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Fine-tuning large pre-trained vision foundation models in a parameter-efficient manner is critical for downstream vision tasks, considering the practical constraints of computational and storage costs. Low-rank adaptation (LoRA) is a…

计算机视觉与模式识别 · 计算机科学 2025-03-25 Houqiang Zhong , Shaocheng Shen , Ke Cai , Zhenglong Wu , Jiangchao Yao , Yuan Cheng , Xuefei Li , Xiaoyun Zhang , Li Song , Qiang Hu

Low-Rank Adaptation (LoRA) is an efficient fine-tuning method that has been extensively applied in areas such as natural language processing and computer vision. Existing LoRA fine-tuning approaches excel in static environments but struggle…

机器学习 · 计算机科学 2025-02-26 Xin Zhang , Liang Bai , Xian Yang , Jiye Liang

Despite recent advancements in the field of medical image analysis with the use of pretrained foundation models, the issue of distribution shifts between cross-source images largely remains adamant. To circumvent that issue, investigators…

计算机视觉与模式识别 · 计算机科学 2026-04-14 Sanjaya Poudel , Nikita Kunwor , Raj Simkhada , Mustafa Munir , Manish Dhakal , Khem Poudel

LoRA is a technique that reduces the number of trainable parameters in a neural network by introducing low-rank adapters to linear layers. This technique is used both for fine-tuning and full training of large language models. This paper…

机器学习 · 计算机科学 2024-06-17 Daria Cherniuk , Aleksandr Mikhalev , Ivan Oseledets

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

机器学习 · 计算机科学 2019-10-17 Tristan Bepler , Bonnie Berger

Low-rank adaptation (LoRA) is a popular method for fine-tuning large-scale pre-trained models in downstream tasks by learning low-rank incremental matrices. Though LoRA and its variants effectively reduce the number of trainable parameters…

机器学习 · 计算机科学 2024-03-21 Rushi Qiang , Ruiyi Zhang , Pengtao Xie

Despite their dominance in modern DL and, especially, NLP domains, transformer architectures exhibit sub-optimal performance on long-range tasks compared to recent layers that are specifically designed for this purpose. In this work,…

机器学习 · 计算机科学 2023-11-29 Itamar Zimerman , Lior Wolf

RNA, whose functionality is largely determined by its structure, plays an important role in many biological activities. The prediction of pairwise structural proximity between each nucleotide of an RNA sequence can characterize the…

定量方法 · 定量生物学 2024-01-22 Yiren Jian , Chongyang Gao , Chen Zeng , Yunjie Zhao , Soroush Vosoughi

In this paper, we introduce Symmetric Low-Rank Adapters, an optimized variant of LoRA with even fewer weights. This method utilizes Low-Rank Symmetric Weight Matrices to learn downstream tasks more efficiently. Traditional LoRA accumulates…

机器学习 · 计算机科学 2025-04-17 Tales Panoutsos , Rodrygo L. T. Santos , Flavio Figueiredo

Parameter-efficient fine-tuning enables fast personalization of text-to-image diffusion models, but composing multiple custom concepts remains challenging due to representation interference. Existing modular methods either rely on expensive…

机器学习 · 计算机科学 2026-05-22 Javad Parsa , Enis Simsar , Amir Joudaki , Thomas Hofmann , André M. H. Teixeira

Genetic algorithms have played an important role in engineering optimization. Traditional GAs treat each gene separately. However, biophysical studies of gene regulatory networks revealed direct associations between different genes. It…

神经与进化计算 · 计算机科学 2024-05-01 Zhaoning Shi , Meng Xiang , Zhaoyang Hai , Xiabi Liu , Yan Pei

The kinetic folding of RNA sequences into secondary structures is modeled as a complex adaptive system, the components of which are possible RNA structural rearrangements (SRs) and their associated bases and base pairs. RNA bases and base…

生物大分子 · 定量生物学 2007-05-23 Wilfred Ndifon

Predicting the secondary structure of RNA is a core challenge in computational biology, essential for understanding molecular function and designing novel therapeutics. The field has evolved from foundational but accuracy-limited…

生物大分子 · 定量生物学 2026-05-20 Giuseppe Sacco , Giovanni Bussi , Guido Sanguinetti

Deep Learning and big data have shown tremendous success in bioinformatics and computational biology in recent years; artificial intelligence methods have also significantly contributed in the task of protein function classification. This…

生物大分子 · 定量生物学 2022-11-18 Divyanshu Aggarwal , Yasha Hasija

While orthogonal subspace methods try to mitigate task interference in Continual Learning (CL), they often suffer from energy diffusion across the basis, hindering knowledge compaction and exhausting capacity for future tasks. We observe…

机器学习 · 计算机科学 2026-05-28 Longhua Li , Lei Qi , Qi Tian , Xin Geng

Fine-tuning is the primary methodology for tailoring pre-trained large language models to specific tasks. As the model's scale and the diversity of tasks expand, parameter-efficient fine-tuning methods are of paramount importance. One of…

机器学习 · 计算机科学 2024-01-10 Wenhan Xia , Chengwei Qin , Elad Hazan

Foundation models, now powering most of the exciting applications in deep learning, are almost universally based on the Transformer architecture and its core attention module. Many subquadratic-time architectures such as linear attention,…

机器学习 · 计算机科学 2024-06-03 Albert Gu , Tri Dao

Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from…

A novel sequence architecture is introduced, Versor, which uses Conformal Geometric Algebra (CGA) in place of traditional linear operations to achieve structural generalization and significant performance improvements on a variety of tasks,…

机器学习 · 计算机科学 2026-02-27 Truong Minh Huy , Edward Hirst

Parameter-Efficient Fine-Tuning (PEFT) has become an essential approach for adapting large-scale pre-trained models while reducing computational costs. Among PEFT methods, LoRA significantly reduces trainable parameters by decomposing…

计算与语言 · 计算机科学 2025-03-31 Jiancheng Zhao , Xingda Yu , Zhen Yang