相关论文: TopoLa: A Universal Framework to Enhance Cell Repr…

Topological data analysis (TDA) detects geometric structure in biological data. However, many TDA algorithms are memory intensive and impractical for massive datasets. Here, we introduce a statistical protocol that reduces TDA's memory…

This paper proposes a concise coding of the cells of n-dimensional finite regular grids. It induces a simple, generic and efficient framework for implementing classical digital topology data structures and algorithms. Discrete subsets of…

In digital pathology, the spatial context of cells is important for cell classification, cancer diagnosis and prognosis. To model such complex cell context, however, is challenging. Cells form different mixtures, lineages, clusters and…

In machine learning, data is usually represented in a (flat) Euclidean space where distances between points are along straight lines. Researchers have recently considered more exotic (non-Euclidean) Riemannian manifolds such as hyperbolic…

In a world abundant with diverse data arising from complex acquisition techniques, there is a growing need for new data analysis methods. In this paper we focus on high-dimensional data that are organized into several hierarchical datasets.…

Learning unbiased node representations for imbalanced samples in the graph has become a more remarkable and important topic. For the graph, a significant challenge is that the topological properties of the nodes (e.g., locations, roles) are…

Methods allowing the synthesis of realistic cell shapes could help generate training data sets to improve cell tracking and segmentation in biomedical images. Deep generative models for cell shape synthesis require a light-weight and…

Topological Data Analysis (TDA) can be used to detect and characterize holes in an image, such as zero-dimensional holes (connected components) or one-dimensional holes (loops). However, there is currently no widely accepted statistical…

A long-standing challenge is designing multi-scale structures with good connectivity between cells while optimizing each cell to reach close to the theoretical performance limit. We propose a new method for direct multi-scale topology…

Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological assessment as well as localized readouts that can be aligned…

In this study, we present and analyze a framework for geometric and topological estimation for mapping of unknown environments. We consider agents mimicking motion behaviors of cyborg insects, known as biobots, and exploit coordinate-free…

Hyperbolic space is quickly gaining traction as a promising geometry for hierarchical and robust representation learning. A core open challenge is the development of a mathematical formulation of hyperbolic neural networks that is both…

Topological data analysis (TDA) uses persistent homology to quantify loops and higher-dimensional holes in data, making it particularly relevant for examining the characteristics of images of cells in the field of cell biology. In the…

Topological data analysis (TDA) is a branch of computational mathematics, bridging algebraic topology and data science, that provides compact, noise-robust representations of complex structures. Deep neural networks (DNNs) learn millions of…

One of the key challenges in many research fields is uncovering how different interconnected systems interact within complex networks, typically represented as multi-layer networks. Capturing the intra- and cross-layer interactions among…

We present a multi-level geocoding model (MLG) that learns to associate texts to geographic locations. The Earth's surface is represented using space-filling curves that decompose the sphere into a hierarchy of similarly sized,…

Single-cell RNA sequencing (scRNA-seq) enables dissecting cellular heterogeneity in tissues, resulting in numerous biological discoveries. Various computational methods have been devised to delineate cell types by clustering scRNA-seq data…

Spatial graphs provide a lightweight and elegant representation of curvilinear anatomical structures such as blood vessels, lung airways, and neuronal networks. Accurately modeling these graphs is crucial in clinical and (bio-)medical…

Generative models, such as GANs and diffusion models, have been used to augment training sets and boost performances in different tasks. We focus on generative models for cell detection instead, i.e., locating and classifying cells in given…

Taxonomies are valuable resources for many applications, but the limited coverage due to the expensive manual curation process hinders their general applicability. Prior works attempt to automatically expand existing taxonomies to improve…