定量生物学
The energy dissipated by a living organism is commonly identified with heat generation. However, as cells exchange metabolites with their environment they also dissipate energy in the form of chemical entropy. How dissipation is distributed…
Genetic nurture effects and assortative mating (AM) occur across many human behaviors and can bias estimates from traditional genetic models. These influences are typically studied univariately, within the same trait. However, estimation of…
During the COVID-19 pandemic, estimating the total deaths averted by vaccination has been of great public health interest. Instead of estimating total deaths averted by vaccination among both vaccinated and unvaccinated individuals, some…
Active movement is essential for the survival of microorganisms like bacteria, algae and unicellular parasites. In three dimensions, both swimming and gliding microorganisms often exhibit helical trajectories. One such case are malaria…
This review examines the emerging role of mechanistic mathematical models based on continuum mechanics to address current challenges in glaucoma research. At present, the advent of Artificial Intelligence and data-based models have resulted…
Microbial ecosystems exhibit a surprising amount of functionally relevant diversity at all levels of taxonomic resolution, presenting a significant challenge for most modeling frameworks. A long-standing hope of theoretical ecology is that…
Additional food sources for an introduced predator are known to increase its efficiency on a target pest. In this context, inhibiting factors such as interference, predator competition, and the introduction of temporally dependent quantity…
From the formation of ice in small clusters of water molecules to the mass raids of army ant colonies, the emergent behavior of collectives depends critically on their size. At the same time, common wisdom holds that such behaviors are…
Aims. Resistance to targeted therapies remains a major challenge in EGFR-mutant non-small cell lung cancer (NSCLC). Here, we describe a novel metabolic adaptation in osimertinib-resistant cells characterized by elevated acetate levels and…
Phylogenetic trees represent certain species and their likely ancestors. In such a tree, present-day species are leaves and an edge from u to v indicates that u is an ancestor of v. Weights on these edges indicate the phylogenetic distance.…
Episodes of low dissolved oxygen concentration--hypoxia--threaten the functioning of and the services provided by aquatic ecosystems, particularly those of urban rivers. Here, we disentangle oxygen-related processes in the highly modified…
Progress of the COVID-19 pandemic was quantified, in the first instance, using the daily number of positive cases recorded by the national public health authorities. Averaged over a seven-day window, the daily incidence of COVID-19 in…
The specific region of an antibody responsible for binding to an antigen, known as the paratope, is essential for immune recognition. Accurate identification of this small yet critical region can accelerate the development of therapeutic…
Photoplethysmography (PPG) is a common tool for monitoring cardiopulmonary health. Relying on absorption or reflectance of light by hemoglobin in the blood, the measured PPG waveform can be analyzed per heart beat using physiological…
We analyze functional magnetic resonance imaging (fMRI) data from the Human Connectome Project (HCP) to match brain activities during a range of cognitive tasks. Our findings demonstrate that even basic linear machine learning models can…
Medical imaging has revolutionized diagnosis, yet unnecessary procedures are rising, exposing patients to radiation and stress, limiting equitable access, and straining healthcare systems. The American College of Radiology Appropriateness…
Arterial aneurysm (Fig.1) is a bulb-shape local expansion of human arteries, the rupture of which is a leading cause of morbidity and mortality in US. Therefore, the prediction of arterial aneurysm rupture is of great significance for…
Viral infections trigger complex immune responses with heterogeneous outcomes shaped by nonlinear feedbacks. An ordinary differential equation model is developed to investigate immune response dynamics during viral infection, incorporating…
High-resolution imaging provides dense trajectories of migrating cells, flocking animals, and synthetic active particles, from which interaction laws can be determined with a wide variety of methods. Yet, distinguishing whether front-back…
Although maturation delays are frequently included in population models, researchers rarely account for mortality between birth and maturity. Previous discrete population models have included mortality of immature individuals during the…