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The recent COVID-19 pandemic has shown that when the reproduction number is high and there are no proper measurements in place, the number of infected people can increase dramatically in a short time, producing a phenomenon that many…

种群与进化 · 定量生物学 2022-09-20 Jonathan A. Chávez Casillas

The COVID-19 pandemic provides new motivation for a classic problem in epidemiology: estimating the empirical rate of transmission during an outbreak (formally, the time-varying reproduction number) from case counts. While standard methods…

统计方法学 · 统计学 2020-12-08 Bryan Wilder , Michael J. Mina , Milind Tambe

We propose a new method to estimate the time-varying effective (or instantaneous) reproduction number of the novel coronavirus disease (COVID-19). The method is based on a discrete-time stochastic augmented compartmental model that…

定量方法 · 定量生物学 2022-04-27 A. Hasan , H. Susanto , V. R. Tjahjono , R. Kusdiantara , E. R. M. Putri , P. Hadisoemarto , N. Nuraini

Standard epidemiological models for COVID-19 employ variants of compartment (SIR) models at local scales, implicitly assuming spatially uniform local mixing. Here, we examine the effect of employing more geographically detailed diffusion…

Early estimates of the transmission potential of emerging and re-emerging infections are increasingly used to inform public health authorities on the level of risk posed by outbreaks. Existing methods to estimate the reproduction number…

定量方法 · 定量生物学 2016-10-10 Gerardo Chowell , Cécile Viboud , Lone Simonsen , Seyed Moghadas

The effect of spatial correlations on the spread of infectious diseases was investigated using a stochastic SIR (Susceptible-Infective-Recovered) model on complex networks. It was found that in addition to the reduction of the effective…

种群与进化 · 定量生物学 2007-05-23 J. Verdasca , M. M. Telo da Gama , A. Nunes , N. R. Bernardino , J. M. Pacheco , M. C. Gomes

A discrete spatial lattice can be cast as a network structure over which spatially-correlated outcomes are observed. A second network structure may also capture similarities among measured features, when such information is available.…

统计方法学 · 统计学 2024-12-17 Arjun Sondhi , Si Cheng , Ali Shojaie

With the outbreak of the COVID-19 pandemic, various studies have focused on predicting the trajectory and risk factors of the virus and its variants. Building on previous work that addressed this problem using genetic and epidemiological…

应用统计 · 统计学 2023-12-25 Catherine Li , Daniel Lazarev

In this article, we investigate the importance of demographic and contact patterns in determining the spread of COVID-19 and to the effectiveness of social distancing policies. We investigate these questions proposing an augmented…

种群与进化 · 定量生物学 2022-05-12 M. A. Ridenti , L. K. Teles , A. Maranhão , V. K. Teles

In this paper, we provide a straightforward approach to defining and deriving the key epidemiological quantity, the basic reproduction number, $R_0$, for Markovian epidemics in structured populations. The methodology derived is applicable…

种群与进化 · 定量生物学 2019-03-26 Peter Neal , Thitiya Theparod

The pandemic linked to COVID-19 infection represents an unprecedented clinical and healthcare challenge for many medical researchers attempting to prevent its worldwide spread. This pandemic also represents a major challenge for…

Accurate numbers are needed to understand and predict viral dynamics. Curation of high-quality literature values for the infectious period duration or household secondary attack rate, for example, is especially pressing currently because…

其他定量生物学 · 定量生物学 2020-07-10 Yinon M. Bar-On , Ron Sender , Avi I. Flamholz , Rob Phillips , Ron Milo

The time-varying reproduction number $R(t)$ measures the number of new infections per infectious individual and is closely correlated with the time series of infection incidence by definition. The timings of actual infections are rarely…

种群与进化 · 定量生物学 2023-07-10 Oliver Eales , Steven Riley

The World Health Organisation (WHO) has very strongly recommended testing and isolation as a strategy for controlling the ongoing COVID-19 pandemic. The goal of this paper is to quantify the effects of detection and isolation in formal…

种群与进化 · 定量生物学 2020-06-09 Palash Sarkar

This paper presents a detailed mathematical investigation into the dynamics of COVID-19 infections through extended Susceptible-Infected-Recovered (SIR) and Susceptible-Exposed-Infected-Recovered (SEIR) epidemiological models. By…

种群与进化 · 定量生物学 2025-05-21 Caleb Traxler , Minh Ton , Nameer Ahmed , Sasha Prostota , Annie Cheng

Understanding how age-specific social contact patterns and susceptibility influence infectious disease transmission is crucial for accurate epidemic modeling. This study presents an eigenvector-based sensitivity analysis framework to…

种群与进化 · 定量生物学 2025-11-21 Evans Kiptoo Korir , Zsolt Vizi

We study the reported data from the COVID-19 pandemic outbreak in January - May 2020 in 119 countries. We observe that the time series of active cases in individual countries (the difference of the total number of confirmed infections and…

种群与进化 · 定量生物学 2020-05-15 Katarina Bodova , Richard Kollar

Raw data on the cumulative number of deaths at a country level generally indicate a spatially variable distribution of the incidence of COVID-19 disease. An important issue is to determine whether this spatial pattern is a consequence of…

种群与进化 · 定量生物学 2020-07-21 Lionel Roques , Olivier Bonnefon , Virgile Baudrot , Samuel Soubeyrand , Henri Berestycki

With the covid-19 pandemic still ongoing and an enormous amount of test data available, the lessons learned over the last two years need to be developed to a point where they can provide understanding for tackling new variants and future…

种群与进化 · 定量生物学 2022-06-09 Adam Mielke

As countries look towards re-opening of economic activities amidst the ongoing COVID-19 pandemic, ensuring public health has been challenging. While contact tracing only aims to track past activities of infected users, one path to safe…

机器学习 · 计算机科学 2020-12-15 Sirisha Rambhatla , Sepanta Zeighami , Kameron Shahabi , Cyrus Shahabi , Yan Liu