医学物理
Purpose: Low-field MRI has been assumed to be implant-friendly based on limited studies. However, RF-induced heating due to an implant is a complex resonance phenomenon, highly dependent on the implant's configurations and the applied RF…
Background: Recently, the popularity of dual-layer flat-panel detector (DL-FPD) based dual-energy cone-beam CT (DE-CBCT) imaging has been increasing. However, the image quality of DE-CBCT remains constrained by the Compton scattered X-ray…
Fluid-structure interaction (FSI) modeling, a technique widely used to enhance imaging modalities for adult and pediatric heart diseases, has been underutilized in the context of fetal circulation because of limited data on flow conditions…
Cardiovascular diseases are best diagnosed using multiple modalities that assess both the heart's electrical and mechanical functions. While effective, imaging techniques like echocardiography and nuclear imaging are costly and not widely…
Objective: In cochlear implant users with residual acoustic hearing, compound action potentials (CAPs) can be evoked by acoustic (aCAP) or electric (eCAP) stimulation and recorded through the electrodes of the implant. We propose a novel…
Eye lens dosimetry has been an important field of research in the last decade. Dose measurements with a prototype of an active personal eye lens dosemeter based on the Dosepix detector are presented. The personal dose equivalent at $3\,$mm…
Objective: The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fast and large-scale simulations due to high computational…
Convolutional neural networks (CNNs) have recently achieved remarkable performance in positron emission tomography (PET) image reconstruction. In particular, CNN-based direct PET image reconstruction, which directly generates the…
Neuro-oncological surgery is the primary brain cancer treatment, yet it faces challenges with gliomas due to their invasiveness and the need to preserve neurological function. Hence, radical resection is often unfeasible, highlighting the…
Hybrid spectral CT integrates energy integrating detectors (EID) and photon counting detectors (PCD) into a single system, combining the large field-of-view advantage of EID with the high energy and spatial resolution of PCD. This…
A parallel 3-D Frequency Dependent Finite Difference Time Domain (FD-FDTD) method was implemented based on the Single Program Multiple Data (SPMD) technique to analyze the feasibility of microwave diagnosis for the human knees. The parallel…
Multiple scattering of waves presents challenges for imaging complex media but offers potential for their characterization. Its onset is actually governed by the scattering mean free path $\ell_s$ that provides crucial information on the…
The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non-invasive characterization of tissue, ex vivo dMRI is increasingly used to probe tissue microstructure and brain connectivity. Ex vivo dMRI has…
Fluorescence imaging allows for non-invasively visualizing and measuring key physiological parameters like pH and dissolved oxygen. In our work, we created two ratiometric fluorescent microsensors designed for accurately tracking dissolved…
In certain brain volumetric studies, synthetic T1-weighted magnetization-prepared rapid gradient-echo (MP-RAGE) contrast, derived from quantitative T1 MRI (T1-qMRI), proves highly valuable due to its clear white/gray matter boundaries for…
Significance: Pulsatile blood Oxygen Saturation (SpO2 ) via pulse oximetry is a valuable clinical metric for assessing oxygen delivery. Individual anatomical features, including skin tone, may affect current optical pulse oximetry methods.…
Background/Objectives: Cataract surgery, a very common and critical procedure for restoring vision, has outcomes that can vary based on patient demographics. This study aimed to elucidate the effects of age and sex on the risk factors,…
Purpose: To develop an MRI technique for free-breathing 3D whole-liver quantification of water T1, water T2, proton density fat fraction (PDFF), R2*. Methods: An Eight-echo spoiled gradient echo pulse sequence with spiral readout was…
Super-resolution ultrasound (SRUS) visualises microvasculature beyond the ultrasound diffraction limit (wavelength($\lambda$)/2) by localising and tracking spatially isolated microbubble contrast agents. SRUS phantoms typically consist of…
Thick honeycomb-like electrospun scaffold with nanoparticles of hydroxyapatite (nHA) recently demonstrated its potential to promote proliferation and differentiation of a murine embryonic cell line (C3H10T1/2) to osteoblasts. In order to…