种群与进化
Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment. Despite its limited success, so far, in treating solid cancers, it is increasingly successful, demonstrating to have a broader therapeutic potential.…
Multidrug resistance consists of a series of genetic and epigenetic alternations that involve multifactorial and complex processes, which are a challenge to successful cancer treatments. Accompanied by advances in biotechnology and…
Cell competition is recognized to be instrumental to the dynamics and structure of the tumor-host interface in invasive cancers. In mild competition scenarios, the healthy tissue and cancer cells can coexist. When the competition is…
1. Abrupt environmental changes can lead to evolutionary shifts in trait evolution. Identifying these shifts is an important step in understanding the evolutionary history of phenotypes. 2. We propose an ensemble variable selection method…
This paper is concerned with the design of intermittent non-pharmaceutical strategies to mitigate the spread of the COVID-19 epidemic exploiting network epidemiological models. Specifically, by studying a variational equation for the…
In this work, we provide a general mathematical formalism to study the optimal control of an epidemic, such as the COVID-19 pandemic, via incentives to lockdown and testing. In particular, we model the interplay between the government and…
A long-standing goal of evolutionary biology is to decode how gene regulatory processes contribute to organismal diversity, both within and between species. This question has remained challenging to answer, due both to the difficulties of…
Since early 2020, the world has been dealing with a raging pandemic outbreak: COVID-19. A year later, vaccines have become accessible, but in limited quantities, so that governments needed to devise a strategy to decide which part of the…
In conservation biology, phylogenetic diversity (PD) provides a way to quantify the impact of the current rapid extinction of species on the evolutionary `Tree of Life'. This approach recognises that extinction not only removes species but…
Planktonic communities are extremely diverse and include a vast number of rare species. The dynamics of these rare species is best described by individual-based models. However, individual-based approaches to planktonic diversity face…
In the last two decades dengue cases increased significantly throughout the world. In several regions dengue re-emerged, particularly in Latin America, where dengue cases not only increased but also occurred more frequently. It is therefore…
Resource are often not uniformly distributed within a population. Spatial variations of concentration of a resource, change the fitness of competing strategies locally. The notion of fitness varying with respect to both genotype and…
We investigated daily COVID-19 cases and deaths in the 337 lower tier local authority regions in England and Wales to better understand how the disease propagated over a 15-month period. Population density scaling models revealed residual…
Ecological, environmental and geophysical time series consistently exhibit the characteristics of coloured (1/f^\b{eta}) noise. Here we briefly survey the literature on coloured noise, population persistence and related evolutionary…
The role of dispersal on the stability and synchrony of a metacommunity is a topic of considerable interest in theoretical ecology. Dispersal is known to promote both synchrony, which enhances the likelihood of extinction, and spatial…
Invariants for complicated objects such as those arising in phylogenetics, whether they are invariants as matrices, polynomials, or other mathematical structures, are important tools for distinguishing and working with such objects. In this…
Mathematical models have come to play a key role in global pandemic preparedness and outbreak response: helping to plan for disease burden, hospital capacity, and inform non-pharmaceutical interventions. Such models have played a pivotal…
Correlation between weather and the transmission of SARS-CoV-2 may suggest its seasonality. Cointegration analysis can avoid spurious correlation among time series data. We examined the cointegration of virus transmission with daily…
Several important aspects related to SARS-CoV-2 transmission are not well known due to a lack of appropriate data. However, mathematical and computational tools can be used to extract part of this information from the available data, like…
Successful predictive modeling of epidemics requires an understanding of the implicit feedback control strategies which are implemented by populations to modulate the spread of contagion. While this task of capturing endogenous behavior can…