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In this paper we analyze the equilibrium properties of a large class of stochastic processes describing the fundamental biological process within bacterial cells, {\em the production process of proteins}. Stochastic models classically used…

分子网络 · 定量生物学 2019-10-17 Philippe Robert

Biological evolution can be conceptualized as a search process in the space of gene sequences guided by the fitness landscape, a mapping that assigns a measure of reproductive value to each genotype. Here we discuss probabilistic models of…

种群与进化 · 定量生物学 2024-04-10 Joachim Krug , Daniel Oros

Recent research has extended methods from the fields of thermodynamics and statistical mechanics into other disciplines. Most notably, one recent work creates a unified theoretical framework to understand evolutionary biology, machine…

种群与进化 · 定量生物学 2024-05-22 Daniel Sadasivan , Cole Cantu , Cecilia Marsh , Andrew Graham

We describe a continuous-time modelling framework for biological population dynamics that accounts for demographic noise. In the spirit of the methodology used by statistical physicists, transitions between the states of the system are…

种群与进化 · 定量生物学 2018-07-19 George W. A. Constable , Alan J. McKane

Ecology and evolution are inseparable. Motivated by some recent experiments, we have developed models of evolutionary ecology from the perspective of dynamic networks. In these models, in addition to the intra-node dynamics, which…

种群与进化 · 定量生物学 2009-11-10 Debashish Chowdhury , Dietrich Stauffer

This paper introduces a mathematical framework of a stochastic process model as a generalization of diffusion stochastic processes to model latent variables in categorical responses given unobserved random effects and maximum likelihood…

统计理论 · 数学 2023-06-05 Mahdi Mollakazemiha

The recent interest in human dynamics has led researchers to investigate the stochastic processes that explain human behaviour in various contexts. Here we propose a generative model to capture the dynamics of survival analysis,…

物理与社会 · 物理学 2015-09-30 Trevor Fenner , Mark Levene , George Loizou

Single-cell gene expression measurements encode variability spanning molecular noise, cell-to-cell heterogeneity, and technical artifacts. Mechanistic stochastic models provide powerful approaches to disentangle these sources, yet inferring…

定量方法 · 定量生物学 2025-09-19 Christopher E. Miles

We present a selective review of statistical modeling of dynamic networks. We focus on models with latent variables, specifically, the latent space models and the latent class models (or stochastic blockmodels), which investigate both the…

统计方法学 · 统计学 2018-05-31 Bomin Kim , Kevin Lee , Lingzhou Xue , Xiaoyue Niu

After an introduction to the general topic of models for a given locus of a diploid population whose quadratic dynamics is determined by a fitness landscape, we consider more specifically the models that can be treated using genetic (or…

种群与进化 · 定量生物学 2016-07-08 Nicolas Grosjean , Thierry Huillet , Geneviève Rollet

We present an application of the theory of stochastic processes to model and categorize non-equilibrium physical phenomena. The concepts of uniformly continuous probability measures and modular evolution lead to a systematic hierarchical…

数学物理 · 物理学 2009-08-18 Enrique Hernandez-Lemus , Jesus K. Estrada-Gil

The neutral theory of genetic and linguistic evolution holds that the relative frequencies of variants evolve by random drift. Neutral evolution remains a plausible null model of language change. In this paper we provide evidence against…

物理与社会 · 物理学 2020-05-18 James Burridge , Tamsin Blaxter

State-space models are dynamical systems defined by a latent and an observed process. In ecology, stochastic state-space models in discrete time are most often used to describe the imperfectly observed dynamics of population sizes or animal…

统计方法学 · 统计学 2025-08-13 Frederic Barraquand , Julien Gibaud

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

神经元与认知 · 定量生物学 2026-02-10 Ahmed ElGazzar , Marcel van Gerven

Stochastic dynamic models have been extensively used for the description of processes with uncertainties arising in the operations research, behavioral sciences, and many other application areas. A large class of the problems from these…

数值分析 · 数学 2021-06-01 Thi Kim Thoa Thieu , Roderick Melnik

In the last decade, stochastic models have shown to be very useful for quantitative modelling of social processes. Here, a configurational master equation for the description of behavioral changes by pair interactions of individuals is…

统计力学 · 物理学 2009-10-31 Dirk Helbing

In the last years, tens of thousands gene expression profiles for cells of several organisms have been monitored. Gene expression is a complex transcriptional process where mRNA molecules are translated into proteins, which control most of…

生物大分子 · 定量生物学 2009-11-11 T. Ochiai , J. C. Nacher , T. Akutsu

We study how environmental stochasticity influences the long-term population size in certain one- and two-species models. The difficulty is that even when one can prove that there is persistence, it is usually impossible to say anything…

种群与进化 · 定量生物学 2025-07-15 Alexandru Hening , Siddharth Sabharwal

Stochastic storage models based on essentially non-Gaussian noise are considered. The stochastic description of physical systems based on stochastic storage models is associated with generalized Poisson (or shot) noise, in which the jump…

统计力学 · 物理学 2025-09-22 V. V. Ryazanov

In this paper, we consider a stochastic ratio-dependent predator-prey model. We firstly prove the existence, uniqueness and positivity of the solutions. Then, the boundedness of moments of population are studied. Finally, we show the…

概率论 · 数学 2015-09-01 Nguyen Thi Hoai Linh , Ta Viet Ton