定量生物学
Emerging in December 2019, the COVID-19 pandemic caused widespread health, economic, and social disruptions. Rapid global transmission overwhelmed healthcare systems, resulting in high infection rates, hospitalisations, and fatalities. To…
Cells integrate signals and make decisions about their future state in short amounts of time. A lot of theoretical effort has gone into asking how to best design gene regulatory circuits that fulfill a given function, yet little is known…
The design of artificial neural networks (ANNs) is inspired by the structure of the human brain, and in turn, ANNs offer a potential means to interpret and understand brain signals. Existing methods primarily align brain signals with…
Protein-ligand binding is the process by which a small molecule (drug or inhibitor) attaches to a target protein. Binding affinity, which characterizes the strength of biomolecular interactions, is essential for tackling diverse challenges…
We investigate solutions to the TAP equation, a phenomenological implementation of the Theory of the Adjacent Possible. Several implementations of TAP are studied, with potential applications in a range of topics including economics, social…
It has long been suggested that neck muscle strength and anticipatory cocontraction can decrease head motions during head impacts. Here, we quantify the relative angular impulse contributions of neck soft tissue to head stabilization using…
Graphical domination was first introduced in [1] in the context of combinatorial threshold-linear networks (CTLNs). There it was shown that when a domination relationship exists between a pair of vertices in a graph, certain fixed points in…
Colorectal cancer (CRC) is highly heterogeneous, with five-year survival rates dropping from $\sim$90% in localized disease to $\sim$15% with distant metastases. Disease progression is shaped not only by tumor-intrinsic alterations but also…
The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…
Correlated motions of proteins underpin many physiological mechanisms, such as substrate binding, signal transduction, enzymatic activity and allostery. These motions arise from low frequency collective movements of biomolecules and have…
Climate change and fisheries jointly shape the resilience of the Barents Sea marine ecosystem, yet the recovery of key fish populations to climate and anthropogenic disturbances requires further investigation. This study examines how…
Due to the ever-rising global incidence rate of inflammatory bowel disease (IBD) and the lack of effective clinical treatment drugs, elucidating the detailed pathogenesis, seeking novel targets, and developing promising drugs are the top…
The spatiotemporal patterns of neural dynamics are jointly shaped by directed structural interactions and heterogeneous intrinsic features of the neural components. Despite well-developed methods for estimating directionality in network…
The relationship between Integrated Information Theory (IIT) and the Free-Energy Principle (FEP) remains unresolved, particularly with respect to how integrated information, proposed as the intrinsic substrate of consciousness, behaves…
Hidden Markov models (HMMs) have been used increasingly to understand how movement patterns of animals arise from behavioural states. An animal is assumed to transition between behavioural states through time, as described by transition…
Metagenomic data has significantly advanced microbiome research by employing ecological models, particularly in personalised medicine. The generalised Lotka-Volterra (gLV) model is commonly used to understand microbial interactions and…
Larval zebrafish hunting provides a tractable setting to study how ecological and energetic constraints shape adaptive behavior in both biological brains and artificial agents. Here we develop a minimal agent-based model, training recurrent…
Brain stimulation is a powerful tool for understanding cortical function and holds promise for therapeutic interventions in neuropsychiatric disorders. Initial visual prosthetics apply electric microstimulation to early visual cortex which…
Nanopore sequencing technologies continue to advance rapidly, offering critical benefits such as real-time analysis, the ability to sequence extremely long DNA fragments (up to millions of bases in a single read), and the option to…
This study investigates the impact of time since fire on bird community composition in Southern California chaparral ecosystems. We surveyed avian richness and abundance across 14 sites representing a 0 to 25 year post-fire chronosequence…