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Phylogenetic trees are key data objects in biology, and the method of phylogenetic reconstruction has been highly developed. The space of phylogenetic trees is a nonpositively curved metric space. Recently, statistical methods to analyze…

统计方法学 · 统计学 2022-11-23 Yuki Takazawa , Tomonari Sei

As costs of genome sequencing have dropped precipitously, development of efficient bioinformatic methods to analyze genome structure and evolution have become ever more urgent. For example, most published phylogenomic studies involve either…

种群与进化 · 定量生物学 2015-06-02 Grady Weyenberg , Ruriko Yoshida , Daniel Howe

The estimation of a log-concave density on $\mathbb{R}$ is a canonical problem in the area of shape-constrained nonparametric inference. We present a Bayesian nonparametric approach to this problem based on an exponentiated Dirichlet…

统计理论 · 数学 2020-07-14 Ester Mariucci , Kolyan Ray , Botond Szabo

The phylogenetic tree space introduced by Billera, Holmes, and Vogtmann (BHV tree space) is a CAT(0) continuous space that represents trees with edge weights with an intrinsic geodesic distance measure. The geodesic distance measure unique…

In Statistics, log-concave density estimation is a central problem within the field of nonparametric inference under shape constraints. Despite great progress in recent years on the statistical theory of the canonical estimator, namely the…

统计计算 · 统计学 2023-03-01 Wenyu Chen , Rahul Mazumder , Richard J. Samworth

We tackle the problem of high-dimensional nonparametric density estimation by taking the class of log-concave densities on $\mathbb{R}^p$ and incorporating within it symmetry assumptions, which facilitate scalable estimation algorithms and…

统计理论 · 数学 2019-03-15 Min Xu , Richard J. Samworth

The reliability of a phylogenetic inference method from genomic sequence data is ensured by its statistical consistency. Bayesian inference methods produce a sample of phylogenetic trees from the posterior distribution given sequence data.…

度量几何 · 数学 2016-06-10 Alex Gavryushkin , Alexei J. Drummond

In recent years, log-concave density estimation via maximum likelihood estimation has emerged as a fascinating alternative to traditional nonparametric smoothing techniques, such as kernel density estimation, which require the choice of one…

统计方法学 · 统计学 2017-09-12 Richard J. Samworth

Inferential summaries of tree estimates are useful in the setting of evolutionary biology, where phylogenetic trees have been built from DNA data since the 1960's. In bioinformatics, psychometrics and data mining, hierarchical clustering…

应用统计 · 统计学 2010-06-08 John Chakerian , Susan Holmes

It is common, in deconvolution problems, to assume that the measurement errors are identically distributed. In many real-life applications, however, this condition is not satisfied and the deconvolution estimators developed for…

统计理论 · 数学 2008-12-18 Aurore Delaigle , Alexander Meister

We develop an analysis pipeline for characterizing the topology of large scale structure and extracting cosmological constraints based on persistent homology. Persistent homology is a technique from topological data analysis that quantifies…

宇宙学与河外天体物理 · 物理学 2021-06-14 Matteo Biagetti , Alex Cole , Gary Shiu

This paper investigates the computational geometry relevant to calculations of the Frechet mean and variance for probability distributions on the phylogenetic tree space of Billera, Holmes and Vogtmann, using the theory of probability…

度量几何 · 数学 2014-02-18 Ezra Miller , Megan Owen , J. Scott Provan

Computational inference of dated evolutionary histories relies upon various hypotheses about RNA, DNA, and protein sequence mutation rates. Using mutation rates to infer these dated histories is referred to as molecular clock assumption.…

种群与进化 · 定量生物学 2021-01-11 Lena Collienne , Kieran Elmes , Mareike Fischer , David Bryant , Alex Gavryushkin

We address the problem of estimating topological features from data in high dimensional Euclidean spaces under the manifold assumption. Our approach is based on the computation of persistent homology of the space of data points endowed with…

机器学习 · 统计学 2023-01-23 Ximena Fernández , Eugenio Borghini , Gabriel Mindlin , Pablo Groisman

The paper considers nonparametric kernel density/regression estimation from a stochastic optimization point of view. The estimation problem is represented through a family of stochastic optimization problems. Recursive constrained…

统计理论 · 数学 2024-09-05 Vladimir Norkin , Vladimir Kirilyuk

We describe the use of the Frechet mean and variance in the Billera-Holmes-Vogtmann (BHV) treespace to summarize and explore the diversity of a set of phylogenetic trees. We show that the Frechet mean is comparable to other summary methods,…

种群与进化 · 定量生物学 2018-05-14 Daniel G. Brown , Megan Owen

Consistency of the kernel density estimator requires that the kernel bandwidth tends to zero as the sample size grows. In this paper we investigate the question of whether consistency is possible when the bandwidth is fixed, if we consider…

机器学习 · 统计学 2017-05-30 Efrén Cruz Cortés , Clayton Scott

One key issue in several astrophysical problems is the evaluation of the density probability function underlying an observational discrete data set. We here review two non-parametric density estimators which recently appeared in the…

天体物理学 · 物理学 2009-10-30 Dario Fadda , Eric Slezak , Albert Bijaoui

When analyzing modern machine learning algorithms, we may need to handle kernel density estimation (KDE) with intricate kernels that are not designed by the user and might even be irregular and asymmetric. To handle this emerging challenge,…

统计理论 · 数学 2021-06-09 Hau-Tieng Wu , Nan Wu

We study the problem of estimating linear response statistics under external perturbations using time series of unperturbed dynamics. Based on the fluctuation-dissipation theory, this problem is reformulated as an unsupervised learning task…

统计理论 · 数学 2020-12-09 He Zhang , John Harlim , Xiantao Li
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