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Intracellular transport is essential for maintaining proper cellular function in most eukaryotic cells, with perturbations in active transport resulting in several types of disease. Efficient delivery of critical cargos to specific…

生物物理 · 物理学 2016-08-16 David Ando , Nickolay Korabel , Kerwyn Casey Huang , Ajay Gopinathan

Connectomics and network neuroscience offer quantitative scientific frameworks for modeling and analyzing networks of structurally and functionally interacting neurons, neuronal populations, and macroscopic brain areas. This shift in…

神经元与认知 · 定量生物学 2020-10-06 Richard Betzel

Protein-Protein Interaction Networks aim to model the interactome, providing a powerful tool for understanding the complex relationships governing cellular processes. These networks have numerous applications, including functional…

分子网络 · 定量生物学 2023-10-05 Rodrigo Henrique Ramos , Cynthia de Oliveira Lage Ferreira , Adenilso Simao

Understanding the origins of complexity is a fundamental challenge with implications for biological and technological systems. Network theory emerges as a powerful tool to model complex systems. Networks are an intuitive framework to…

无序系统与神经网络 · 物理学 2024-10-22 Blai Vidiella , Salva Duran-Nebreda , Sergi Valverde

The human organism is an integrated network where complex physiologic systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and…

数据分析、统计与概率 · 物理学 2012-03-02 Amir Bashan , Ronny P. Bartsch , Jan W. Kantelhardt , Shlomo Havlin , Plamen Ch. Ivanov

Topological Deep Learning seeks to enhance the predictive performance of neural network models by harnessing topological structures in input data. Topological neural networks operate on spaces such as cell complexes and hypergraphs, that…

Network topology is a fundamental aspect of network science that allows us to gather insights into the complicated relational architectures of the world we inhabit. We provide a first specific study of neighbourhood degree sequences in…

社会与信息网络 · 计算机科学 2019-06-11 Keith M. Smith

From interacting cellular components to networks of neurons and neural systems, interconnected units comprise a fundamental organizing principle of the nervous system. Understanding how their patterns of connections and interactions give…

神经元与认知 · 定量生物学 2018-08-01 Danielle S. Bassett , Perry Zurn , Joshua I. Gold

We propose a novel and efficient algorithm to model high-level topological structures of neuronal fibers. Tractography constructs complex neuronal fibers in three dimensions that exhibit the geometry of white matter pathways in the brain.…

计算机视觉与模式识别 · 计算机科学 2021-08-04 S. Shailja , Angela Zhang , B. S. Manjunath

Most complex systems can be captured by graphs or networks. Networks connect nodes (e.g.\ neurons) through edges (synapses), thus summarizing the system's structure. A popular way of interrogating graphs is community detection, which…

物理与社会 · 物理学 2024-09-23 Luis F Seoane

Novel experimental techniques reveal the simultaneous activity of larger and larger numbers of neurons. As a result there is increasing interest in the structure of cooperative -- or correlated -- activity in neural populations, and in the…

神经元与认知 · 定量生物学 2015-05-30 James Trousdale , Yu Hu , Eric Shea-Brown , Krešimir Josić

In this article we investigate the topological changes undergone by trajectory networks as a consequence of progressive geographical infiltration. Trajectory networks, a type of knitted network, are obtained by establishing paths between…

离散数学 · 计算机科学 2008-04-21 Luciano da Fontoura Costa

This article describes the application of recently introduced complex networks concepts and methods to the characterization and analysis of cortical bone structure. Three-dimensional reconstructions of the system of channels underlying bone…

组织与器官 · 定量生物学 2007-05-23 Luciano da Fontoura Costa , Matheus Palhares Viana , Marcelo Emilio Beletti

Neurons in the brain are spatially organized such that neighbors on tissue often exhibit similar response profiles. In the human language system, experimental studies have observed clusters for syntactic and semantic categories, but the…

计算与语言 · 计算机科学 2025-05-16 Neil Rathi , Johannes Mehrer , Badr AlKhamissi , Taha Binhuraib , Nicholas M. Blauch , Martin Schrimpf

Neural network models capable of storing memory have been extensively studied in computer science and computational neuroscience. The Hopfield network is a prototypical example of a model designed for associative, or content-addressable,…

神经元与认知 · 定量生物学 2025-09-24 Marco Cafiso , Paolo Paradisi

The hippocampal-entorhinal complex plays a major role in the organization of memory and thought. The formation of and navigation in cognitive maps of arbitrary mental spaces via place and grid cells can serve as a representation of memories…

神经元与认知 · 定量生物学 2022-10-31 Paul Stoewer , Achim Schilling , Andreas Maier , Patrick Krauss

A small-world topology characterizes many complex systems including the structural and functional organization of brain networks. The topology allows simultaneously for local and global efficiency in the interaction of the system…

物理与社会 · 物理学 2015-05-30 Sinisa Pajevic , Dietmar Plenz

Recent developments in network neuroscience have highlighted the importance of developing techniques for analyzing and modeling brain networks. A particularly powerful approach for studying complex neural systems is to formulate generative…

神经元与认知 · 定量生物学 2022-09-09 Viplove Arora , Enrico Amico , Joaquín Goñi , Mario Ventresca

Partial synchronization plays a crucial role in the functioning of neuronal networks: selective, coordinated activation of neurons enables information processing that flexibly adapts to a changing computational context. Since the structure…

神经元与认知 · 定量生物学 2025-06-17 Daniil Radushev , Olesia Dogonasheva , Boris Gutkin , Denis Zakharov

One of the essential tasks in connectomics is the morphology analysis of neurons and organelles like mitochondria to shed light on their biological properties. However, these biological objects often have tangled parts or complex branching…

计算机视觉与模式识别 · 计算机科学 2020-04-22 Abhimanyu Talwar , Zudi Lin , Donglai Wei , Yuesong Wu , Bowen Zheng , Jinglin Zhao , Won-Dong Jang , Xueying Wang , Jeff W. Lichtman , Hanspeter Pfister