医学物理
Objective: To propose a mathematical model for applying Ionization Detail (ID), the detailed spatial distribution of ionization along a particle track, to proton and ion beam radiotherapy treatment planning (RTP). Approach: Our model…
Inhalers spray over 100 million drug particles into the mouth, where a significant portion of the drug may deposit. Understanding how the complex interplay between particle and solid phases influence deposition is crucial for optimising…
For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for…
Neural health refers to the condition and functionality of the auditory nerve fibers (ANFs),which are crucial for transmitting sound signals from the cochlea to the brain.However, neural health cannot be directly measured due to current…
Purpose: Demonstrate quantitative characterization of 3D patient-specific absorbed dose distributions using Haralick texture analysis and interpret measures in terms of underlying physics and radiation dosimetry. Methods: Retrospective…
Wearable head sensor systems use different kinematic signal processing approaches which limits field-based inter-study comparisons, especially when artefacts are present in the signal. The aim of this study is to assess the frequency…
Radiotherapy with heavy ions, in particular, 12C beams, is one of the most advanced forms of cancer treatment. Sharp dose gradients and high biological effectiveness in the target region make them an ideal tool to treat deep-seated and…
Background: Targeted radiotherapies with low-energy ions show interesting possibilities for the selective irradiation of tumor cells, a strategy particularly appropriate for the treatment of disseminated cancer. Two promising examples are…
Arrays of minibeams of protons and $^{12}$C in tissue-like media were modeled with Geant4 toolkit. A set of beam energies was used in simulations to provide a Spead-out Bragg peak (SOBP) extended by 6 cm in depth for protons as well as for…
The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the clinical translation of these benefits necessitates efficient…
The recent development of Physics-Augmented Neural Networks (PANN) opens new opportunities for modeling material behaviors. These approaches have demonstrated their efficiency when trained on synthetic cases. This study aims to demonstrate…
Purpose: Auger emitters exhibit interesting features due to their emission of a cascade of short-range Auger electrons. Maximum DNA breakage efficacy is achieved when decays occur near DNA. Studies of double-strand breaks (DSBs) yields in…
We have determined the depth-dose curve, the penetration range, and the water equivalent ratio (WER), for proton beams of clinical energies in cortical bone, by means of a detailed and accurate simulation that combines molecular dynamics…
The spatial sensitivity of an ultrasound transducer, which strongly influences its suitability for different applications, depends on the shape of the transducer surface. Accurate simulation of these spatial effects is important for…
This study incorporates electromagnetic simulations to assess the performance of multi-turn solenoid coils for ultra-low field MR imaging with various conductor materials (superconducting material, low-temperature copper, and…
In magnetic resonance imaging (MRI), the spectrometer is a fundamental component of MRI systems, responsible for the transmission of radiofrequency (RF) pulses that excite hydrogen nuclei and the subsequent acquisition of MR signals for…
Systemic amyloidosis is a group of diseases characterized by the deposition of misfolded proteins in various organs and tissues, leading to progressive organ dysfunction and failure. Congo red stain is the gold standard chemical stain for…
Attenuation compensation (AC), while being beneficial for visual-interpretation tasks in myocardial perfusion imaging (MPI) by SPECT, typically requires the availability of a separate X-ray CT component, leading to additional radiation…
Purpose: To develop and compare normal tissue complication probability (NTCP) models for recurrent brain metastases (BMs) treated with repeat single-fraction stereotactic radiosurgery (SRS), considering time-dependent discounted prior dose.…
Purpose: Introducing "compensated variable-prephasing" (CVP), a phantom-based method for gradient waveform measurements. The technique is based on the "variable-prephasing" (VP) method, but takes into account the effects of all gradients…