相关论文: An Integrated Lab on a CD Microfluidic Platform fo…
Microfluidic cytometers based on coulter principle have recently shown a great potential for point of care biosensors for medical diagnostics. In this study, the design of coulter based microfluidic cytometer is investigated by using…
We present a focal liver lesion detection model leveraged by custom-designed multi-phase computed tomography (CT) volumes, which reflects real-world clinical lesion detection practice using a Single Shot MultiBox Detector (SSD). We show…
Capillaries are the smallest vessels in the body responsible for delivering oxygen and nutrients to surrounding cells. Various life-threatening diseases are known to alter the density of healthy capillaries and the flow velocity of…
Biomedical and biochemical processes in paper-based microfluidic devices often deal with mixing of two analytes to perform important functions. Uniform mixing of analytes in paper matrix is a challenging proposition, often necessitating…
Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…
Bright-field microscopy, a cost-effective solution for live-cell culture, is often the only resource available, along with standard CPUs, for many low-budget labs. The inherent challenges of bright-field images -- their noisiness, low…
Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through…
We propose an arbitrarily high-order accurate, fully well-balanced numerical method for the one-dimensional blood flow model. The developed method employs a continuous solution representation, combining conservative and primitive…
We propose a portable cartridge based lab-on-a-chip platform. The main sensing mechanism uses high frequency acoustic waves. Feasibility of two different transducers has been investigated for biological measurements. We used zincoxide (ZnO)…
Deploying high-performing 3D medical image segmenters (e.g., nnU-Net) is often limited by memory footprint and inference latency. Compression is therefore necessary, but compact 3D encoders tend to lose fine structural cues (small lesions…
Spatial separation of suspended particles based on contrast in their physical or chemical properties forms the basis of various biological assays performed on lab-on-achip devices. To electronically acquire this information, we have…
Liquid-liquid phase separation plays a major role in the formation and maintenance of various membrane-less subcellular structures in the cytoplasm and nucleus of cells. Biological condensates contain enhanced concentrations of proteins and…
Blu-ray drive is an engineering masterpiece that integrates disc rotation, pickup head translation, and three lasers in a compact and portable format. Here we integrate a blood-coated image sensor with a modified Blu-ray drive for…
The size- and fluorescence-based sorting of micro- and nano-scale particles suspended in fluid presents a significant and important challenge for both sample analysis and for manufacturing of nanoparticle-based products. Here we demonstrate…
This work explores the use of computer vision for image segmentation and classification of medical fluid samples in transparent containers (for example, tubes, syringes, infusion bags). Handling fluids such as infusion fluids, blood, and…
Objective The concentration of bilirubin in blood or serum is useful for assessing liver function as well as monitoring treatment. This study evaluates the clinical performance of a novel point-of-care (PoC) device for the detection of…
In concentrated macromolecular dispersions, far-from-ideal intermolecular interactions determine the dispersion behaviors including phase transition, crystallization, and liquid-liquid phase separation. Here, we present a novel versatile…
Purpose: Hemolysis is a key issue in the design of blood-handling medical devices. Computational prediction of this phenomenon is challenging due to the complex multiscale nature of blood. As a result, conventional approaches often fail to…
Elevated stress negatively impacts health, increasing the risk of cardiovascular diseases, weak immunity, anxiety, and cognitive decline. Current lab-based methods lack real-time stress measurement, while saliva diagnostics offers a…
Background: Computational fluid dynamics (CFD) has become an essential design tool for ventricular assist devices (VADs), where the goal of maximizing performance often conflicts with biocompatibility. This tradeoff becomes even more…