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Cells move by run and tumble, a kind of dynamics in which the cell alternates runs over straight lines and re-orientations. This erratic motion may be influenced by external factors, like chemicals, nutrients, the extra-cellular matrix, in…

细胞行为 · 定量生物学 2019-07-02 Nadia Loy , Luigi Preziosi

Many cell types display random motility on two-dimensional substrates, but crawl persistently in a single direction when confined in a microchannel or on an adhesive micropattern. Does this imply that the motility mechanism of confined…

生物物理 · 物理学 2014-06-13 Brian A. Camley , Wouter-Jan Rappel

Self-activation coupled to a transport mechanism results in traveling waves that describe polymerization reactions, forest fires, tumor growth, and even the spread of epidemics. Diffusion is a simple and commonly used model of particle…

统计力学 · 物理学 2020-07-06 Keisuke Ishihara , Ashish B. George , Ryan Cornelius , Kirill S. Korolev

Constructing physical models of living cells and tissues is an extremely challenging task because of the high complexities of both intra- and intercellular processes. In addition, the force that a single cell generates vanishes in total due…

软凝聚态物质 · 物理学 2019-05-09 Mitsusuke Tarama , Kenji Mori , Ryoichi Yamamoto

Many-body quantum-mechanical stationary states that have real valued wavefunctions are shown to satisfy a classical conservation of energy equation with a kinetic energy function. The terms in the equation depend on the probability…

原子物理 · 物理学 2021-07-23 James P. Finley

Most models designed to study the bidirectional movement of cargos as they are driven by molecular motors rely on the idea that motors of different polarities can be coordinated by external agents if arranged into a motor-cargo complex to…

生物物理 · 物理学 2010-06-29 Carla Goldman

Multiple experiments show that various submicron particles such as magnetosomes, RNA messengers, viruses, and even much smaller nanoparticles such as globular proteins diffuse anomalously slow in viscoelastic cytosol of living cells. Hence,…

生物物理 · 物理学 2018-11-12 Igor Goychuk

Flocking and vortical are two typical motion modes in active matter. Although it is known that the two modes can spontaneously switch between each other in a finite-size system, the switching dynamics remain elusive. In this work, by…

软凝聚态物质 · 物理学 2024-08-20 Bing Yang , Yanting Wang

The motility of a fish keratocyte on a flat substrate exhibits two distinct regimes: the non-migrating and the migrating one. In both configurations the shape is fixed in time and, when the cell is moving, the velocity is constant in…

细胞行为 · 定量生物学 2016-06-29 Davide Ambrosi , Anna Zanzottera

We consider random walks on quasi one dimensional lattices, as introduced in \cite{FS}. This mathematical setting covers a large class of discrete kinetic models for non-cooperative molecular motors on periodic tracks. We derive general…

概率论 · 数学 2015-06-19 Alessandra Faggionato , Vittoria Silvestri

We consider a minimal go-or-grow model of cell invasion, whereby cells can either proliferate, following logistic growth, or move, via linear diffusion, and phenotypic switching between these two states is density-dependent. Formal analysis…

偏微分方程分析 · 数学 2024-04-18 Carles Falcó , Rebecca M. Crossley , Ruth E. Baker

The paper presents bifurcation behavior of a single phase induction motor. This paper also attempts to discuss the bifurcation behavior of the system based on the evolution of different state variables. The bifurcation diagrams drawn…

混沌动力学 · 物理学 2017-07-26 Krishnendu Chakrabarty , Urmila Kar

The traffic of molecular motors which interact through mutual exclusion is studied theoretically for half-open tube-like compartments. These half-open tubes mimic the shapes of axons. The mutual exclusion leads to traffic jams or density…

统计力学 · 物理学 2007-05-23 Melanie J. I. Muller , Stefan Klumpp , Reinhard Lipowsky

Molecular machines transduce free energy between different forms throughout all living organisms. While truly machines in their own right, unlike their macroscopic counterparts molecular machines are characterized by stochastic…

统计力学 · 物理学 2025-06-13 Matthew P. Leighton , David A. Sivak

A minimal design for a molecular swimmer is proposed that is a based on a mechanochemical propulsion mechanism. Conformational changes are induced by electrostatic actuation when specific parts of the molecule temporarily acquire net…

生物物理 · 物理学 2015-05-19 Ramin Golestanian

A novel mechanism of reaction-induced active molecular motion, not involving any kind of self-propulsion, is proposed and analyzed. Because of the momentum exchange with the surrounding solvent, conformational transitions in…

软凝聚态物质 · 物理学 2023-04-19 Hiroyuki Kitahata , Alexander S. Mikhailov

We propose a model for motor proteins based on a hierarchical Hamiltonian that we have previously introduced to describe protein folding. The proposed motor model has high efficiency and is consistent with a linear load-velocity response.…

凝聚态物理 · 物理学 2009-10-31 Alex Hansen , Mogens H. Jensen , Kim Sneppen , Giovanni Zocchi

The bacterial flagellar motor plays a crucial role in both bacterial locomotion and chemotaxis. Recent experiments reveal that the switching dynamics of the motor depends on the motor rotation speed, and thus the motor torque,…

生物物理 · 物理学 2013-07-26 Fan Bai , Tohru Minamino , Zhanghan Wu , Keiichi Namba , Jianhua Xing

Cell movement has essential functions in development, immunity and cancer. Various cell migration patterns have been reported and a general rule has recently emerged, the so-called UCSP (Universal Coupling between cell Speed and cell…

偏微分方程分析 · 数学 2019-12-17 Christèle Etchegaray , Nicolas Meunier , Raphael Voituriez

A discrete-state model of the F1-ATPase molecular motor is developed which describes not only the dependences of the rotation and ATP consumption rates on the chemical concentrations of ATP, ADP, and inorganic phosphate, but also on…

亚细胞过程 · 定量生物学 2009-04-28 E. Gerritsma , P. Gaspard