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This paper presents efficient algorithms for solving the problem of aligning a protein structure template to a query amino-acid sequence, known as protein threading problem. We consider the problem as a special case of graph matching…

定量方法 · 定量生物学 2007-05-23 Nicola Yanev , Rumen Andonov , Philippe Veber , Stefan Balev

Aligning protein interaction networks (PPI) of two or more organisms consists of finding a mapping of the nodes (proteins) of the networks that captures important structural and functional associations (similarity). It is a well studied but…

分子网络 · 定量生物学 2020-10-12 Concettina Guerra , Pietro Hiram Guzzi

Feature selection is an important and active research area in statistics and machine learning. The Elastic Net is often used to perform selection when the features present non-negligible collinearity or practitioners wish to incorporate…

机器学习 · 统计学 2020-06-09 Tobia Boschi , Matthew Reimherr , Francesca Chiaromonte

Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use…

分子网络 · 定量生物学 2009-10-08 Oleksii Kuchaiev , Tijana Milenkovic , Vesna Memisevic , Wayne Hayes , Natasa Przulj

Motivated by a variety of applications in control engineering and information sciences, we study network resource allocation problems where the goal is to optimally allocate a fixed amount of resource over a network of nodes. In these…

最优化与控制 · 数学 2017-08-25 Thinh T. Doan , Carolyn L. Beck

Motivated by broad applications in various fields of engineering, we study a network resource allocation problem where the goal is to optimally allocate a fixed quantity of resources over a network of nodes. We consider large scale networks…

最优化与控制 · 数学 2018-08-06 Thinh T. Doan , Carolyn L. Beck

Graph matching is a challenging problem with very important applications in a wide range of fields, from image and video analysis to biological and biomedical problems. We propose a robust graph matching algorithm inspired in…

最优化与控制 · 数学 2013-11-26 Marcelo Fiori , Pablo Sprechmann , Joshua Vogelstein , Pablo Musé , Guillermo Sapiro

Background: In Kreuz et al., J Neurosci Methods 381, 109703 (2022) two methods were proposed that perform latency correction, i.e., optimize the spike time alignment of sparse neuronal spike trains with well defined global spiking events.…

Dual decomposition, and more generally Lagrangian relaxation, is a classical method for combinatorial optimization; it has recently been applied to several inference problems in natural language processing (NLP). This tutorial gives an…

计算与语言 · 计算机科学 2014-05-21 Alexander M. Rush , Michael Collins

PPI network alignment aims to find topological and functional similarities between networks of different species. Several alignment approaches have been proposed. Each of these approaches relies on a different alignment method and uses…

定量方法 · 定量生物学 2019-11-25 Sarra Ghanjeti

We face network data from various sources, such as protein interactions and online social networks. A critical problem is to model network interactions and identify latent groups of network nodes. This problem is challenging due to many…

机器学习 · 计算机科学 2012-02-20 Feng Yan , Zenglin Xu , Yuan , Qi

Network alignment (NA) aims to find regions of similarities between molecular networks of different species. There exist two NA categories: local (LNA) or global (GNA). LNA finds small highly conserved network regions and produces a…

分子网络 · 定量生物学 2015-09-30 Lei Meng , Aaron Striegel , Tijana Milenkovic

Network slicing is a key technique in 5G and beyond for efficiently supporting diverse services. Many network slicing solutions rely on deep learning to manage complex and high-dimensional resource allocation problems. However, deep…

网络与互联网体系结构 · 计算机科学 2024-01-23 Tianlun Hu , Qi Liao , Qiang Liu , Antonio Massaro , Georg Carle

Complex networks are frequently employed to model physical or virtual complex systems. When certain entities exist across multiple systems simultaneously, unveiling their corresponding relationships across the networks becomes crucial. This…

物理与社会 · 物理学 2025-04-16 Rui Tang , Ziyun Yong , Shuyu Jiang , Xingshu Chen , Yaofang Liu , Yi-Cheng Zhang , Gui-Quan Sun , Wei Wang

The alignment of biological networks has the potential to teach us as much about biology and disease as has sequence alignment. Sequence alignment can be optimally solved in polynomial time. In contrast, network alignment is $NP$-hard,…

分子网络 · 定量生物学 2016-07-12 Nil Mamano , Wayne Hayes

The sparse nonlinear programming (SNP) problem has wide applications in signal and image processing, machine learning, pattern recognition, finance and management, etc. However, the computational challenge posed by SNP has not yet been well…

最优化与控制 · 数学 2021-05-26 Chen Zhao , Naihua Xiu , Hou-Duo Qi , Ziyan Luo

Network pruning is a widely used technique to reduce computation cost and model size for deep neural networks. However, the typical three-stage pipeline significantly increases the overall training time. In this paper, we develop a…

神经与进化计算 · 计算机科学 2023-04-11 Shanglin Zhou , Mikhail A. Bragin , Lynn Pepin , Deniz Gurevin , Fei Miao , Caiwen Ding

Sequence alignment has had an enormous impact on our understanding of biology, evolution, and disease. The alignment of biological {\em networks} holds similar promise. Biological networks generally model interactions between biomolecules…

分子网络 · 定量生物学 2019-11-25 Wayne B. Hayes

We introduce a novel approach addressing global analysis of a difficult class of nonconvex-nonsmooth optimization problems within the important framework of Lagrangian-based methods. This genuine nonlinear class captures many problems in…

最优化与控制 · 数学 2018-01-10 Jérôme Bolte , Shoham Sabach , Marc Teboulle

Our Microbiome Network Alignment Algorithm (MiNAA) aligns two microbial networks using a combination of the GRAph ALigner (GRAAL) algorithm and the Hungarian algorithm. Network alignment algorithms find pairs of nodes (one node from the…

分子网络 · 定量生物学 2022-12-13 Reed Nelson , Rosa Aghdam , Claudia Solis-Lemus
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