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Biofilament-motor protein complexes are ubiquitous in biology and drive the transport of cargo vital for many fundamental cellular processes. As they move, motor proteins exert compressive forces on the filaments to which they are attached,…

生物物理 · 物理学 2024-06-12 Bethany Clarke , Yongyun Hwang , Eric Keaveny

Active gels are a class of biologically-relevant material containing embedded agents that spontaneously generate forces acting on a sparse filament network. In vitro experiments of protein filaments and molecular motors have revealed a…

软凝聚态物质 · 物理学 2024-06-03 David A. Head , Gerhard Gompper , W. J. Briels

The cytoskeleton is an important subsystem of cells that is involved for example in cell division and locomotion. It consists of filaments that are cross-linked by molecular motors that can induce relative sliding between filaments and…

统计力学 · 物理学 2007-08-08 P. K. Mohanty , K. Kruse

Using a simple model, we study the fluctuating dynamics of inextensible, semiflexible polar filaments interacting with active and directed force generating centres such as molecular motors. Taking into account the fact that the activity…

软凝聚态物质 · 物理学 2009-11-07 Tanniemola B. Liverpool

We study the onset of spontaneous dynamics in the follower force model of an active filament, wherein a slender elastic filament in a viscous liquid is clamped normal to a wall at one end and subjected to a tangential compressive force at…

流体动力学 · 物理学 2025-04-02 Ory Schnitzer

In the presence of ATP, molecular motors generate active force dipoles that drive suspensions of protein filaments far from thermodynamic equilibrium, leading to exotic dynamics and pattern formation. Microscopic modelling can help to…

生物物理 · 物理学 2015-06-17 D. A. Head , W. J. Briels , G. Gompper

Intermediate filaments form an essential structural network, spread throughout the cytoplasm and play a key role in cell mechanics, intracellular organization and molecular signaling. The maintenance of the network and its adaptation to the…

亚细胞过程 · 定量生物学 2023-06-14 Youngmin Park , Cécile Leduc , Sandrine Etienne-Manneville , Stéphanie Portet

In cells, cytoskeletal filament networks are responsible for cell movement, growth, and division. Filaments in the cytoskeleton are driven and organized by crosslinking molecular motors. In reconstituted cytoskeletal systems, motor activity…

In this work, we compare the structural and dynamic behavior of active filaments in two dimensions using tangential and push-pull models, including a variant with passive end monomers. These models serve as valuable frameworks for…

Fluid-structure interactions between active and passive components are important for many biological systems to function. A particular example is chromatin in the cell nucleus, where ATP-powered processes drive coherent motions of the…

软凝聚态物质 · 物理学 2024-02-15 Scott Weady , David B. Stein , Alexandra Zidovska , Michael J. Shelley

It is known from the wave-like motion of microtubules in motility assays that the piconewton forces that motors produce can be sufficient to bend the filaments. In cellular phenomena such as cytosplasmic streaming, molecular motors…

软凝聚态物质 · 物理学 2017-07-11 Gabriele De Canio , Eric Lauga , Raymond E. Goldstein

The fluid-structure interactions between flexible fibers and viscous flows play an essential role in various biological phenomena, medical problems, and industrial processes. Of particular interest is the case of particles freely…

流体动力学 · 物理学 2023-02-01 Francesco Bonacci , Brato Chakrabarti , David Saintillan , Olivia du Roure , Anke Lindner

We study the over-damped dynamics of individual one-dimensional elastic filaments subjected to a chiral active force which propels each point of the filament at a fixed angle relative to the tangent vector of the filament at that point.…

软凝聚态物质 · 物理学 2026-03-09 Chanania Steinbock , Daniel A. Beller

We simulate the nonlocal Stokesian hydrodynamics of an elastic filament which is active due a permanent distribution of stresslets along its contour. A bending instability of an initially straight filament spontaneously breaks flow symmetry…

We use Langevin dynamics simulations to study dynamical behaviour of a dense planar layer of active semi-flexible filaments. Using the strength of active force and the thermal persistence length as parameters, we map a detailed phase…

软凝聚态物质 · 物理学 2018-02-21 K. R. Prathyusha , Silke Henkes , Rastko Sknepnek

Active matter systems evade the constraints of thermal equilibrium, leading to the emergence of intriguing collective behavior. A paradigmatic example is given by motor-filament mixtures, where the motion of motor proteins drives alignment…

软凝聚态物质 · 物理学 2024-09-11 Filippo De Luca , Ivan Maryshev , Erwin Frey

Recent experimental realizations of liquid-liquid phase separation of active liquid crystals have offered an insight into the interaction between phase separation, ubiquitous in soft matter and biology, and chaotic active flows. In this…

软凝聚态物质 · 物理学 2025-04-23 Paarth Gulati , Fernando Caballero , M. Cristina Marchetti

We analyze a model of mutually-propelled filaments suspended in a two-dimensional solvent. The system undergoes a mean-field isotropic-nematic transition for large enough filament concentrations and the nematic order parameter is allowed to…

软凝聚态物质 · 物理学 2011-05-26 L. Giomi , L. Mahadevan , B. Chakraborty , M. F. Hagan

The morphological dynamics, instabilities and transitions of elastic filaments in viscous flows underlie a wealth of biophysical processes from flagellar propulsion to intracellular streaming, and are also key to deciphering the rheological…

流体动力学 · 物理学 2018-11-09 Yanan Liu , Brato Chakrabarti , David Saintillan , Anke Lindner , Olivia du Roure

Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel…

生物物理 · 物理学 2016-06-21 J. Gladrow , N. Fakhri , F. C. MacKintosh , C. F. Schmidt , C. P. Broedersz
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