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Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning methods that relax these constraints, comparing their performance with penalized Cox models…

机器学习 · 计算机科学 2025-10-21 Ivan Rossi , Flavio Sartori , Cesare Rollo , Giovanni Birolo , Piero Fariselli , Tiziana Sanavia

A series of monte carlo studies were performed to assess the extent to which different inference procedures robustly output reasonable belief values in the context of increasing levels of judgmental imprecision. It was found that, when…

人工智能 · 计算机科学 2013-04-05 Paul E. Lehner

Statistical inference of the high-dimensional regression coefficients is challenging because the uncertainty introduced by the model selection procedure is hard to account for. A critical question remains unsettled; that is, is it possible…

统计方法学 · 统计学 2025-01-06 Xiaorui Zhu , Yichen Qin , Peng Wang

This paper considers the empirical likelihood (EL) construction of confidence intervals for a linear functional based on right censored lifetime data. Many of the results in literature show that log EL has a limiting scaled chi-square…

统计理论 · 数学 2012-03-28 Shuyuan He , Wei Liang , Junshan Shen , Grace Yang

In this paper, we propose a data-adaptive empirical likelihood-based approach for treatment effect estimation and inference, which overcomes the obstacle of the traditional empirical likelihood-based approaches in the high-dimensional…

统计方法学 · 统计学 2020-12-15 Wei Liang , Ying Yan

Penalized likelihood models are widely used to simultaneously select variables and estimate model parameters. However, the existence of weak signals can lead to inaccurate variable selection, biased parameter estimation, and invalid…

统计方法学 · 统计学 2022-12-13 Yuexia Zhang , Peibei Shi , Zhongyi Zhu , Linbo Wang , Annie Qu

Empirical likelihood enables a nonparametric, likelihood-driven style of inference without restrictive assumptions routinely made in parametric models. We develop a framework for applying empirical likelihood to the analysis of experimental…

统计方法学 · 统计学 2023-11-08 Eunseop Kim , Steven N. MacEachern , Mario Peruggia

Mechanistic dynamic models of biochemical networks such as Ordinary Differential Equations (ODEs) contain unknown parameters like the reaction rate constants and the initial concentrations of the compounds. The large number of parameters as…

数据分析、统计与概率 · 物理学 2017-08-14 Clemens Kreutz , Andreas Raue , Jens Timmer

Cox's proportional hazards model is one of the most popular statistical models to evaluate associations of exposure with a censored failure time outcome. When confounding factors are not fully observed, the exposure hazard ratio estimated…

统计方法学 · 统计学 2022-01-04 Linbo Wang , Eric Tchetgen Tchetgen , Torben Martinussen , Stijn Vansteelandt

Confounding control is crucial and yet challenging for causal inference based on observational studies. Under the typical unconfoundness assumption, augmented inverse probability weighting (AIPW) has been popular for estimating the average…

统计方法学 · 统计学 2023-01-27 Eunah Cho , Shu Yang

Tree-based priors for probability distributions are usually specified using a predetermined, data-independent collection of candidate recursive partitions of the sample space. To characterize an unknown target density in detail over the…

统计方法学 · 统计学 2025-04-14 Li Ma , Benedetta Bruni

Background: The hazard ratio of the Cox proportional hazards model is widely used in randomized controlled trials to assess treatment effects. However, two properties of the hazard ratio including the non-collapsibility and built-in…

统计方法学 · 统计学 2024-01-17 Helen Bian , Menglan Pang , Guanbo Wang , Zihang Lu

Fisher's likelihood is widely used for statistical inference for fixed unknowns. This paper aims to extend two important likelihood-based methods, namely the maximum likelihood procedure for point estimation and the confidence procedure for…

统计理论 · 数学 2025-03-03 Hangbin Lee , Youngjo Lee

In observational studies with survival or time-to-event outcomes, a propensity score weighted marginal Cox proportional hazard model with the treatment variable as the only predictor is commonly used to estimate the causal marginal hazard…

统计方法学 · 统计学 2026-02-02 Zixian Zhao , Chengxin Yang , Fan Li

For a multivariate linear model, Wilk's likelihood ratio test (LRT) constitutes one of the cornerstone tools. However, the computation of its quantiles under the null or the alternative requires complex analytic approximations and more…

统计方法学 · 统计学 2018-01-23 Z. Bai , D. Jiang , J. Yao , S. Zheng

I propose a nonparametric iid bootstrap procedure for the empirical likelihood, the exponential tilting, and the exponentially tilted empirical likelihood estimators that achieves asymptotic refinements for t tests and confidence intervals,…

计量经济学 · 经济学 2026-02-03 Seojeong Lee

The problem of how to best select variables for confounding adjustment forms one of the key challenges in the evaluation of exposure effects in observational studies, and has been the subject of vigorous recent activity in causal inference.…

统计方法学 · 统计学 2021-12-02 Kelly Van Lancker , Oliver Dukes , Stijn Vansteelandt

Many methods of estimating causal models do not provide estimates of confidence in the resulting model. In this work, a metric is proposed for validating the output of a causal model fit; the robustness of the model structure with resampled…

This paper develops power and sample size formulas for causal inference with time-to-event outcomes. The target estimand is the marginal hazard ratio: the coefficient of a marginal structural Cox proportional hazard model with treatment as…

统计方法学 · 统计学 2026-05-19 Chengxin Yang , Bo Liu , Fan Li

In high energy physics, a widely used method to treat systematic uncertainties in confidence interval calculations is based on combining a frequentist construction of confidence belts with a Bayesian treatment of systematic uncertainties.…

数据分析、统计与概率 · 物理学 2009-11-10 Fredrik Tegenfeldt , Jan Conrad