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A key goal of bioinformatics is to create database systems and software platforms capable of storing and analysing large sets of biological data. Hundreds of biological databases are now available and provide access to huge amount of…

We introduce BioTrove, the largest publicly accessible dataset designed to advance AI applications in biodiversity. Curated from the iNaturalist platform and vetted to include only research-grade data, BioTrove contains 161.9 million…

Virus infection is one of the major diseases that seriously threaten human health. To meet the growing demand for mining and sharing data resources related to antiviral drugs and to accelerate the design and discovery of new antiviral…

生物大分子 · 定量生物学 2022-09-28 Shunming Tao , Yihao Chen , Jingxing Wu , Duancheng Zhao , Hanxuan Cai , Ling Wang

Over the past decade there has been a significant growth in bioinformatics databases, tools and resources. Although, bioinformatics is becoming more specific, increasing the number of bioinformatics-wares has made it difficult for…

We present BEAST DB, an open-source database comprised of ab initio electrochemical data computed using grand-canonical density functional theory in implicit solvent at consistent calculation parameters. The database contains over 20,000…

Cancer Biotherapy (CB), as opposed to cancer chemotherapy, is the use of macromolecular, biological agents instead of organic chemicals or drugs to treat cancer. Biological agents usually have higher selectivity and have less toxic side…

生物大分子 · 定量生物学 2016-02-29 Preety Priya , Vicente M. Reyes

Biologists are increasingly using databases for storing and managing their data. Biological databases typically consist of a mixture of raw data, metadata, sequences, annotations, and related data obtained from various sources. Current…

数据库 · 计算机科学 2007-05-23 Mohamed Y. Eltabakh , Mourad Ouzzani , Walid G. Aref

Tattoos have been used effectively as soft biometrics to assist law enforcement in the identification of offenders and victims, as they contain discriminative information, and are a useful indicator to locate members of a criminal gang or…

计算机视觉与模式识别 · 计算机科学 2024-05-14 Lazaro Janier Gonzalez-Soler , Maciej Salwowski , Christian Rathgeb , Daniel Fischer

Research resources (RRs) such as data, software, and tools are essential pillars of scientific research. The field of biomedicine, a critical scientific discipline, is witnessing a surge in research publications resulting in the…

数字图书馆 · 计算机科学 2024-09-24 Li Zhang , Mengting Sun , Chong Jiang , Haihua Chen

Biobanks advance biomedical and clinical research by collecting and offering data and biological samples for numerous studies. However, the impact of these repositories varies greatly due to differences in their purpose, scope, governance,…

With high-throughput biotechnologies generating unprecedented quantities of data, researchers are faced with the challenge of locating and comparing an exponentially growing number of programs and websites dedicated to computational…

Existing toxic detection models face significant limitations, such as lack of transparency, customization, and reproducibility. These challenges stem from the closed-source nature of their training data and the paucity of explanations for…

计算与语言 · 计算机科学 2025-01-24 Tinh Son Luong , Thanh-Thien Le , Thang Viet Doan , Linh Ngo Van , Thien Huu Nguyen , Diep Thi-Ngoc Nguyen

Biomedical researchers increasingly rely on large-scale structured databases for complex analytical tasks. However, current text-to-SQL systems often struggle to map qualitative scientific questions into executable SQL, particularly when…

Protein-protein interactions (PPIs) perform important roles on biological functions. Researches of mutants on protein interactions can further understand PPIs. In the past, many researchers have developed databases that stored mutants on…

生物大分子 · 定量生物学 2017-08-08 Quanya Liu , Peng Chen , Bing Wang , Jinyan Li

The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases. Here we introduce a new phenotypic database summarizing…

生物物理 · 物理学 2015-05-14 Cesar A. Hidalgo , Nicholas Blumm , Albert-Laszlo Barabasi , Nicholas Christakis

We train a neural network to predict chemical toxicity based on gene expression data. The input to the network is a full expression profile collected either in vitro from cultured cells or in vivo from live animals. The output is a set of…

基因组学 · 定量生物学 2019-02-04 Peter Eastman , Vijay S. Pande

Timely and accurate extraction of Adverse Drug Events (ADE) from biomedical literature is paramount for public safety, but involves slow and costly manual labor. We set out to improve drug safety monitoring (pharmacovigilance, PV) through…

Successful biomedical relation extraction can provide evidence to researchers and clinicians about possible unknown associations between biomedical entities, advancing the current knowledge we have about those entities and their inherent…

信息检索 · 计算机科学 2020-04-22 Diana Sousa , Francisco M. Couto

There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell…

定量方法 · 定量生物学 2020-02-26 Finn Kuusisto , Vitor Santos Costa , Zhonggang Hou , James Thomson , David Page , Ron Stewart

Therapeutics machine learning is an emerging field with incredible opportunities for innovatiaon and impact. However, advancement in this field requires formulation of meaningful learning tasks and careful curation of datasets. Here, we…

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