to study pressure and osmosis driven flows through molecular-sized channels, such as biological membrane channels and zeolite pores. Analytic expressions are found for the steady-state flow…

软凝聚态物质 · 物理学 2008-02-03 Tom Chou

We discuss various models of ion transport through cell membrane channels. Recent experimental data shows that sizes of ion channels are compared to those of ions and that only few ions may be simultaneously in any single channel.…

亚细胞过程 · 定量生物学 2007-06-06 Jan Gomulkiewicz , Jacek Miekisz , Stanislaw Miekisz

The movement of ionic solutions is an essential part of biology and technology. Fluidics, from nano- to micro- to microfluidics, is a burgeoning area of technology which is all about the movement of ionic solutions, on various scales. Many…

定量方法 · 定量生物学 2018-06-08 Shixin Xu , Bob Eisenberg , Zilong Song , Huaxiong Huang

The paper studies homeostatic ion channel trafficking in neurons. We derive a nonlinear closed-loop model that captures active transport with degradation, channel insertion, average membrane potential activity, and integral control. We…

亚细胞过程 · 定量生物学 2019-09-13 Saeed Aljaberi , Timothy O'Leary , Fulvio Forni

Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model. The enhancement occurs in a finite…

生物物理 · 物理学 2007-05-23 Michael J. Barber , Manfred L. Ristig

A model of mobile, charged ion channels embedded in a biomembrane is investigated. The ion channels fluctuate between an opened and a closed state according to a simple two-state reaction scheme whereas the total number of ion channels is a…

斑图形成与孤子 · 物理学 2009-11-11 Ronny Peter , Walter Zimmermann

Transport of molecules across membrane channels is investigated theoretically using exactly solvable discrete stochastic site-binding models. It is shown that the interaction potential between molecules and the channel has a strong effect…

软凝聚态物质 · 物理学 2009-11-11 Anatoly B. Kolomeisky

The transport and dispersion of multiple species of charged ions are central to many biological and physical processes, including electrokinetic ion separation. However, most theoretical studies of dispersion in channels have focused on…

软凝聚态物质 · 物理学 2026-05-04 Thakurdas Mahata , Anirban Chatterjee , Ameeya Kumar Nayak

In this article we address the study of ion charge transport in the biological channels separating the intra and extracellular regions of a cell. The focus of the investigation is devoted to including thermal driving forces in the…

数值分析 · 数学 2015-04-24 Riccardo Sacco , Fabio Manganini , Joseph W. Jerome

Transmembrane ion flow through channel proteins undergoing density fluctuations may cause lateral gradients of the electrical potential across the membrane giving rise to electrophoresis of charged channels. A model for the dynamics of the…

斑图形成与孤子 · 物理学 2009-11-11 Markus Hilt , Walter Zimmermann

We consider processes that coincide with a given diffusion process except on the boundaries of a finite collection of domains. The behavior on each of the boundaries is asymmetric: the process is much more likely to enter the interior of…

概率论 · 数学 2020-03-18 Mark Freidlin , Leonid Koralov

The flow of micropolar fluid through a membrane modeled as a swarm of solid cylindrical particles with porous layer using the cell model technique is considered. The flow is directed perpendicular to the axis of the cylinders. Boundary…

流体动力学 · 物理学 2019-09-04 D. Yu. Khanukaeva , A. N. Filippov , P. K. Yadav , A. Tiwari

We consider the diffusion-advection problem in two simple cellular flow models (often invoked as examples for subdiffusive tracer's motion) and concentrate on the intermediate time range, in which the tracer's motion indeed may show…

流体动力学 · 物理学 2016-09-28 Patrick Pöschke , Igor M. Sokolov , Alexander A. Nepomnyashchy , Michael A. Zaks

Ion transport in biological tissues is crucial in the study of many biological and pathological problems. Some multi-cellular structures, like smooth muscles on the vessel walls, could be treated as periodic bi-domain structures, which…

偏微分方程分析 · 数学 2021-03-11 Chun Xiao , Xingye Yue , Huaxiong Huang , Shixin Xu

The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles. The mechanism of…

细胞行为 · 定量生物学 2015-05-30 D. Andreucci , D. Bellaveglia , E. N. M. Cirillo , S. Marconi
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