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Standard cardiovascular risk calculators, including the Framingham Risk Score and the ACC/AHA Pooled Cohort Equations, estimate the conditional probability P(CHD | SysBP = s) rather than the interventional quantity P(CHD | do(SysBP = s)).…

应用统计 · 统计学 2026-05-08 Suchibrata Patra

Atherosclerotic lesions within carotid and cerebral vessels are likely to influence hemodynamics and manifest into vascular pathologies, including Alzheimers Disease and ischemic stroke. Hemodynamics are influenced by changes in luminal…

组织与器官 · 定量生物学 2023-03-24 Jennifer Buoncore , Alexis Sobecki , Brian Lee Beatty

This paper investigates the existence of periodic solutions in blood flow propagating through vessels with free boundary conditions via the bifurcation theory. It is rigorously proved that a local $C^1$-curve of small-amplitude periodic…

偏微分方程分析 · 数学 2026-02-26 Yuchao He , Yongli Song , Yonghui Xia

We propose a hemodynamic reduced-order model bridging macroscopic and meso-scopic blood flow circulation scales from arteries to capillaries. In silico tree like vascular geometries, mathematically described by graphs, are synthetically…

医学物理 · 物理学 2019-07-29 Olivier Adjoua , Stéphanie Pitre-Champagnat , Didier Lucor

Whole-body hemodynamics simulators, which model blood flow and pressure waveforms as functions of physiological parameters, are now essential tools for studying cardiovascular systems. However, solving the corresponding inverse problem of…

Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear-thinning is intimately related to the dynamics and mutual interactions of red blood cells (RBCs), the major…

In this study OpenFOAM 4.4.2 was used to investigate flow inside the coronary artery of the heart. This step is the first step of our future project, which is to include conjugate heat transfer of the heart with three main coronary…

医学物理 · 物理学 2021-07-19 Mohammadreza Nezamirad , Nasim Sabetpour , Azadeh Yazdi , Amirmasoud Hamedi

Cardio/cerebrovascular diseases (CVD) have become one of the major health issue in our societies. But recent studies show that the present pathology tests to detect CVD are ineffectual as they do not consider different stages of platelet…

Mathematical models that accurately predict the mechanical behavior of blood can contribute to the development of biomedical devices and medications which are relevant in clinical applications. The models existing in the literature are…

流体动力学 · 物理学 2018-08-27 Corina S. Drapaca , Zhifeng Zhang , Ruifan Meng

Recently, we have demonstrated a method to record the longitudinal phase-space distribution of a pulsed cryogenic buffer gas cooled beam of barium fluoride molecules. In this paper, we use this method to determine the influence of various…

Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite…

组织与器官 · 定量生物学 2015-06-15 Klas H. Pettersen , Scott M. Bugenhagen , Javaid Nauman , Daniel A. Beard , Stig W. Omholt

Airborne pathogen transmission mechanisms play a key role in the spread of infectious diseases such as COVID-19. In this work, we propose a computational fluid dynamics (CFD) approach to model and statistically characterize airborne…

流体动力学 · 物理学 2023-11-07 Fatih Gulec , Falko Dressler , Andrew W. Eckford

Purpose- Coarctation of the Aorta (CoA) patient-specific computational fluid dynamics (CFD) studies in resource constrained settings are limited by the available imaging modalities for geometry and velocity data acquisition. Doppler…

计算工程、金融与科学 · 计算机科学 2025-06-04 Vincent Milimo Masilokwa Punabantu , Malebogo Ngoepe , Amit Kumar Mishra , Thomas Aldersley , John Lawrenson , Liesl Zuhlke

Hypertension is a highly prevalent chronic medical condition and a strong risk factor for cardiovascular disease (CVD), as it accounts for more than $45\%$ of CVD. The relation between blood pressure (BP) and its risk factors cannot be…

应用统计 · 统计学 2023-07-25 Sanna Soomro , Keming Yu

Measurements of the current-voltage characteristics were performed on Ba(Fe$_{1-x}$Co$_x$)$_2$As$_2$ single crystals with doping level $0.044 \leq x \leq 0.1$. An unconventional increase in the flux-flow resistivity $\rho_{\rm ff}$ with…

超导电性 · 物理学 2017-05-31 Xinyi Huang , D. J. Haney , Y. P. Singh , T. Hu , H. Xiao , Hai-Hu Wen , M. Dzero , Carmen. C. Almasan

This study investigates the influence of aneurysm evolution on hemodynamic characteristics within the sac region. Using computational fluid dynamics (CFD), blood flow through the parent vessel and aneurysm sac was analyzed to assess the…

定量方法 · 定量生物学 2026-02-17 Reza Bozorgpour , Jacob R. Rammer

Serotonin (5-hydroxytryptamine) is a major neurotransmitter whose release from densely distributed serotonergic varicosities shapes plasticity and network integration throughout the brain, yet its extracellular dynamics remain poorly…

组织与器官 · 定量生物学 2026-05-21 Merlin Pelz , Skirmantas Janusonis , Gregory Handy

Zero-dimensional cardiovascular models provide a computationally efficient framework for studying global hemodynamic behavior, yet the influence of model complexity on parameter sensitivity remains insufficiently understood. This work…

医学物理 · 物理学 2026-01-05 Pranav Kumar Sasikumar

Complex fluids flow in complex ways in complex structures. Transport of water and various organic and inorganic molecules in the central nervous system are important in a wide range of biological and medical processes [C. Nicholson, and S.…

生物物理 · 物理学 2021-05-19 Yi Zhu , Shixin Xu , Robert S. Eisenberg , Huaxiong Huang

Defining vascular age in terms of physiological function has become one focal point of the extensive studies to categorize and track chronological age. Transcranial Doppler (TCD) is a method by which cerebral blood flow velocity is measured…

人工智能 · 计算机科学 2026-05-19 Anni Zhao , Alex Bateh , Tyler Baldridge , Sandra Billinger , Xiao Hu