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Identifying molecular signatures from complex disease patients with underlying symptomatic similarities is a significant challenge in the analysis of high dimensional multi-omics data. Topological data analysis (TDA) provides a way of…

基因组学 · 定量生物学 2024-04-23 Davide Gurnari , Aldo Guzmán-Sáenz , Filippo Utro , Aritra Bose , Saugata Basu , Laxmi Parida

Effectively representing medical images, especially retinal images, presents a considerable challenge due to variations in appearance, size, and contextual information of pathological signs called lesions. Precise discrimination of these…

计算机视觉与模式识别 · 计算机科学 2024-12-24 Teja Krishna Cherukuri , Nagur Shareef Shaik , Dong Hye Ye

This paper proposes a new technique for automatic face recognition using integrated peaks of the Hough transformed significant blocks of the binary gradient image. In this approach firstly the gradient of an image is calculated and a…

计算机视觉与模式识别 · 计算机科学 2013-12-09 Arindam Kar , Debotosh Bhattacharjee , Dipak Kumar Basu , Mita Nasipuri , Mahantapas Kundu

In this paper, we study solution operators of physical field equations on geometric meshes from a function-space perspective. We reveal that Hodge orthogonality fundamentally resolves spectral interference by isolating unlearnable…

机器学习 · 计算机科学 2026-05-14 Dongzhe Zheng , Tao Zhong , Christine Allen-Blanchette

We propose an automatic diabetic retinopathy (DR) analysis algorithm based on two-stages deep convolutional neural networks (DCNN). Compared to existing DCNN-based DR detection methods, the proposed algorithm have the following advantages:…

计算机视觉与模式识别 · 计算机科学 2017-05-03 Yehui Yang , Tao Li , Wensi Li , Haishan Wu , Wei Fan , Wensheng Zhang

Understanding how the spatial structure of blood vessel networks relates to their function in healthy and abnormal biological tissues could improve diagnosis and treatment for diseases such as cancer. New imaging techniques can generate…

Feature engineering continues to play a critical role in image classification, particularly when interpretability and computational efficiency are prioritized over deep learning models with millions of parameters. In this study, we revisit…

计算机视觉与模式识别 · 计算机科学 2026-02-06 Abhijit Sen , Giridas Maiti , Bikram K. Parida , Bhanu P. Mishra , Mahima Arya , Denys I. Bondar

Topological Data Analysis (TDA) is a novel, and relatively new approach to analysing high-dimensional data sets. It does this by focussing on global properties like the shape and connectivity of the data giving it a significant advantage…

天体物理仪器与方法 · 物理学 2019-04-26 Jeff Murugan , Duncan Robertson

Convolutional neural networks (CNN) and Transformer variants have emerged as the leading medical image segmentation backbones. Nonetheless, due to their limitations in either preserving global image context or efficiently processing…

图像与视频处理 · 电气工程与系统科学 2023-05-26 Pengcheng Shi , Xutao Guo , Yanwu Yang , Chenfei Ye , Ting Ma

Fundus images are widely used for diagnosing various eye diseases, such as diabetic retinopathy, glaucoma, and age-related macular degeneration. However, manual analysis of fundus images is time-consuming and prone to errors. In this…

计算机视觉与模式识别 · 计算机科学 2024-12-30 Eric Shah , Jay Patel , Mr. Vishal Katheriya , Parth Pataliya

Topological data analysis (TDA) uses persistent homology to quantify loops and higher-dimensional holes in data, making it particularly relevant for examining the characteristics of images of cells in the field of cell biology. In the…

统计方法学 · 统计学 2024-05-06 Susan Glenn , Jessi Cisewski-Kehe , Jun Zhu , William M. Bement

Diabetic retinopathy (DR) grading is crucial in determining the adequate treatment and follow up of patients, but the screening process can be tiresome and prone to errors. Deep learning approaches have shown promising performance as…

图像与视频处理 · 电气工程与系统科学 2020-06-01 Teresa Araújo , Guilherme Aresta , Luís Mendonça , Susana Penas , Carolina Maia , Ângela Carneiro , Ana Maria Mendonça , Aurélio Campilho

Topological data analysis (TDA), while abstract, allows a characterization of time-series data obtained from nonlinear and complex dynamical systems. Though it is surprising that such an abstract measure of structure - counting pieces and…

计算几何 · 计算机科学 2020-01-07 Nicole Sanderson , Elliott Shugerman , Samantha Molnar , James D. Meiss , Elizabeth Bradley

Purpose To develop a computer based method for the automated assessment of image quality in the context of diabetic retinopathy (DR) to guide the photographer. Methods A deep learning framework was trained to grade the images automatically.…

计算机视觉与模式识别 · 计算机科学 2017-03-08 Sajib Kumar Saha , Basura Fernando , Jorge Cuadros , Di Xiao , Yogesan Kanagasingam

Graphs model latent variable relationships in many real-world systems, and Message Passing Neural Networks (MPNNs) are widely used to learn such structures for downstream tasks. While edge-based MPNNs effectively capture local interactions,…

机器学习 · 计算机科学 2025-11-27 Thomas Bailie , Yun Sing Koh , Karthik Mukkavilli

Alzheimer's disease (AD) emerges from a complex interplay of molecular, cellular, and network-level disturbances that are not easily captured by traditional reductionist frameworks. Conventional analyses of gene expression often rely on…

定量方法 · 定量生物学 2025-12-11 Aya Samadzelkava

The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and…

定量方法 · 定量生物学 2024-04-15 Zeyu Zhang , Yuanshen Zhao , Jingxian Duan , Yaou Liu , Hairong Zheng , Dong Liang , Zhenyu Zhang , Zhi-Cheng Li

Brain connectomics is still largely dominated by pairwise-based models, such as graphs, which cannot represent circulatory or higher-order functional interactions. In this paper, we propose a multimodal framework based on Topological Signal…

神经元与认知 · 定量生物学 2026-04-01 Breno C. Bispo , Stefania Sardellitti , Juliano B. Lima , Fernando A. N. Santos

Motivated by the challenging segmentation task of pancreatic tubular networks, this paper tackles two commonly encountered problems in biomedical imaging: Topological consistency of the segmentation, and expensive or difficult annotation.…

计算机视觉与模式识别 · 计算机科学 2023-06-29 Kasra Arnavaz , Oswin Krause , Kilian Zepf , Jelena M. Krivokapic , Silja Heilmann , Jakob Andreas Bærentzen , Pia Nyeng , Aasa Feragen

Image classification requires the generation of features capable of detecting image patterns informative of group identity. The objective of this study was to classify images from the public CIFAR-10 image dataset by leveraging combinations…

计算机视觉与模式识别 · 计算机科学 2020-03-02 Felipe O. Giuste , Juan C. Vizcarra