相关论文: Resultants in Genetic Linkage Analysis
This paper is expository and is accessible to students. We define simple invariants of knots or links (linking number, Arf-Casson invariants and Alexander-Conway polynomials) motivated by interesting results whose statements are accessible…
The conormal lift of a link $K$ in $\R^3$ is a Legendrian submanifold $\Lambda_K$ in the unit cotangent bundle $U^* \R^3$ of $\R^3$ with contact structure equal to the kernel of the Liouville form. Knot contact homology, a topological link…
In this paper we announce the existence of a family of new $2$-variable polynomial invariants for oriented classical links defined via a Markov trace on the Yokonuma-Hecke algebra of type $A$. Yokonuma-Hecke algebras are generalizations of…
Estimating a covariance matrix is central to high-dimensional data analysis. Empirical analyses of high-dimensional biomedical data, including genomics, proteomics, microbiome, and neuroimaging, among others, consistently reveal strong…
While covariance matrices have been widely studied in many scientific fields, relatively limited progress has been made on estimating conditional covariances that permits a large covariance matrix to vary with high-dimensional subject-level…
Let $\text{GL}(n) = \text{GL}(n, {\mathbb C})$ denote the complex general linear group and let $G \subset \text{GL}(n)$ be one of the classical complex subgroups $\text{O}(n)$, $\text{SO}(n)$, and $\text{Sp}(2k)$ (in the case $n = 2k$). We…
Studies of the genetic loci that contribute to variation in gene expression frequently identify loci with broad effect on gene expression: expression quantitative trait locus (eQTL) hotspots. We describe a set of exploratory graphical…
This paper describes a method for the automatic evaluation of the Links-Gould two-variable polynomial link invariant (LG) for any link, given only a braid presentation. This method is currently feasible for the evaluation of LG for links…
2 Diabetes is a leading worldwide public health concern, and its increasing prevalence has significant health and economic importance in all nations. The condition is a multifactorial disorder with a complex aetiology. The genetic…
Diagnosing an inherited disease often requires identifying the pattern of inheritance in a patient's family. We represent family trees with genetic patterns of inheritance using hypergraphs and latent state space models to provide…
Over a field K of characteristic 0, we study the algebra of invariants of the general linear group GL(4,K) acting by simultaneous conjugation on two matrices of order 4. It coincides with the trace algebra generated by all traces of…
Converging evidence suggests that common complex diseases with the same or similar clinical manifestations could have different underlying genetic etiologies. While current research interests have shifted toward uncovering rare variants and…
In this note we prove some structural properties of all the A1-homotopy invariants of corner skew Laurent polynomial algebras. As an application, we compute de mod-l algebraic K-theory of Leavitt path algebras using solely the…
With the advance of high-throughput genotyping and sequencing technologies, it becomes feasible to comprehensive evaluate the role of massive genetic predictors in disease prediction. There exists, therefore, a critical need for developing…
As a generalization of the linking number, we construct a set of invariant numbers for two-component handlebody-links. These numbers are elementary divisors associated with the natural homomorphism from the first homology group of a…
Given a normal surface singularity (X,0), its link, M is a closed differentiable three dimensional manifold which carries much analytic information. It is an interesting question to ask whether, under suitable analytic and topological…
We determine fundamental systems of invariants for complex solvable rigid Lie algebras having nonsplit nilradicals of characteristic sequence $(3,1,..,1)$, these algebras being the natural followers of solvable algebras having Heisenberg…
In this manuscript, we study the statistical properties of convex clustering. We establish that convex clustering is closely related to single linkage hierarchical clustering and $k$-means clustering. In addition, we derive the range of…
In Genome-Wide Association Studies (GWAS), heritability is defined as the fraction of variance of an outcome explained by a large number of genetic predictors in a high-dimensional polygenic linear model. This work studies the asymptotic…
Traditional survival analysis techniques focus on the occurrence of failures over the time. During analysis of such events, ignoring the related unobserved covariates or heterogeneity involved in data sample may leads us to adverse…