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At the level of individual neurons, various coding properties can be inferred from the input-output relationship of a cell. For small inputs, this relation is captured by the phase-response curve (PRC), which measures the effect of a small…

神经元与认知 · 定量生物学 2026-01-14 Janina Hesse , Susanne Schreiber

The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both model data and…

定量方法 · 定量生物学 2010-03-29 Benjamin Torben-Nielsen , Marylka Uusisaari , Klaus M. Stiefel

The phase response curve (PRC) is an important measure representing the interaction between oscillatory elements. To understand synchrony in biological systems, many research groups have sought to measure PRCs directly from biological cells…

定量方法 · 定量生物学 2015-08-03 Kazuhiko Morinaga , Ryota Miyata , Toru Aonishi

Synchronized neural spiking is associated with many cognitive functions and thus, merits study for its own sake. The analysis of neural synchronization naturally leads to the study of repetitive spiking and consequently to the analysis of…

神经元与认知 · 定量生物学 2017-07-19 Youngmin Park , Stewart Heitmann , G. Bard Ermentrout

Phase response curve (PRC) is an extremely useful tool for studying the response of oscillatory systems, e.g. neurons, to sparse or weak stimulation. Here we develop a framework for studying the response to a series of pulses which are…

数据分析、统计与概率 · 物理学 2017-09-13 Vladimir Klinshov , Serhiy Yanchuk , Artur Stephan , Vladimir Nekorkin

The phase-resetting curve (PRC) describes the response of a neural oscillator to small perturbations in membrane potential. Its usefulness for predicting the dynamics of weakly coupled deterministic networks has been well characterized.…

动力系统 · 数学 2015-05-13 Aushra Abouzeid , Bard Ermentrout

The phase sensitivity curve or phase response curve (PRC) quantifies the oscillator's reaction to stimulation at a specific phase and is a primary characteristic of a self-sustained oscillatory unit. Knowledge of this curve yields a phase…

适应与自组织系统 · 物理学 2022-12-08 Rok Cestnik , Erik T. K. Mau , Michael Rosenblum

The Phase Response Curve (PRC) is a tool used in neuroscience that measures the phase shift experienced by an oscillator due to a perturbation applied at different phases of the limit cycle. In this paper we present a new approach to PRCs…

动力系统 · 数学 2019-07-24 Alberto Pérez-Cervera , Tere M. Seara , Gemma Huguet

Brain rhythms emerge as a result of synchronization among interconnected spiking neurons. Key properties of such rhythms can be gleaned from the phase-resetting curve (PRC). Inferring the macroscopic PRC and developing a systematic phase…

神经元与认知 · 定量生物学 2022-10-12 Gregory Dumont , Alberto Pérez-Cervera , Boris Gutkin

The describing function (DF) and phase response curve (PRC) are classical tools for the analysis of feedback oscillations and rhythmic behaviors, widely used across control engineering, biology, and neuroscience. These tools are known to…

系统与控制 · 电气工程与系统科学 2025-11-27 Robin Wroblowski , Rodolphe Sepulchre

We demonstrate that the phase response curve (PRC) can be reconstructed using a weighted spike-triggered average of an injected fluctuating input. The key idea is to choose the weight to be proportional to the magnitude of the fluctuation…

适应与自组织系统 · 物理学 2009-05-18 Kaiichiro Ota , Masaki Nomura , Toshio Aoyagi

We investigate the phase response properties of the Hindmarsh-Rose model of neuronal bursting using burst phase response curves (BPRCs) computed with an infinitesimal perturbation approximation and by direct simulation of synaptic input.…

动力系统 · 数学 2009-10-13 William Erik Sherwood , John Guckenheimer

Neural firing is often subject to negative feedback by adaptation currents. These currents can induce strong correlations among the time intervals between spikes. Here we study analytically the interval correlations of a broad class of…

神经元与认知 · 定量生物学 2017-04-27 Tilo Schwalger , Benjamin Lindner

The "Phase Response Curve" (PRC) is a common tool used to analyze phase resetting in the natural sciences. We make the observation that the PRC with respect to a coordinate $y\in\mathbb{R}$ actually depends on the full choice of coordinates…

定量方法 · 定量生物学 2021-11-15 Simon Wilshin , Matthew D. Kvalheim , Shai Revzen

We investigate here various properties of the responses of excitable systems subject to periodic forcing and noise. While the properties of intrinsic oscillators, subject to added periodic signals, are well understood, much less is known…

神经元与认知 · 定量生物学 2025-10-22 Jonathan E. Rubin , Justyna Signerska-Rynkowska , Jonathan Touboul

Perturbation theory is an important tool in the analysis of oscillators and their response to external stimuli. It is predicated on the assumption that the perturbations in question are "sufficiently weak", an assumption that is not always…

神经元与认知 · 定量生物学 2012-01-19 Kevin K. Lin , Kyle C. A. Wedgwood , Stephen Coombes , Lai-Sang Young

A single neuron is known to generate almost identical spike trains when the same fluctuating input is repeatedly applied. Here, we study the reliability of spike firing in a pulse-coupled network of oscillator neurons receiving fluctuating…

适应与自组织系统 · 物理学 2015-05-13 Jun-nosuke Teramae , Tomoki Fukai

We examine the effect of the phase-resetting curve (PRC) on the transfer of correlated input signals into correlated output spikes in a class of neural models receiving noisy, super-threshold stimulation. We use linear response theory to…

神经元与认知 · 定量生物学 2015-05-13 Andrea K. Barreiro , Eric Shea-Brown , Evan L. Thilo

Cortical slow oscillations occur in the mammalian brain during deep sleep and have been shown to contribute to memory consolidation, an effect that can be enhanced by electrical stimulation. As the precise underlying working mechanisms are…

神经元与认知 · 定量生物学 2013-12-31 Arne Weigenand , Thomas Martinetz , Jens Christian Claussen

Anticipated synchronization (AS) is a counter intuitive behavior that has been observed in several systems. When AS establishes in a sender-receiver configuration, the latter can predict the future dynamics of the former for certain…

神经元与认知 · 定量生物学 2017-05-31 Fernanda S. Matias , Pedro V. Carelli , Claudio R. Mirasso , Mauro Copelli
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