医学物理

Purpose: Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased interest in public…

Novel approaches for predicting the outcomes of blood-brain barrier (BBB) opening with focused ultrasound (FUS) and microbubbles are highly desired. This study aims to explore machine learning-based methods for reliably predicting the…

Non-invasive imaging plays a crucial role in diagnosing and studying eye diseases. However, existing photoacoustic ophthalmoscopy (PAOM) techniques in mice have limitations due to handling restrictions, suboptimal optical properties,…

Monte Carlo (MC) techniques are currently deemed the gold standard for internal dosimetry, since the simulations can perform full radiation transport and reach a precision level not attainable by analytical methods. In this study, a custom…

The goal of this work is to present results of field output factors (OF) using an IBA CC003 (Razor NanoChamber) and compared these results with PTW 60019 (MicroDiamond) and IBA Razor Diode. The experimental results for IBA CC003 were also…

Alzheimer's is a neurodegenerative disease that is the most common form of dementia, but there is still no definitive cure for this disease. The noninvasive X-ray Phase Contrast Tomography (XPCT) imaging technique was used to study brain…

Pancreatic cancer with more than 60,000 new cases each year has less than 10 percent 5-year overall survival. Radiation therapy (RT) is an effective treatment for Locally advanced pancreatic cancer (LAPC). The current clinical RT workflow…

This work proposes a method to accelerate the acquisition of high-quality edited magnetic resonance spectroscopy (MRS) scans using machine learning models taking the sample covariance matrix as input. The method is invariant to the number…

Considering liver as the reference, that both fast diffusion (PF) and slow diffusion (Dslow) of the spleen are much underestimated is likely due to the MRI properties of the spleen such as the much longer T2 relaxation time. It is possible…

Purpose: In multi-spectral imaging (MSI), several fast spin echo volumes with discrete Larmor frequency offsets are acquired in an interleaved fashion with multiple concatenations. Here, a variable resolution (VR) method to nearly halve…

In magnetoencephalography, linear minimum norm inverse methods are commonly employed when a solution with minimal a priori assumptions is desirable. These methods typically produce spatially extended inverse solutions, even when the…

Objective: Use of a vascular punch to produce circular heel and toe arteriotomies for femoral endarterectomy with patch angioplasty is a novel technique. This study investigated the plausibility of this approach and the mechanical…

A Geant4 based simulation platform of the Holland Proton Therapy Centre (HollandPTC, Netherlands) R&D beamline (G4HPTC-R&D) was developed to enable the planning, optimisation and advanced dosimetry for radiobiological studies. It…

Purpose: To develop a DL-based PBSPT dose prediction workflow with high accuracy and balanced complexity to support on-line adaptive proton therapy clinical decision and subsequent replanning. Methods: PBSPT plans of 103 prostate cancer…

Plasma medicine is an emerging and innovative interdisciplinary research field combining biology, chemistry, physics, engineering, and medicine. However, the safe clinical application of cold atmospheric plasma (CAP) technology is still a…

Metal artifacts caused by the presence of metallic implants tremendously degrade the reconstructed computed tomography (CT) image quality, affecting clinical diagnosis or reducing the accuracy of organ delineation and dose calculation in…

Diffusion MRI (dMRI) is a valuable imaging technique to study the brain in vivo. However, the resolution of dMRI is limited by the low signal-to-noise ratio (SNR) of this technique. Various acquisition strategies have been developed to…

SPECT provides a mechanism to perform absorbed-dose quantification tasks for $\alpha$-particle radiopharmaceutical therapies ($\alpha$-RPTs). However, quantitative SPECT for $\alpha$-RPT is challenging due to the low number of detected…

Introduction: Wrist instability remains a common health concern. The potential of dynamic Magnetic Resonance Imaging (MRI) in assessing carpal dynamics associated with this condition is a field of ongoing research. This study contributes to…

Supervised deep learning methods typically rely on large datasets for training. Ethical and practical considerations usually make it difficult to access large amounts of healthcare data, such as medical images, with known task-specific…