相关论文: Modeling the impact of host diversity on the evolu…
The emergence or adaptation of pathogens may lead to epidemics, highlighting the need for a thorough understanding of pathogen evolution. The tradeoff hypothesis suggests that virulence evolves to reach an optimal transmission intensity…
In this paper we propose a method to study a general vector-hosts mathematical model in order to explain how the changes in biodiversity could influence the dynamics of vector-borne diseases. We find that under the assumption of…
Is it possible to break the host-vector chain of transmission when there is an influx of infectious hosts into a na\"{i}ve population and competent vector? To address this question, a class of vector-borne disease models with an arbitrary…
We propose an epidemic model for the spread of vector-borne diseases. The model, which is built extending the classical susceptible-infected-susceptible model, accounts for two populations -- humans and vectors -- and for cross-contagion…
Since the last century, deterministic compartmental models have emerged as powerful tools to predict and control epidemic outbreaks, in many cases helping to mitigate their impacts. A key quantity for these models is the so-called Basic…
A current challenge for disease modeling and public health is understanding pathogen dynamics across scales since their ecology and evolution ultimately operate on several coupled scales. This is particularly true for vector-borne diseases,…
A looming challenge for agriculture is sustainable intensification of food production to feed the growing human population. Current chemical and genetic technologies used to manage plant diseases are highly vulnerable to pathogen evolution…
Vector-borne diseases arise from the coupled dynamics of human mobility and mosquito ecology, producing outbreaks shaped by both spatial distributions and temporal patterns of movement. Here we develop a coarse-grained hub--leaf reduction…
Chronic viral infections can persist in an infected person for decades. From the perspective of the virus, a single infection can span thousands of generations, leading to a highly diverse population of viruses with its own complex…
We investigate a model for a mosquito-borne epidemic in which human hosts may adopt protective behaviour against vector bites in response to information on both past and current disease prevalence. Assuming that mosquitoes can also feed on…
A multi-patch and multi-group modeling framework describing the dynamics of a class of diseases driven by the interactions between vectors and hosts structured by groups is formulated. Hosts' dispersal is modeled in terms of patch-residence…
We investigate how key epidemiological parameters shape both seasonal epidemics and the persistence of dengue transmission. Our findings confirm known mechanistic drivers of epidemic variability and introduce a ranking of parameter…
We use a multitype continuous time Markov branching process model to describe the dynamics of the spread of parasites of two types that can mutate into each other in a common host population. Instead of using a single virulence…
Stochastic epidemic models, generally more realistic than deterministic counterparts, have often been seen too complex for rigorous mathematical analysis because of level of details it requires to comprehensively capture the dynamics of…
Human pathogens transmitted through environmental pathways are subject to stress and pressures outside of the host. These pressures may cause pathogen pathovars to diverge in their environmental persistence and their infectivity on an…
Many vector-borne disease epidemic models neglect the fact that in modern human civilization, social awareness as well as self-defence system are overwhelming against advanced propagation of the disease. News are becoming more effortlessly…
Despite being similar in structure, functioning, and size viral pathogens enjoy very different mostly well-defined ways of life. They occupy their hosts for a few days (influenza), for a few weeks (measles), or even lifelong (HCV), which…
Infectious disease dynamics operate across multiple biological scales, with within-host viral dynamics being a key driver of between-host transmission. However, while models that explicitly link these scales exist, none have been developed…
Dengue continues to pose a major global threat, infecting nearly 390 million people annually. Recognizing the pivotal role of vector competence (vc), recent research focuses on mosquito parameters to inform transmission modeling and vector…
A wide range of infectious diseases are both vertically and horizontally transmitted. Such diseases are spatially transmitted via multiple species in heterogeneous environments, typically described by complex meta-population models. The…