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We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused…

机器学习 · 计算机科学 2020-04-01 Sebastian Pölsterl , Ignacio Sarasua , Benjamín Gutiérrez-Becker , Christian Wachinger

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease characterized by progressive cognitive decline as its main symptom. In the research field of deep learning-assisted diagnosis of AD, traditional convolutional neural…

图像与视频处理 · 电气工程与系统科学 2025-07-15 Yang Ming , Jiang Shi Zhong , Zhou Su Juan

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which pathological changes begin many years before the onset of clinical symptoms, making early detection essential for timely intervention. T1-weighted (T1w) Magnetic…

计算机视觉与模式识别 · 计算机科学 2026-01-21 Jason Qiu

Machine learning algorithms underpin modern diagnostic-aiding software, which has proved valuable in clinical practice, particularly in radiology. However, inaccuracies, mainly due to the limited availability of clinical samples for…

Stacking excessive layers in DNN results in highly underdetermined system when training samples are limited, which is very common in medical applications. In this regard, we present a framework capable of deriving an efficient…

机器学习 · 计算机科学 2025-03-04 Seunghun Baek , Injun Choi , Mustafa Dere , Minjeong Kim , Guorong Wu , Won Hwa Kim

Alzheimer's disease (AD) is a neurodegenerative disorder marked by memory loss and cognitive decline, making early detection vital for timely intervention. However, early diagnosis is challenging due to the heterogeneous presentation of…

神经元与认知 · 定量生物学 2025-09-24 Ali Khazaee , Abdolreza Mohammadi , Ruairi O'Reilly

Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…

计算机视觉与模式识别 · 计算机科学 2021-03-01 Kuo Yang , Emad A. Mohammed , Behrouz H. Far

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related…

机器学习 · 计算机科学 2016-07-05 Ehsan Hosseini-Asl , Georgy Gimel'farb , Ayman El-Baz

Identifying and utilising various biomarkers for tracking Alzheimer's disease (AD) progression have received many recent attentions and enable helping clinicians make the prompt decisions. Traditional progression models focus on extracting…

机器学习 · 计算机科学 2023-11-08 Xulong Wang , Yu Zhang , Menghui Zhou , Tong Liu , Jun Qi , Po Yang

In this paper we describe and validate a longitudinal method for whole-brain segmentation of longitudinal MRI scans. It builds upon an existing whole-brain segmentation method that can handle multi-contrast data and robustly analyze images…

计算机视觉与模式识别 · 计算机科学 2023-02-13 Stefano Cerri , Douglas N. Greve , Andrew Hoopes , Henrik Lundell , Hartwig R. Siebner , Mark Mühlau , Koen Van Leemput

Deep learning methods have significantly advanced medical image segmentation, yet their success hinges on large volumes of manually annotated data, which require specialized expertise for accurate labeling. Additionally, these methods often…

图像与视频处理 · 电气工程与系统科学 2024-09-04 Wangang Cheng , Guanghua He , Keli Hu , Mingyu Fang , Liang Dong , Zhong Li , Hancan Zhu

Accurate diagnosis of Alzheimer's disease (AD) is both challenging and time consuming. With a systematic approach for early detection and diagnosis of AD, steps can be taken towards the treatment and prevention of the disease. This study…

机器学习 · 计算机科学 2022-12-12 Harshit Parmar , Eric Walden

Understanding the interactions between biomarkers among brain regions during neurodegenerative disease is essential for unravelling the mechanisms underlying disease progression. For example, pathophysiological models of Alzheimer's Disease…

Deep learning has been successful in predicting neurodegenerative disorders, such as Alzheimer's disease, from magnetic resonance imaging (MRI). Combining multiple imaging modalities, such as T1-weighted (T1) and diffusion-weighted imaging…

The aging population of the U.S. drives the prevalence of Alzheimer's disease. Brookmeyer et al. forecasts approximately 15 million Americans will have either clinical AD or mild cognitive impairment by 2060. In response to this urgent…

图像与视频处理 · 电气工程与系统科学 2023-12-01 Long Chen , Liben Chen , Binfeng Xu , Wenxin Zhang , Narges Razavian

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

计算机视觉与模式识别 · 计算机科学 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

Objective: This study aims to support early diagnosis of Alzheimer's disease and detection of amyloid accumulation by leveraging the microstructural information available in multi-shell diffusion MRI (dMRI) data, using a vision…

计算机视觉与模式识别 · 计算机科学 2026-01-08 Quentin Dessain , Nicolas Delinte , Bernard Hanseeuw , Laurence Dricot , Benoît Macq

Multimodal neuroimage can provide complementary information about the dementia, but small size of complete multimodal data limits the ability in representation learning. Moreover, the data distribution inconsistency from different…

计算机视觉与模式识别 · 计算机科学 2021-07-22 Qiankun Zuo , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang

The detection of Alzheimers disease (AD) is considered crucial, as timely intervention can improve patient outcomes. Electroencephalogram (EEG)-based diagnosis has been recognized as a non-invasive, accessible, and cost-effective approach…

Alzheimer's Disease (AD) is a progressive neurological disorder that can result in significant cognitive impairment and dementia. Accurate and timely diagnosis is essential for effective treatment and management of this disease. In this…

图像与视频处理 · 电气工程与系统科学 2024-12-10 Mozhgan Naderi , Maryam Rastgarpour , Amir Reza Takhsha