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Bayesian inference methods rely on numerical algorithms for both model selection and parameter inference. In general, these algorithms require a high computational effort to yield reliable estimates. One of the major challenges in…

定量方法 · 定量生物学 2018-08-09 Patricio Maturana , Brendon J. Brewer , Steffen Klaere , Remco Bouckaert

Image-text matching is an interesting and fascinating task in modern AI research. Despite the evolution of deep-learning-based image and text processing systems, multi-modal matching remains a challenging problem. In this work, we consider…

计算机视觉与模式识别 · 计算机科学 2021-01-27 Nicola Messina , Fabrizio Falchi , Andrea Esuli , Giuseppe Amato

High-throughput sequencing (HTS) is revolutionizing biological research by enabling scientists to quickly and cheaply query variation at a genomic scale. Despite the increasing ease of obtaining such data, using these data effectively still…

基因组学 · 定量生物学 2012-11-09 Sonal Singhal

Phylogenetic networks have gained prominence over the years due to their ability to represent complex non-treelike evolutionary events such as recombination or hybridization. Popular combinatorial objects used to construct them are triplet…

组合数学 · 数学 2016-10-19 P. Gambette , K. T. Huber , S. Kelk

Robust tensor completion (RTC) aims to recover a low-rank tensor from its incomplete observation with outlier corruption. The recently proposed tensor ring (TR) model has demonstrated superiority in solving the RTC problem. However, the…

机器学习 · 计算机科学 2023-02-16 Zhenhao Huang , Yuning Qiu , Xinqi Chen , Weijun Sun , Guoxu Zhou

Multi-Task Learning (MTL) has shown its importance at user products for fast training, data efficiency, reduced overfitting etc. MTL achieves it by sharing the network parameters and training a network for multiple tasks simultaneously.…

机器学习 · 计算机科学 2022-12-08 Brijraj Singh , Swati Gupta , Mayukh Das , Praveen Doreswamy Naidu , Sharan Kumar Allur

Motif finding in DNA, RNA and proteins plays an important role in life science research. Recent patents concerning motif finding in the biomolecular data are recorded in the DNA Patent Database which serves as a resource for policy makers…

计算工程、金融与科学 · 计算机科学 2017-01-03 Kevin Byron , Jason T. L. Wang

Motivation: Millions of genes in the modern species belong to only thousands of `gene families'. A gene family includes instances of the same gene in different species (orthologs) and duplicate genes in the same species (paralogs). Genes…

种群与进化 · 定量生物学 2012-05-04 Yu Zheng , Taoyang Wu , Louxin Zhang

Nested sampling (NS) computes parameter posterior distributions and makes Bayesian model comparison computationally feasible. Its strengths are the unsupervised navigation of complex, potentially multi-modal posteriors until a well-defined…

统计计算 · 统计学 2023-07-11 Johannes Buchner

Tanglegrams are a special class of graphs appearing in applications concerning cospeciation and coevolution in biology and computer science. They are formed by identifying the leaves of two rooted binary trees. We give an explicit formula…

组合数学 · 数学 2015-07-20 Sara Billey , Matjaž Konvalinka , Frederick A Matsen

The general trace reconstruction problem seeks to recover an original sequence from its noisy copies independently corrupted by deletions, insertions, and substitutions. This problem arises in applications such as DNA data storage, a…

机器学习 · 计算机科学 2025-07-18 Franziska Weindel , Michael Girsch , Reinhard Heckel

RNA's diverse biological functions stem from its structural versatility, yet accurately predicting and designing RNA sequences given a 3D conformation (inverse folding) remains a challenge. Here, I introduce a deep learning framework that…

定量方法 · 定量生物学 2026-01-06 Annabelle Yao

Circular RNAs (circRNAs) are important components of the non-coding RNA regulatory network. Previous circRNA identification primarily relies on high-throughput RNA sequencing (RNA-seq) data combined with alignment-based algorithms that…

机器学习 · 计算机科学 2025-07-14 Tianyou Jiang

We introduce a deep residual recurrent neural network (DR-RNN) as an efficient model reduction technique for nonlinear dynamical systems. The developed DR-RNN is inspired by the iterative steps of line search methods in finding the residual…

计算工程、金融与科学 · 计算机科学 2017-09-05 J. Nagoor Kani , Ahmed H. Elsheikh

Computational protein design has the potential to deliver novel molecular structures, binders, and catalysts for myriad applications. Recent neural graph-based models that use backbone coordinate-derived features show exceptional…

生物大分子 · 定量生物学 2022-04-28 Alex J. Li , Vikram Sundar , Gevorg Grigoryan , Amy E. Keating

Standard ChIP-seq peak calling pipelines seek to differentiate biochemically reproducible signals of individual genomic elements from background noise. However, reproducibility alone does not imply functional regulation (e.g., enhancer…

We present TripNet, a method for constructing phylogenetic networks from triplets. We will present the motivations behind our approach and its theoretical and empirical justification. To demonstrate the accuracy and efficiency of TripNet,…

计算工程、金融与科学 · 计算机科学 2015-03-19 Ruzbeh Tusserkani , Changiz Eslahchi , Hadi Poormohammadi , Azin Azadi

The study of deep neural networks (DNNs) in the infinite-width limit, via the so-called neural tangent kernel (NTK) approach, has provided new insights into the dynamics of learning, generalization, and the impact of initialization. One key…

机器学习 · 计算机科学 2021-06-16 Sina Alemohammad , Zichao Wang , Randall Balestriero , Richard Baraniuk

We propose a new neural network framework, termed Neural Network Machine Regression (NNMR), which integrates trainable input gating and adaptive depth regularization to jointly perform feature selection and function estimation in an…

统计方法学 · 统计学 2026-02-03 Jiuchen Zhang , Ling Zhou , Peter Song

We present a new method to detect duplicates used to merge different bibliographic record corpora with the help of lexical and social information. As we show, a trivial key is not available to delete useless documents. Merging heteregeneous…

数据库 · 计算机科学 2015-04-29 Nicolas Turenne