医学物理
Whole-brain proton magnetic resonance spectroscopic imaging (1H-MRSI) is a non-invasive technique for assessing neurochemical distribution in the brain, offering valuable insights into brain functions and neural diseases. It greatly…
ECG-gated cine imaging in breath-hold enables high-quality diagnostics in most patients, arrhythmia and inability to hold breath, however, can severely corrupt outcomes. Real-time cardiac MRI in free-breathing leverages robust and faster…
Proton therapy offers significant advantages due to its unique physical and biological properties, particularly the Bragg peak, enabling precise dose delivery to tumors while sparing healthy tissues. However, the clinical implementation is…
In photoacoustic computed tomography (PACT) the accurate estimation of the initial pressure (IP) distribution generally requires knowledge of the object's heterogeneous speed-of-sound (SOS) distribution. Although hybrid imagers that combine…
Background: X-nuclei imaging (e.g. 31P MRI) suffers low SNR due to lower gyromagnetic ratios and tissue concentrations than 1H MRI. Enhancing SNR requires high fields, advanced coils, optimized sequences, and sophisticated reconstruction…
Successful integration of point-of-care testing (POCT) into clinical settings requires improved assay sensitivity and precision to match laboratory standards. Here, we show how innovations in amplified biosensing, imaging, and data…
Radiopharmaceutical therapies (RPTs) present a major opportunity to improve cancer therapy. Although many current RPTs use the same injected activity for all patients, there is interest in using absorbed dose measurements to enable…
In chronic liver disease, liver fibrosis develops as excessive deposition of extracellular matrix macromolecules, predominantly collagens, progressively form fibrous scars that disrupt the hepatic architecture, and fibrosis, iron, and fat…
Long lasting efforts have been made to reduce radiation dose and thus the potential radiation risk to the patient for computed tomography acquisitions without severe deterioration of image quality. To this end, numerous reconstruction and…
Electrical waves in the heart form rotating spiral or scroll waves during life-threatening arrhythmias such as atrial or ventricular fibrillation. The wave dynamics are typically modeled using coupled partial differential equations, which…
Baroreflex is critical to maintain the blood pressure homeostasis, and the quantification of the baroreflex regulation function (BRF) can provide guidance for disease diagnosis, treatment and healthcare. Current quantification of the BRF…
Using service handguns to test bullets in deer is problematic because of velocity loss with range and accuracy giving sub-optimal shot placement. An alternate method is presented using a scoped muzzleloader shooting saboted handgun bullets…
Understanding the dynamic relationship between RR and QT intervals is crucial for interpreting electrocardiograms (ECGs) and managing cardiac conditions. We investigated cross-correlation between RR and QT intervals in long-term ECG…
Inhomogeneity of the transmitted radiofrequency field B1+ is a major factor hindering the image quality in Magnetic Resonance Imaging (MRI) at high field strengths. Here, a novel approach is presented, to locally modulate the B1+ utilizing…
Objectives: To identify a head acceleration event (HAE) severity measure associated with HIA1 removals in elite level rugby union. Methods: HAEs were recorded from 215 men and 325 women with 30 and 28 HIA1 removals from men and women,…
Humans rely on ankle torque to maintain standing balance, particularly in the presence of small to moderate perturbations. Reductions in maximum torque (MT) production and maximum rate of torque development (MRTD) occur at the ankle with…
In this paper, we present a GPU-accelerated prototype implementation of a portable ultrasound imaging pipeline on an Nvidia CLARA AGX development kit. The raw data is acquired with nonsteered plane wave transmit using a programmable…
MRI-guidance techniques that dynamically adapt radiation beams to follow tumor motion in real-time will lead to more accurate cancer treatments and reduced collateral healthy tissue damage. The gold-standard for reconstruction of…
Background: Radiotherapy treatment planning involves solving large-scale optimization problems that are often approximated and solved sub-optimally due to time constraints. Central to these problems is the dose influence matrix which…
Purpose: Field monitoring using field probes allows for accurate measurement of magnetic field perturbations, such as from eddy currents, during MRI scanning. However, errors may result when the spatial variation of the fields is not…