相关论文: Modeling the modulation of neuronal bursting: a si…

We study spatio-temporal bursting in a three-scale reaction diffusion equation organized by the winged cusp singularity. For large time-scale separation the model exhibits traveling bursts, whereas for large space-scale separation the model…

Bursting is a phenomenon found in a variety of physical and biological systems. For example, in neuroscience, bursting is believed to play a key role in the way information is transferred in the nervous system. In this work, we propose a…

Mutual inhibition is a common motif in neural systems. Here, we establish that cusped singularities - folded singularities located at cusp points of critical manifolds - provide a universal organizing mechanism for mixed-mode oscillations…

We describe a simple conductance-based model neuron that includes intra- and extra-cellular ion concentration dynamics and show that this model exhibits periodic bursting. The bursting arises as the fast spiking behavior of the neuron is…

Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that…

Modeling and parameter estimation for neuronal dynamics are often challenging because many parameters can range over orders of magnitude and are difficult to measure experimentally. Moreover, selecting a suitable model complexity requires a…

A simple model that replicates the dynamics of spiking and spiking-bursting activity of real biological neurons is proposed. The model is a two-dimensional map which contains one fast and one slow variable. The mechanisms behind generation…

Currently we routinely develop a complex neuronal network to explain observed but often paradoxical phenomena based upon biological recordings. Here we present a general approach to demonstrate how to mathematically tackle such a complex…

The brain can learn to solve a wide range of tasks with high temporal and energetic efficiency. However, most biological models are composed of simple single compartment neurons and cannot achieve the state-of-art performances of artificial…

Neuronal spiking exhibits an exquisite combination of modulation and robustness properties, rarely matched in artificial systems. We exploit the particular interconnection structure of conductance based models to investigate this remarkable…

We study a simple map as a minimal model of excitable cells. The map has two fast variables which mimic the behavior of class I neurons, undergoing a sub-critical Hopf bifurcation. Adding a third slow variable allows the system to present…

Real cortical tissue curves and folds according to experimental data. However, our current simulations only use unfolded cortical layers. This project extends the cortical slice model in order to be able to specify arbitrary curvatures to…

This paper proposes a framework for the biological learning mechanism as a general learning system. The proposal is as follows. The bursting and tonic modes of firing patterns found in many neuron types in the brain correspond to two…

This paper proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the…

We report a detailed analysis on the emergence of bursting in a recently developed neural mass model that takes short-term synaptic plasticity into account. The one being used here is particularly important, as it represents an exact…

Cultures of neurons grown on multi-electrode arrays have become a common experimental preparation for investigating developing neural networks. Experiment and simulation have shown that these developing networks eventually exhibit bursting…

The paper concerns with Wilson-Cowan neural model with impulses. The main novelty of the study is that besides the traditional singularity of the model, we consider singular impulses. A new technique of analysis of the phenomenon is…

Network architecture forms a critical constraint on neuronal function. Here we examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal…

In the absence of inhibition, excitatory neuronal networks can alternate between bursts and interburst intervals (IBI), with heterogeneous length distributions. As this dynamic remains unclear, especially the durations of each epoch, we…

Characterising the representation of sensory stimuli in the brain is a fundamental scientific endeavor, which can illuminate principles of information coding. Most characterizations reduce the dimensionality of neural data by converting…