相关论文: Does Corticothalamic Feedback Control Cortical Vel…

The mammalian cortex is divided into architectonic and functionally distinct areas. There is growing experimental evidence that their emergence and development is controlled by both epigenetic and genetic factors. The latter were recently…

The information transfer in the thalamus is blocked dynamically during sleep, in conjunction with the occurence of spindle waves. As the theoretical understanding of the mechanism remains incomplete, we analyze two modeling approaches for a…

A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps reveal the brain's underlying computations. We investigate how the nematode C. elegans responds to…

The human somatosensory cortex is intimately linked to other central brain functions such as vision, audition, mechanoreception, and motor planning and control. These links are established through brain learning, and display a considerable…

The co-occurrence of action potentials of pairs of neurons within short time intervals is known since long. Such synchronous events can appear time-locked to the behavior of an animal and also theoretical considerations argue for a…

There are significant analogies between the issues related to real-time event selection in HEP, and the issues faced by the human visual system. In fact, the visual system needs to extract rapidly the most important elements of the external…

The ability of a cell to communicate with its environment is essential for key cellular functions like replication, metabolism, or cell fate decisions. The involved molecular mechanisms are highly dynamic and difficult to capture…

For decades the external globus pallidus (GPe) has been viewed as a passive way-station in the indirect pathway of the cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to…

It remains uncertain regarding the safety of driving in autonomous vehicles that, after a long, passive control and inattention to the driving situation, how the drivers will be effectively informed to take-over the control in emergency. In…

The use of cortical field potentials rather than the details of spike trains as the basis for cognitive information processing is proposed. This results in a space of cognitive elements with natural metrics. Sets of spike trains may also be…

Many studies have shown that the excitation and inhibition received by cortical neurons remain roughly balanced across many conditions. A key question for understanding the dynamical regime of cortex is the nature of this balancing.…

In this paper we develop a geometrical model of functional architecture for the processing of spatio-temporal visual stimuli. The model arises from the properties of the receptive field linear dynamics of orientation and speed-selective…

Influential models of primate visual cortex describe two functionally distinct pathways: a ventral pathway for object recognition and the dorsal pathway for spatial and action processing. However, recent human and non-human primate research…

Neurons in primary auditory cortex (AI) in the ferret (Mustela putorius) that are well described by their spectro-temporal response field (STRF), are found also to have a distinctive property that we call temporal symmetry. For temporally…

Feedback is a most important concept in control systems, its main purpose is to deal with internal and/or external uncertainties in dynamical systems, by using the on-line observed information. Thus, a fundamental problem in control theory…

A core challenge for the brain is to process information across various timescales. This could be achieved by a hierarchical organization of temporal processing through intrinsic mechanisms (e.g., recurrent coupling or adaptation), but…

Neuromodulation is central to the adaptation and robustness of animal nervous systems. This paper explores the classical paradigm of indirect adaptive control to design neuromodulatory controllers in conductance-based neuronal models. The…

The microtubule cytoskeleton is comprised of dynamic, polarized filaments that facilitate transport within the cell. Polarized microtubule arrays are key to facilitating cargo transport in long cells such as neurons. Microtubules also…

Mammalian functional architecture flexibly adapts, transitioning from integration where information is distributed across the cortex, to segregation where information is focal in densely connected communities of brain regions. This…

Neuronal growth cones are the most sensitive amongst eukaryotic cells in responding to directional chemical cues. Although a dynamic microtubule cytoskeleton has been shown to be essential for growth cone turning, the precise nature of…