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Time series with long-term structure arise in a variety of contexts and capturing this temporal structure is a critical challenge in time series analysis for both inference and forecasting settings. Traditionally, state space models have…

机器学习 · 统计学 2020-06-12 Anna K. Yanchenko , Sayan Mukherjee

Low-Rank Adaptation (LoRA) is widely adopted for downstream fine-tuning of foundation models due to its efficiency and zero additional inference cost. Many real-world applications require foundation models to specialize in several specific…

机器学习 · 计算机科学 2025-09-30 Jian Liang , Wenke Huang , Xianda Guo , Guancheng Wan , Bo Du , Mang Ye

Fine-tuning has proven to be highly effective in adapting pre-trained models to perform better on new desired tasks with minimal data samples. Among the most widely used approaches are reparameterization methods, which update a target…

机器学习 · 计算机科学 2025-10-27 Aymane El Firdoussi , El Mahdi Chayti , Mohamed El Amine Seddik , Martin Jaggi

Parameter-efficient fine-tuning (PEFT) techniques such as low-rank adaptation (LoRA) can effectively adapt large pre-trained foundation models to downstream tasks using only a small fraction (0.1%-10%) of the original trainable weights. An…

计算机视觉与模式识别 · 计算机科学 2026-01-01 Samar Khanna , Medhanie Irgau , David B. Lobell , Stefano Ermon

Despite large neural networks demonstrating remarkable abilities to complete different tasks, they require excessive memory usage to store the optimization states for training. To alleviate this, the low-rank adaptation (LoRA) is proposed…

机器学习 · 计算机科学 2024-06-14 Yongchang Hao , Yanshuai Cao , Lili Mou

We present techniques for speeding up the test-time evaluation of large convolutional networks, designed for object recognition tasks. These models deliver impressive accuracy but each image evaluation requires millions of floating point…

计算机视觉与模式识别 · 计算机科学 2024-03-15 Remi Denton , Wojciech Zaremba , Joan Bruna , Yann LeCun , Rob Fergus

Low-Rank Adaptation (LoRA) has emerged as one of the most widely used parameter-efficient fine-tuning (PEFT) methods for adapting large language models (LLMs) to downstream tasks. While highly effective in single-task settings, it struggles…

计算与语言 · 计算机科学 2025-10-14 Bo Cheng , Xu Wang , Jinda Liu , Yi Chang , Yuan Wu

Topological data analysis (TDA) detects geometric structure in biological data. However, many TDA algorithms are memory intensive and impractical for massive datasets. Here, we introduce a statistical protocol that reduces TDA's memory…

定量方法 · 定量生物学 2025-09-05 Andrew J. Stier , Naichen Shi , Raed Al Kontar , Chad Giusti , Marc G. Berman

There has been a significant increase in the deployment of neural network models, presenting substantial challenges in model adaptation and fine-tuning. Efficient adaptation is crucial in maintaining model performance across diverse tasks…

机器学习 · 计算机科学 2025-04-02 Maolin Wang , Xiangyu Zhao

Scaling up model depth and size is now a common approach to raise accuracy in many deep learning (DL) applications, as evidenced by the widespread success of multi-billion or even trillion parameter models in natural language processing…

分布式、并行与集群计算 · 计算机科学 2022-08-05 Kabir Nagrecha , Arun Kumar

Modern Transformer-based models frequently suffer from miscalibration, producing overconfident predictions that do not reflect true empirical frequencies. This work investigates the calibration dynamics of LoRA: Low-Rank Adaptation and a…

计算与语言 · 计算机科学 2026-03-31 Bartosz Trojan , Filip Gębala

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet,…

定量方法 · 定量生物学 2023-04-10 Mingchen Li , Liqi Kang , Yi Xiong , Yu Guang Wang , Guisheng Fan , Pan Tan , Liang Hong

This letter introduces ERRA, an embodied learning architecture that enables robots to jointly obtain three fundamental capabilities (reasoning, planning, and interaction) for solving long-horizon language-conditioned manipulation tasks.…

机器人学 · 计算机科学 2023-04-06 Chao Zhao , Shuai Yuan , Chunli Jiang , Junhao Cai , Hongyu Yu , Michael Yu Wang , Qifeng Chen

In this work we introduce RITA: a suite of autoregressive generative models for protein sequences, with up to 1.2 billion parameters, trained on over 280 million protein sequences belonging to the UniRef-100 database. Such generative models…

定量方法 · 定量生物学 2022-07-18 Daniel Hesslow , Niccoló Zanichelli , Pascal Notin , Iacopo Poli , Debora Marks

In this paper, we propose an end-to-end deep learning model, called E2Efold, for RNA secondary structure prediction which can effectively take into account the inherent constraints in the problem. The key idea of E2Efold is to directly…

机器学习 · 计算机科学 2020-06-11 Xinshi Chen , Yu Li , Ramzan Umarov , Xin Gao , Le Song

Many real-world systems studied are governed by complex, nonlinear dynamics. By modeling these dynamics, we can gain insight into how these systems work, make predictions about how they will behave, and develop strategies for controlling…

机器学习 · 统计学 2019-06-05 Josue Nassar , Scott W. Linderman , Monica Bugallo , Il Memming Park

Low-rank adaptation (LoRA) has been widely adopted as a parameter-efficient technique for fine-tuning large-scale pre-trained models. However, it still lags behind full fine-tuning in performance, partly due to its insufficient exploitation…

机器学习 · 计算机科学 2026-04-03 Zhizhong Li , Sina Sajadmanesh , Jingtao Li , Lingjuan Lyu

Pre-training Large Language Models (LLMs) on web-scale datasets becomes fundamental for advancing general-purpose AI. In contrast, enhancing their predictive performance on downstream tasks typically involves adapting their knowledge…

Deep Learning's recent successes have mostly relied on Convolutional Networks, which exploit fundamental statistical properties of images, sounds and video data: the local stationarity and multi-scale compositional structure, that allows…

机器学习 · 计算机科学 2015-06-18 Mikael Henaff , Joan Bruna , Yann LeCun

Background: Small interfering RNA (siRNA) is a promising therapeutic agent due to its ability to silence disease-related genes via RNA interference. While traditional machine learning and early deep learning methods have made progress in…

生物大分子 · 定量生物学 2025-03-07 Wangdan Liao , Weidong Wang