中文

Fast DNA translocation through a solid-state nanopore

生物大分子 2015-06-26 v1 软凝聚态物质 生物物理

摘要

We report translocation experiments on double-strand DNA through a silicon oxide nanopore. Samples containing DNA fragments with seven different lengths between 2000 to 96000 basepairs have been electrophoretically driven through a 10 nm pore. We find a power-law scaling of the translocation time versus length, with an exponent of 1.26 ±\pm 0.07. This behavior is qualitatively different from the linear behavior observed in similar experiments performed with protein pores. We address the observed nonlinear scaling in a theoretical model that describes experiments where hydrodynamic drag on the section of the polymer outside the pore is the dominant force counteracting the driving. We show that this is the case in our experiments and derive a power-law scaling with an exponent of 1.18, in excellent agreement with our data.

关键词

引用

@article{arxiv.q-bio/0404041,
  title  = {Fast DNA translocation through a solid-state nanopore},
  author = {Arnold J. Storm and Cornelis Storm and Jianghua Chen and Henny Zandbergen and Jean-Francois Joanny and Cees Dekker},
  journal= {arXiv preprint arXiv:q-bio/0404041},
  year   = {2015}
}

备注

5 pages, 2 figures. Submitted to PRL