相关论文: Immune networks: multi-tasking capabilities near s…

We propose a new method to immunize populations or computer networks against epidemics which is more efficient than any method considered before. The novelty of our method resides in the way of determining the immunization targets. First we…

Many complex systems can be represented as networks composed by distinct layers, interacting and depending on each others. For example, in biology, a good description of the full protein-protein interactome requires, for some organisms, up…

Time-limited states characterise many dynamical processes on networks: disease infected individuals recover after some time, people forget news spreading on social networks, or passengers may not wait forever for a connection. These…

A coupled cell network describes interacting (coupled) individual systems (cells). As in networks from real applications, coupled cell networks can represent inhomogeneous networks where different types of cells interact with each other in…

We consider the multitasking associative network in the low-storage limit and we study its phase diagram with respect to the noise level $T$ and the degree $d$ of dilution in pattern entries. We find that the system is characterized by a…

Understanding the dependence and interplay between architecture and function in biological networks has great relevance to disease progression, biological fabrication and biological systems in general. We propose methods to assess the…

The composition of a polyclonal antibody response is hard to measure experimentally but contains vital information about the robustness of immunity. Here, we argue that the statistics of neutralization titers alone can be used to make…

In many real-world complex systems, individuals have many kind of interactions among them, suggesting that it is necessary to consider a layered structure framework to model systems such as social interactions. This structure can be…

The contact structure of a population plays an important role in transmission of infection. Many ``structured models'' capture aspects of the contact structure through an underlying network or a mixing matrix. An important observation in…

In the context of network data, bipartite networks are of particular interest, as they provide a useful description of systems representing relationships between sending and receiving nodes. In this framework, we extend the Mixture of…

Metabolic networks play a crucial role in biology since they capture all chemical reactions in an organism. While there are networks of high quality for many model organisms, networks for less studied organisms are often of poor quality and…

The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development,…

A more connected world has brought major consequences such as facilitate the spread of diseases all over the world to quickly become epidemics, reason why researchers are concentrated in modeling the propagation of epidemics and outbreaks…

Our work is motivated by and illustrated with application of association networks in computational biology, specifically in the context of gene/protein regulatory networks. Association networks represent systems of interacting elements,…

Recently, research that focuses on the rigorous understanding of the relation between simulation and/or exact models on graphs and approximate counterparts has gained lots of momentum. This includes revisiting the performance of classic…

Mathematical models of infectious diseases, which are in principle analytically tractable, use two general approaches. The first approach, generally known as compartmental modeling, addresses the time evolution of disease propagation at the…

The study of spreading processes often analyzes networks at different resolutions, e.g., at the level of individuals or countries, but it is not always clear how properties at one resolution can carry over to another. Accordingly, in this…

Following antigen stimulation, the net outcomes of a T cell response are shaped by integrated signals from both positive co-stimulatory and negative regulatory molecules. Recently, the blockade of negative regulatory molecules (i.e. immune…

In this paper, a system architecture is proposed that approximately models the functionality of metabolic networks. The AND/OR graph model is used to represent the metabolic network and each processing element in the system emulates the…

A stochastic reaction-diffusion model is studied on a networked support. In each patch of the network two species are assumed to interact following a non-normal reaction scheme. When the interaction unit is replicated on a directed linear…