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The increasing availability of experimental data has intensified interest in calibrating stochastic models, raising fundamental questions about parameter identifiability. Structural identifiability determines whether parameters can be…

统计方法学 · 统计学 2026-05-14 Arianna Ceccarelli , Alexander P. Browning , Ruth E. Baker

Stochasticity plays a key role in many biological systems, necessitating the calibration of stochastic mathematical models to interpret associated data. For model parameters to be estimated reliably, it is typically the case that they must…

统计方法学 · 统计学 2025-12-11 Alexander P Browning , Michael J Chappell , Hamid Rahkooy , Torkel E Loman , Ruth E Baker

A key step in mechanistic modelling of dynamical systems is to conduct a structural identifiability analysis. This entails deducing which parameter combinations can be estimated from a given set of observed outputs. The standard…

最优化与控制 · 数学 2026-03-30 Johannes G Borgqvist , Alexander P Browning , Fredrik Ohlsson , Ruth E Baker

Effective application of mathematical models to interpret biological data and make accurate predictions often requires that model parameters are identifiable. Approaches to assess the so-called structural identifiability of models are…

定量方法 · 定量生物学 2024-02-28 Alexander P Browning , Maria Tască , Carles Falcó , Ruth E Baker

We discuss issues of structural and practical identifiability of partially observed differential equations which are often applied in systems biology. The development of mathematical methods to investigate structural non-identifiability has…

统计方法学 · 统计学 2021-04-20 Franz-Georg Wieland , Adrian L. Hauber , Marcus Rosenblatt , Christian Tönsing , Jens Timmer

Computational and mathematical models rely heavily on estimated parameter values for model development. Identifiability analysis determines how well the parameters of a model can be estimated from experimental data. Identifiability analysis…

定量方法 · 定量生物学 2021-02-12 Marissa Renardy , Denise Kirschner , Marisa Eisenberg

Identifiability of parameters is a fundamental prerequisite for model identification. It concerns uniqueness of the model parameters determined from experimental or simulated observations. This dissertation specifically deals with…

经济学 · 定量金融 2016-02-04 Di Molfetta Giuseppe

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

定量方法 · 定量生物学 2018-12-12 Alejandro F. Villaverde

Structural parameter identifiability is a property of a differential model with parameters that allows for the parameters to be determined from the model equations in the absence of noise. One of the standard approaches to assessing this…

代数几何 · 数学 2020-12-29 Alexey Ovchinnikov , Gleb Pogudin , Peter Thompson

Linear causal models are important tools for modeling causal dependencies and yet in practice, only a subset of the variables can be observed. In this paper, we examine the parameter identifiability of these models by investigating whether…

机器学习 · 计算机科学 2025-02-11 Xinshuai Dong , Ignavier Ng , Biwei Huang , Yuewen Sun , Songyao Jin , Roberto Legaspi , Peter Spirtes , Kun Zhang

We developed a novel approach to identification and model testing in linear structural equation models (SEMs) based on auxiliary variables (AVs), which generalizes a widely-used family of methods known as instrumental variables. The…

统计方法学 · 统计学 2019-10-09 Bryant Chen , Daniel Kumor , Elias Bareinboim

Data-driven modeling of dynamical systems often faces numerous data-related challenges. A fundamental requirement is the existence of a unique set of parameters for a chosen model structure, an issue commonly referred to as identifiability.…

系统与控制 · 电气工程与系统科学 2024-05-24 Arthur N. Montanari , François Lamoline , Robert Bereza , Jorge Gonçalves

The successful application of modern machine learning for time series classification is often hampered by limitations in quality and quantity of available training data. To overcome these limitations, available domain expert knowledge in…

机器学习 · 计算机科学 2025-02-07 Janis Norden , Elisa Oostwal , Michael Chappell , Peter Tino , Kerstin Bunte

Learning the unknown causal parameters of a linear structural causal model is a fundamental task in causal analysis. The task, known as the problem of identification, asks to estimate the parameters of the model from a combination of…

人工智能 · 计算机科学 2024-07-18 Julian Dörfler , Benito van der Zander , Markus Bläser , Maciej Liskiewicz

Differential equation models are crucial to scientific processes. The values of model parameters are important for analyzing the behaviour of solutions. A parameter is called globally identifiable if its value can be uniquely determined…

定量方法 · 定量生物学 2024-02-07 Helen Byrne , Heather Harrington , Alexey Ovchinnikov , Gleb Pogudin , Hamid Rahkooy , Pedro Soto

Parameter identification problems for partial differential equations are an important subclass of inverse problems. The parameter-to-state map, which maps the parameter of interest to the respective solution of the PDE or state of the…

数值分析 · 数学 2020-02-13 Heiko Hoffmann , Anne Wald

Elimination of unknowns in a system of differential equations is often required when analysing (possibly nonlinear) dynamical systems models, where only a subset of variables are observable. One such analysis, identifiability, often relies…

代数几何 · 数学 2022-11-28 Ruiwen Dong , Christian Goodbrake , Heather A Harrington , Gleb Pogudin

Structural monitoring for complex built environments often suffers from mismatch between design, laboratory testing, and actual built parameters. Additionally, real-world structural identification problems encounter many challenges. For…

机器学习 · 计算机科学 2022-08-29 Xuyang Li , Hamed Bolandi , Talal Salem , Nizar Lajnef , Vishnu Naresh Boddeti

The successful application of epidemic models hinges on our ability to estimate model parameters from limited observations reliably. An often-overlooked step before estimating model parameters consists of ensuring that the model parameters…

定量方法 · 定量生物学 2023-09-29 Gerardo Chowell , Sushma Dahal , Yuganthi R. Liyanage , Amna Tariq , Necibe Tuncer

This paper studies the numerical analysis of a parameter identification problem governed by elliptic equations with power-type nonlinearity. We propose a numerical reconstruction via a suitable least-squares minimization problem based on…

数值分析 · 数学 2026-03-10 De-Han Chen , Yi-Hsuan Lin , Irwin Yousept
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