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We characterize different cell states, related to cancer and ageing phenotypes, by a measure of entropy of network ensembles, integrating gene expression values and protein interaction networks. The entropy measure estimates the parameter…

分子网络 · 定量生物学 2013-05-24 G. Menichetti , G. Bianconi , E. Giampieri , G. Castellani , D. Remondini

We give an explicit formula for the membrane potential of cells in terms of the intracellular and extracellular ionic concentrations, and derive equations for the ionic currents that flow through channels, exchangers and electrogenic pumps.…

生物物理 · 物理学 2007-05-23 L. P. Endresen , K. Hall , J. S. Hoye , J. Myrheim

Maximum entropy methods provide a principled path connecting measurements of neural activity directly to statistical physics models, and this approach has been successful for populations of $N\sim 100$ neurons. As $N$ increases in new…

生物物理 · 物理学 2023-10-18 Christopher W. Lynn , Qiwei Yu , Rich Pang , William Bialek , Stephanie E. Palmer

Sleep stage classification is a widely discussed topic, due to its importance in the diagnosis of sleep disorders, e.g. insomnia. Analysis of the brain activity during sleep is necessary to gain further insight into the processing that…

信号处理 · 电气工程与系统科学 2024-10-08 Alexander Edthofer , Iris Feldhammer , Thomas Fenzl , Andreas Körner , Matthias Kreuzer

In this work, we apply information theory inspired methods to quantify changes in daily activity patterns. We use in-home movement monitoring data and show how they can help indicate the occurrence of healthcare-related events. Three…

机器学习 · 计算机科学 2022-10-06 Yushan Huang , Yuchen Zhao , Hamed Haddadi , Payam Barnaghi

We measure different contributions to entropy production in a living functional epithelial tissue. We do this by extracting the functional dynamics of development while at the same time quantifying fluctuations. Using the translucent…

软凝聚态物质 · 物理学 2023-01-25 Mark Olenik , Jake Turley , Stephen Cross , Helen Weavers , Paul Martin , Isaac Chenchiah , Tanniemola Liverpool

Quantification of information content and its temporal variation in intracellular calcium spike trains in neurons helps one understand functions such as memory, learning, and cognition. Such quantification could also reveal pathological…

信号处理 · 电气工程与系统科学 2021-02-02 Sathish Ande , Srinivas Avasarala , Jayanth R Regatti , Neha Pandey , Sarpras Swain , Ajith Karunarathne , Lopamudra Giri , Soumya Jana

Previous measurements utilizing Maxwell relations to measure change in entropy, $S$, demonstrated remarkable accuracy of measuring the spin-1/2 entropy of electrons in a weakly coupled quantum dot. However, these previous measurements…

介观与纳米尺度物理 · 物理学 2022-04-06 Tim Child , Owen Sheekey , Silvia Lüscher , Saeed Fallahi , Geoffrey C. Gardner , Michael Manfra , Joshua Folk

The principle of maximum entropy provides a useful method for inferring statistical mechanics models from observations in correlated systems, and is widely used in a variety of fields where accurate data are available. While the assumptions…

神经元与认知 · 定量生物学 2017-06-02 Ulisse Ferrari , Tomoyuki Obuchi , Thierry Mora

We give an explicit formula for the membrane potential of cells in terms of the intracellular and extracellular ionic concentrations, and derive equations for the ionic currents that flow through channels, exchangers and electrogenic pumps…

生物物理 · 物理学 2007-05-23 Lars Petter Endresen , Kevin Hall

Entropy measures have become increasingly popular as an evaluation metric for complexity in the analysis of time series data, especially in physiology and medicine. Entropy measures the rate of information gain, or degree of regularity in a…

统计方法学 · 统计学 2015-12-03 Chee Chun Gan , Gerard Learmonth

In nonlinear dynamics, and to a lesser extent in other fields, a widely used measure of complexity is the Permutation Entropy. But there is still no known method to determine the accuracy of this measure. There has been little research on…

统计方法学 · 统计学 2017-11-22 Francisco Traversaro , Francisco Redelico

Entropy is one of the key thermodynamic variables reflecting changes in the state of matter. Unlike other thermodynamic variables, it is well-defined also for nonequilibrium steady states through its relation to information. Applying this…

统计力学 · 物理学 2026-04-15 Haim Diamant , Gil Ariel

Signals recorded from neurons with extracellular planar sensors have a wide range of waveforms and amplitudes. This variety is a result of different physical conditions affecting the ion currents through a cellular membrane. The…

A key challenge in systems biology is the elucidation of the underlying principles, or fundamental laws, which determine the cellular phenotype. Understanding how these fundamental principles are altered in diseases like cancer is important…

分子网络 · 定量生物学 2014-08-06 Andrew Teschendorff , Peter Sollich , Reimer Kuehn

Entropy is a central concept in physics, but can be challenging to calculate even for systems that are easily simulated. This is exacerbated out of equilibrium, where generally little is known about the distribution characterizing simulated…

统计力学 · 物理学 2024-05-09 Samuel D. Gelman , Guy Cohen

Magnetoencephalographic (MEG) measurements record magnetic fields generated from neurons while information is being processed in the brain. The inverse problem of identifying sources of biomagnetic fields and deducing their intensities from…

神经元与认知 · 定量生物学 2009-11-11 Hung-I Pai , Chih-Yuan Tseng , HC Lee

Entropy is a classical measure to quantify the amount of information or complexity of a system. Various entropy-based measures such as functional and spectral entropies have been proposed in brain network analysis. However, they are less…

神经元与认知 · 定量生物学 2018-03-08 Hyekyoung Lee , Eunkyung Kim , Hyejin Kang , Youngmin Huh , Youngjo Lee , Seonhee Lim , Dong Soo Lee

Living systems operate far from thermal equilibrium by converting the chemical potential of ATP into mechanical work to achieve growth, replication or locomotion. Given time series observations of intra-, inter- or multicellular processes,…

生物物理 · 物理学 2021-11-03 Dominic J. Skinner , Jörn Dunkel

We propose the use of entropy, measured from the spatial and flux distribution of pixels in the residual image, as a potential diagnostic and stopping metric for the CLEAN algorithm. Despite its broad success as the standard deconvolution…

天体物理仪器与方法 · 物理学 2023-11-10 D. C. Homan , J. S. Roth , A. B. Pushkarev
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