定量方法
Physiological tremor of the upper limb is a sensitive neuromuscular indicator that may be modulated by cognitive load and competitive stress, yet its behaviour in real esports conditions remains uncharacterised. We measured wrist…
Classifying heterogeneous omics data remains a fundamental challenge in computational biology, particularly in high-dimensional, small-sample settings where nonlinear interactions dominate and class imbalance further complicates reliable…
Despite increasing scale and resolution, many biological measurements remain destructive, revealing only spatial information rather than the dynamics it encodes. By combining flexible representations with mechanistic constraints,…
Histone H3K27M mutation status defines a clinically aggressive subgroup of pediatric diffuse midline glioma and informs prognosis and trial eligibility, but confirmation usually requires tissue sampling from eloquent midline structures. We…
Accurate interpretation of panoramic dental radiographs requires the integration of multiple reasoning capabilities: detection, spatial localization, and quantitative assessment. Despite recent advances in multimodal learning, existing…
Single-cell drug perturbation models should predict not only transcriptional response magnitude, but also whether a treatment alters the proliferative state of a cell. This is challenging because cell-cycle variation is often treated as…
Alzheimer's disease (AD) is characterized by the accumulation of Amyloid-$\beta$ ($A\beta$) plaques and hyperphosphorylated Tau proteins. However, many individuals exhibit substantial $A\beta$ and Tau pathology without developing dementia,…
Capsids are the protein shells that protect the genetic material of viruses. The precise structural description of capsids informs how viruses assemble and evolve and is key to the development of antiviral targets. Most viruses form…
This work examines perturbation generalization in spatial foundation-model embeddings derived from fluorescence microscopy images. Although these models can discriminate drug conditions accurately, it remains unclear whether the learned…
Background: Digital health technologies allow for frequent, remote gait monitoring in people with multiple sclerosis (MS). However, to differentiate daily variability from actual disease progression in longitudinal data, established minimal…
Background: Both between- and within-subject variations in circadian timing matter for health. If lifestyle changes could be used to regulate circadian timing, they would offer accessible and scalable routes to chronotherapy, but this link…
In this work, we interpret developmental growth as a metabolic energy allocation problem and link the von Bertalanffy growth model to metabolic energy investments into the growth channel. Using a framework that specifies how metabolic…
This paper proposes an unsupervised workflow to pseudo-label extracellular spikes from human brain slice MEA recordings into two putative cell types: pyramidal cells and interneurons. Here, the raw data from the data acquisition system is…
Parameter inference and state estimation in stochastic and partially observed biological systems remain major problems in mathematical biology. In this work, we introduce a two-dimensional lattice graph model for the spread of infectious…
In transcriptomics, gene-set-aware factorization methods such as the Pathway Level Information Extractor (PLIER) are most effective when trained on large, heterogeneous expression compendia. Yet, many clinically relevant cohorts cannot be…
A novel two-phase molecule inference framework, mol-infer, has recently been developed to infer chemical graphs with prescribed abstract structures and desired property values through mixed integer linear programming (MILP) under the…
Antibodies play a central role in the immune response by specifically recognizing and neutralizing antigens, and therapeutic antibodies have become major drugs for cancer and autoimmune diseases. However, their discovery still relies on…
From molecular, cellular, to ecological systems, the modeling of biological processes often stands on the assumption that fast components immediately reach the equilibrium at each moment (quasi-steady state) and only slow components govern…
Whisking is a rhythmic and adaptive behavior that rodents use to probe and interact with their environment, and the frequency of movement reflects both sensorimotor processing and internal brain states. A robust and traditional method of…
Liquid chromatography-mass spectrometry (LC-MS/MS) data analysis requires adaptable software solutions to meet diverse analytical needs. We present eMZed 3, a modern Python framework for flexible and interactive analysis of LC-MS/MS data.…