医学物理
Histological visualizations are critical to clinical disease management and are fundamental to biological understanding. However, current approaches that rely on bright-field microscopy require extensive tissue preparation prior to imaging.…
This paper surveys the data-driven dose prediction approaches introduced for knowledge-based planning (KBP) in the last decade. These methods were classified into two major categories according to their methods and techniques of utilizing…
Postulating that increasing linear energy transfer (LET) causes non-random clustering of lethal lesions to deviate from the Poisson distribution, we employ a non-Poisson approach as a more flexible alternative that accounts for…
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to study microvascular structure and tissue perfusion. In DCE-MRI a bolus of gadolinium based contrast agent is injected into the blood stream and spatiotemporal changes…
Pancreas stereotactic body radiotherapy treatment planning requires planners to make sequential, time consuming interactions with the treatment planning system (TPS) to reach the optimal dose distribution. We seek to develop a reinforcement…
Muscle contraction is often detected via EMG in prosthetics. However, signal disturbances due to electrode motions can lead to misinterpretations. Therefore, alternative measurement approaches are desired to increase the reliability of the…
The impact of the Corona, dielectric barrier discharge and low pressure radiofrequency air plasmas on the wettability of the medical grade polyvinylchloride was investigated. Corona plasma treatment exerted the most pronounced increase in…
Due to the complexity and cumbersomeness of Gamma Knife (GK) manual forward planning, the quality of the resulting treatment plans heavily depends on the planners skill, experience and the amount of effort devoted to plan development.…
With many variables to adjust, conventional manual forward planning for Gamma Knife (GK) radiosurgery is very complicated and cumbersome. The resulting plan quality heavily depends on planners skills, experiences and devoted efforts, and…
We propose a novel T2 relaxation data analysis method which we have named spectrum analysis for multiple exponentials via experimental condition oriented simulation (SAME-ECOS). SAME-ECOS, which was developed based on a combination of…
Elastography provides significant information on staging of fibrosis in patients with liver disease and may be of some value in assessing steatosis. However, there remain questions as to the role of steatosis and fibrosis as cofactors…
Background: Approximately forty percent of all dopaminergic neurons in SNpc are located in five dense neuronal clusters, named nigrosomes. T2- or T2*-weighted images are used to delineate the largest nigrosome, named nigrosome-1. In these…
Detection of Barrett's esophagus (BE) at points of care outside the endoscopy suite may improve screening access and reduce esophageal adenocarcinoma mortality. Tethered capsule optical coherence tomography (OCT) can volumetrically image…
Purpose: To introduce, develop, and evaluate a novel denoising technique for diffusion MRI that leverages non-linear redundancy in the data to boost the SNR while preserving signal information. Methods: We exploit non-linear redundancy of…
Patlak model is widely used in 18F-FDG dynamic positron emission tomography (PET) imaging, where the estimated parametric images reveal important biochemical and physiology information. Because of better noise modeling and more information…
Objective: Accurate estimation of SAR is critical to safeguarding vulnerable patients who require an MRI procedure. The increased static field strength and RF duty cycle capabilities in modern MRI scanners mean that systems can easily…
Motion management is a critical component of image guidance radiotherapy for lung cancer. We previously proposed a scheme using kV scattered x-ray photons for marker-less real-time image guidance in lung cancer radiotherapy. This study…
After 100 years of theoretical treatment of speckle patterns from coherent illumination, there remain some open questions about the nature of ultrasound speckle from soft vascularized tissues. A recent hypothesis is that the fractal…
Theranostics, the combination of diagnosis and therapy, has long held promise as a means to achieving personalised precision cancer treatments. However, despite its potential, theranostics has yet to realise significant clinical…
{\bf Introduction}: To revisit the formulation of the mean chord length in microdosimetry and replace it by the particle mean free path appropriate for modelings in radio-biology. {\bf Methods}: We perform a collision-by-collision following…