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We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations. The model describes explicitly the directed motion of the molecular…

生物物理 · 物理学 2017-09-20 Sarah Klein , Cécile Appert-Rolland , Ludger Santen

We study time continuous branching processes with exponentially distributed lifetimes, with two types of cells that proliferate according to binary fission. A range of possible system dynamics are considered, each of which is characterized…

概率论 · 数学 2022-04-27 Nam H Nguyen , Marek Kimmel

Optical tracking in vivo experiments reveal that diffusion of particles in biological cells is strongly enhanced in the presence of ATP and the experimental data for animal cells could previously be reproduced within a phenomenological…

软凝聚态物质 · 物理学 2017-03-22 Kento Yasuda , Ryuichi Okamoto , Shigeyuki Komura , Alexander S. Mikhailov

Biological functionality of cellular aggregates is largely influenced by the activity and displacements of individual constituent cells. From a theoretical perspective this activity can be characterized by hydrodynamic transport…

软凝聚态物质 · 物理学 2025-07-31 Subhadip Chakraborti , Vasily Zaburdaev

In an inspiring recent study, Xu et al. [Nat. Phys. 19, 46 (2023)] observed for a living active biofilm under circular confinement two emergent dynamic modes of collective motion in the film. One corresponds to global rotational motion of…

软凝聚态物质 · 物理学 2025-02-11 Henning Reinken , Andreas M. Menzel

Motivated by applications in mathematical biology concerning randomly alternating motion of micro-organisms, we analyze a generalized integrated telegraph process. The random times between consecutive velocity reversals are…

概率论 · 数学 2008-03-10 Antonio Di Crescenzo , Barbara Martinucci

Tracking experiments in dense biological tissues reveal a diversity of sources f or local energy injection at the cell scale. The effect of cell motility has been largely studied, but much less is known abo ut the effect of the observed…

软凝聚态物质 · 物理学 2017-11-29 Elsen Tjhung , Ludovic Berthier

The purpose of this paper is to implement a random death process into a persistent random walk model which produces subballistic superdiffusion (L\'{e}vy walk). We develop a Markovian model of cell motility with the extra residence variable…

统计力学 · 物理学 2015-05-20 Sergei Fedotov , Abby Tan , Andrey Zubarev

Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal…

生物物理 · 物理学 2015-10-28 Naama Brenner , C. M. Newman , Dino Osmanovic , Yitzhak Rabin , Hanna Salman , D. L. Stein

The analysis of glioblastoma (GB) cell locomotion and its modeling inspired by Levy random walks is presented herein. We study such walks occurring on a two-dimensional plane where the walk is similar to the motion of a bird flying with a…

Epithelia form protective barriers in multicellular organisms. To maintain homeostasis, they must be able to regenerate and heal damaged areas. This occurs through collective cell migration, during which finger-like protrusions commonly…

Heat transfer and dissipation exists in almost any physical, chemical or biological systems. Cells, as the basic unit of life, undergo continuous heat transfer and dissipation during their metabolism. The heat transfer and dissipation…

生物物理 · 物理学 2019-01-03 Pei Song , He Gao , Miao Zhang , Fan Yang , Shan-Shan Li , Bin Kang , Jing-Juan Xu , Hong-Yuan Chen

For various species of biological cells, experimental observations indicate the existence of universal distributions of the cellular size, scaling relations between the cell-size moments and simple rules for the cell-size control. We…

软凝聚态物质 · 物理学 2017-01-12 David A. Kessler , Stanislav Burov

We propose a model for cell migration where epithelial cells are able to detect trajectories of other cells and try to follow them. As cells move along in 2D cell culture, they mark their paths by loosing tiny parts of cytoplasm. Any cell…

凝聚态物理 · 物理学 2009-11-07 Stefan Thurner , Nikolaus Wick , Rudolf Hanel , Roland Sedivy , Lukas Huber

It is experimentally known that virus exhibits stochastic motion in cytoplasm of a living cell in the free form as well as the form being contained in the endosome and the exponent of anomalous diffusion of the virus fluctuates depending on…

生物物理 · 物理学 2015-06-22 Yuichi Itto

Migration of cells can be characterized by two, prototypical types of motion: individual and collective migration. We propose a statistical-inference approach designed to detect the presence of cell-cell interactions that give rise to…

细胞行为 · 定量生物学 2020-03-13 Elena Agliari , Pablo J. Sáez , Adriano Barra , Matthieu Piel , Pablo Vargas , Michele Castellana

We introduce the notion of cell division-induced activity and show that the cell division generates extensile forces and drives dynamical patterns in cell assemblies. Extending the hydrodynamic models of lyotropic active nematics we…

软凝聚态物质 · 物理学 2015-08-07 Amin Doostmohammadi , Sumesh P. Thampi , Thuan B. Saw , Chwee T. Lim , Benoit Ladoux , Julia M. Yeomans

Mathematical models have been widely used to describe the collective movement of bacteria by chemotaxis. In particular, bacterial concentration waves traveling in a narrow channel have been experimentally observed and can be precisely…

偏微分方程分析 · 数学 2016-04-15 Casimir Emako , Charlène Gayrard , Axel Buguin , Luís Neves de Almeida , Nicolas Vauchelet

In order to study the effect of cell elastic properties on the behavior of assemblies of motile cells, this paper describes an alternative to the cell phase field (CPF) \cite{Palmieri2015} we have previously proposed. The CPF is a…

软凝聚态物质 · 物理学 2019-05-23 Yony Bresler , Benoit Palmieri , Martin Grant

Fluctuations of cell state, e.g., abundances of some proteins, have attracted much attention both theoretically and experimentally. The distribution of such state over cells, however, is not only a result of intracellular stochastic…

生物物理 · 物理学 2007-05-23 Katsuhiko Sato , Kunihiko Kaneko