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Anisotropic collective patterns occur frequently in the morphogenesis of 2D biofilms. These patterns are often attributed to growth regulation mechanisms and differentiation based on gradients of diffusing nutrients and signalling…

A powerful experimental approach for investigating computation in networks of biological neurons is the use of cultured dissociated cortical cells grown into networks on a multi-electrode array. Such preparations allow investigation of…

神经元与认知 · 定量生物学 2008-05-23 M. Stiber , F. Kawasaki , D. Xu

We first briefly recall the basic mechanisms controlling the hydrodynamic and thermo-diffusive stability of planar laminar premixed flames, and give the state of the theoretical analysis. We then describe some novel experiments to observe…

经典物理 · 物理学 2007-05-23 Geoffrey Searby

Mechanical densification of granular bodies is a process in which a loose material becomes increasingly cohesive as the applied pressure increases. A constitutive description of this process faces the formidable problem that granular and…

数学物理 · 物理学 2015-05-20 Andrea Piccolroaz , Davide Bigoni , Alessandro Gajo

Growing monolayers of rod-shaped bacteria exhibit local alignment similar to extensile active nematics. When confined in a channel or growing inward from a ring, the local nematic order of these monolayers changes to a global ordering with…

软凝聚态物质 · 物理学 2024-11-04 Blake Langeslay , Gabriel Juarez

We study the equilibrium configurations related to the growth of an elastic fibre in a confining flexible ring. This system represents a paradigm for a variety of biological, medical, and engineering problems. We consider a simplified…

软凝聚态物质 · 物理学 2022-10-17 Arsenio Cutolo , Massimiliano Fraldi , Gaetano Napoli , Giuseppe Puglisi

A key process in the life of any multicellular organism is its development from a single egg into a full grown adult. The first step in this process often consists of forming a tissue layer out of randomly placed cells on the surface of the…

We present a generic theory for the dynamics of a stiff filament under tension, in an active medium with orientational correlations, such as a microtubule in contractile actin. In sharp contrast to the case of a passive medium, we find the…

软凝聚态物质 · 物理学 2009-01-28 Norio Kikuchi , Allen Ehrlicher , Daniel Koch , Josef A. Käs , Sriram Ramaswamy , Madan Rao

Both animal and plant tissue exhibit a nonlinear rheological phenomenon known as compression stiffening, or an increase in moduli with increasing uniaxial compressive strain. Does such a phenomenon exist in single cells, which are the…

Motivated by diverse phenomena in cellular biophysics, including bacterial flagellar motion and DNA transcription and replication, we study the overdamped nonlinear dynamics of a rotationally forced filament with twist and bend elasticity.…

软凝聚态物质 · 物理学 2009-10-31 Charles W. Wolgemuth , Thomas R. Powers , Raymond E. Goldstein

This paper presents a real-time simulation involving ''protozoan-like'' cells that evolve by natural selection in a physical 2D ecosystem. Selection pressure is exerted via the requirements to collect mass and energy from the surroundings…

神经与进化计算 · 计算机科学 2023-05-23 Dylan Cope

Monte Carlo simulations are employed to investigate the surface growth generated by deposition of particles of different sizes on a substrate, in one and two dimensions. The particles have a linear form, and occupy an integer number of…

统计力学 · 物理学 2011-11-17 F. L. Forgerini , W. Figueiredo

Microbond tests composed of single fibre and matrix droplet are often used to determine the properties of fibre reinforced composites. Interfacial shear strength is quantified by the maximum pull-out force assuming a uniform stress…

材料科学 · 物理学 2009-05-29 Jan Novak , Chris J. Pearce , Peter Grassl , Liu Yang , James Thomason

We construct a homogeneous, nonlinear elastic constitutive law, that models aspects of the mechanical behavior of inhomogeneous fibrin networks. Fibers in such networks buckle when in compression. We model this as a loss of stiffness in…

生物物理 · 物理学 2015-12-18 Phoebus Rosakis , Jacob Notbohm , Guruswami Ravichandran

The model analyzes the muscle fiber as a deformable system for which experimental data are determinated with the help of the laws of Newtonian mechanic. The model predicts the four transient phases for the shortening of a muscle fiber…

组织与器官 · 定量生物学 2013-11-19 Sylvain Louvet

We consider disordered solids in which the microscopic elements can deform plastically in response to stresses on them. We show that by driving the system periodically, this plasticity can be exploited to train in desired elastic…

软凝聚态物质 · 物理学 2022-06-01 Daniel Hexner , Andrea J. Liu , Sidney R. Nagel

Everyday experience shows that cellular sheets are stiffened by the presence of a pressurized gas: from bicycle inner tubes to bubble wrap, the presence of an internal pressure increases the stiffness of otherwise floppy structures. The…

Disordered fibrous networks are ubiquitous in nature as major structural components of living cells and tissues. The mechanical stability of networks generally depends on the degree of connectivity: only when the average number of…

生物物理 · 物理学 2016-06-22 A. Sharma , A. J. Licup , R. Rens , M. Sheinman , K. A. Jansen , G. H. Koenderink , F. C. MacKintosh

A general model is formulated for elasto-plastic materials undergoing linear kinematic hardening to describe microstructure evolution associated with phase transformations. Using infinitesimal strain theory, the model is based on…

计算工程、金融与科学 · 计算机科学 2026-02-20 Sarah Dinkelacker-Steinhoff , Klaus Hackl

The self-organization of cells into complex tissues relies on a tight coordination of cell behavior. Identifying the cellular processes driving tissue growth is key to understanding the emergence of tissue forms and devising targeted…

定量方法 · 定量生物学 2024-03-27 Ruslan Mukhamadiarov , Matteo Ciarchi , Fabrizio Olmeda , Steffen Rulands