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Microbial populations adapt to their environment by acquiring advantageous mutations, but in the early twentieth century, questions about how these organisms acquire mutations arose. The experiment of Salvador Luria and Max Delbr\"uck that…

种群与进化 · 定量生物学 2021-06-24 Stephen Montgomery-Smith , Hesam Oveys

We analyze here different types of fractional differential equations, under the assumption that their fractional order $\nu \in (0,1] $ is random\ with probability density $n(\nu).$ We start by considering the fractional extension of the…

概率论 · 数学 2015-05-27 Luisa Beghin

Accurately selecting and estimating smooth functional effects in additive models with potentially many functions is a challenging task. We introduce a novel Demmler-Reinsch basis expansion to model the functional effects that allows us to…

统计方法学 · 统计学 2024-01-02 Paul Bach , Nadja Klein

Predicting time-to-event outcomes in large databases can be a challenging but important task. One example of this is in predicting the time to a clinical outcome for patients in intensive care units (ICUs), which helps to support critical…

统计计算 · 统计学 2019-08-06 Yingying Xu , Joon Lee , Joel A. Dubin

Real-world data often exhibits sequential dependence, across diverse domains such as human behavior, medicine, finance, and climate modeling. Probabilistic methods capture the inherent uncertainty associated with prediction in these…

机器学习 · 统计学 2024-03-08 Alex Boyd

The likelihood-free sequential Approximate Bayesian Computation (ABC) algorithms, are increasingly popular inference tools for complex biological models. Such algorithms proceed by constructing a succession of probability distributions over…

统计计算 · 统计学 2012-10-12 Daniel Silk , Saran Filippi , Michael P. H. Stumpf

In the context of survival analysis, Marshall and Olkin (1997) introduced families of distributions by adding a scalar parameter to a given survival function, parameterized or not. In that paper, we generalize their approach. We show how it…

统计方法学 · 统计学 2011-07-21 Damien Bousquet , Jean-Pierre Daurès , Jean-Michel Marin

Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health…

We propose an extension of the Cox-Ross-Rubinstein (CRR) model based on $q$-binomial (or Kemp) random walks, with application to default with logistic failure rates. This model allows us to consider time-dependent switching probabilities…

证券定价 · 定量金融 2023-02-07 Jean-Christophe Breton , Youssef El-Khatib , Jun Fan , Nicolas Privault

A Systematic Evolution of Ligands by EXponential enrichment (SELEX) experiment begins in round one with a random pool of oligonucleotides in equilibrium solution with a target. Over a few rounds, oligonucleotides having a high affinity for…

Survival analysis is a type of semi-supervised ranking task where the target output (the survival time) is often right-censored. Utilizing this information is a challenge because it is not obvious how to correctly incorporate these censored…

机器学习 · 计算机科学 2018-06-12 Margaux Luck , Tristan Sylvain , Joseph Paul Cohen , Heloise Cardinal , Andrea Lodi , Yoshua Bengio

Modeling the evolution of a financial index as a stochastic process is a problem awaiting a full, satisfactory solution since it was first formulated by Bachelier in 1900. Here it is shown that the scaling with time of the return…

统计金融 · 定量金融 2009-11-13 Attilio L. Stella , Fulvio Baldovin

We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials exploiting some subjects' previous assessed responses. Subjects arrive sequentially and…

统计方法学 · 统计学 2021-06-03 Adam Kapelner , Abba Krieger

In observational studies, treatment may be adapted to covariates at several times without a fixed protocol, in continuous time. Treatment influences covariates, which influence treatment, which influences covariates, and so on. Then even…

统计理论 · 数学 2015-09-02 Judith J. Lok

Dzhaparidze and Spreij [5] showed that the quadratic variation of a semimartingale can be approximated using a randomized periodogram. We show that the same approximation is valid for a special class of continuous stochastic processes. This…

概率论 · 数学 2012-03-07 Ehsan Azmoodeh , Esko Valkeila

Complex behaviour in many systems arises from the stochastic interactions of spatially distributed particles or agents. Stochastic reaction-diffusion processes are widely used to model such behaviour in disciplines ranging from biology to…

统计力学 · 物理学 2016-08-23 David Schnoerr , Ramon Grima , Guido Sanguinetti

We propose a general approach for encouraging fairness in survival analysis models based on minimizing a worst-case error across all subpopulations that occur with at least a user-specified probability. This approach can be used to convert…

机器学习 · 统计学 2024-09-18 Shu Hu , George H. Chen

Einstein's explanation of Brownian motion provided one of the cornerstones which underlie the modern approaches to stochastic processes. His approach is based on a random walk picture and is valid for Markovian processes lacking long-term…

统计力学 · 物理学 2009-11-10 I. M. Sokolov , J. Klafter

Cox proportional hazard regression model is a popular tool to analyze the relationship between a censored lifetime variable with other relevant factors. The semi-parametric Cox model is widely used to study different types of data arising…

统计方法学 · 统计学 2018-10-09 Abhik Ghosh , Ayanendranath Basu

We consider the task of modeling a dependent sequence of random partitions. It is well-known that a random measure in Bayesian nonparametrics induces a distribution over random partitions. The community has therefore assumed that the best…

统计方法学 · 统计学 2021-08-03 Garritt L. Page , Fernando A. Quintana , David B. Dahl