相关论文: From modelling to understanding: the signals in ne…
The in silico simulations are widely used in contemporary systems biology including the analysis of nerve pulse propagation. As known from numerous experiments, the propagation of an action potential is accompanied by mechanical and thermal…
Recent studies have revealed the complex structure of nerve signals in axons. There is experimental evidence that the propagation of an electrical signal (action potential) is accompanied by mechanical and thermal effects. In this paper,…
The recent theoretical and experimental studies have revealed many details of signal propagation in nervous systems. In this paper an attempt is made to unify various mathematical models which describe the signal propagation in nerve…
This paper deals with the mathematical modelling of signal propagation in nerve fibres. Due to the complexity of the processes where electrical, mechanical, and thermal effects are coupled, a phenomenological approach helps to build…
In this paper mathematical models are formulated in order to simulate heat production and corresponding temperature changes which accompany the propagation of an axon potential. Based on earlier experimental results, several models are…
Mathematical models describing the signals propagating in nerve fibres are described. The emphasis is on the mathematical structures of governing equations while the extremely rich physiological aspects are here not analysed. Based on…
Recent studies have revealed the complex structure of nerve signals in axons. Besides the electrical signal, mechanical and thermal effects are also detected in many experimental studies. In this paper, the mathematical models of heat…
We investigate different mechanical effects which accompany the nerve pulse propagation by using mathematical modeling. The propagation process is composed by three connected phenomena: (i) the action potential (electrical signal) which is…
The propagation of an action potential is accompanied by mechanical and thermal effects. Several mathematical models explain the deformation of the unmyelinated axon wall. In this paper, the deformation of the myelinated axon wall is…
In this work, we propose and study the stability of nerve impulse propagation as electrical and mechanical signals through linear approximation. We present a potential energy stored in the biomembrane due to the deformation, bending, and…
The accepted model for nerve pulse propagation in biological membranes seems insufficient. It is restricted to dissipative electrical phenomena and considers nerve pulses exclusively as a microscopic phenomenon. A simple thermodynamic model…
The action potential propagating in a nerve fibre generates accompanying mechanical and thermal effects. The whole signal is therefore an ensemble which includes primary and secondary components. The primary components of a signal are the…
Models that invoke nonlinear wavefront propagation in a chemically excitable medium are rife in the biological literature. Indeed, the idea that wavefront propagation can serve as a signaling mechanism has often been invoked to explain…
In the last fifteen years a debate emerged about the validity of the famous Hodgkin-Huxley model for nerve impulse. Mechanical models have been proposed. This note reviews the experimental properties of the nerve impulse and discusses the…
We propose a neural network model of multi-neuron interacting system that simulates neurons to interact each other through the surroundings of neuronal cell bodies. We physically model the neuronal cell surroundings, include the dendrites,…
This work proposes a two-dimensional electrophysiological model for describing neuronal responses to external electric stimuli under patch-clamped conditions. Our proposed model successfully captures the key features of the Hodgkin-Huxley…
A quantitative description of pulses and wave trains in the spatially discrete Hodgkin-Huxley model for myelinated nerves is given. Predictions of the shape and speed of the waves and the thresholds for propagation failure are obtained. Our…
Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential…
Objective: Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at the…
Many physical systems--from mechanical lattices and electrical circuits to biological tissues and architected metamaterials--can be understood as networks transmitting physical quantities. We present a unified mathematical framework for…