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Learning causal relationships between pairs of complex traits from observational studies is of great interest across various scientific domains. However, most existing methods assume the absence of unmeasured confounding and restrict causal…

统计方法学 · 统计学 2024-07-17 Wei Li , Rui Duan , Sai Li

A common assumption in causal inference from observational data is that there is no hidden confounding. Yet it is, in general, impossible to verify this assumption from a single dataset. Under the assumption of independent causal mechanisms…

统计方法学 · 统计学 2023-11-07 Rickard K. A. Karlsson , Jesse H. Krijthe

With the extensive use of digital devices, online experimental platforms are commonly used to conduct experiments to collect data for evaluating different variations of products, algorithms, and interface designs, a.k.a., A/B tests. In…

统计方法学 · 统计学 2024-07-09 Qiong Zhang , Lulu Kang , Xinwei Deng

We propose a fully probabilistic formulation of the notion of mechanistic interaction (interaction in some fundamental mechanistic sense) between the effects of putative (possibly continuous) causal factors A and B on a binary outcome…

统计方法学 · 统计学 2020-04-28 Carlo Berzuini , A. Philip Dawid

The possibility to understand and to quantitatively model the physics of the interactions between pedestrians walking in crowds has compelling relevant applications, e.g. related to the design and safety of civil infrastructures. In this…

物理与社会 · 物理学 2018-12-19 Alessandro Corbetta , Jasper Meeusen , Chung-min Lee , Roberto Benzi , Federico Toschi

Assessing image quality is crucial in image processing tasks such as compression, super-resolution, and denoising. While subjective assessments involving human evaluators provide the most accurate quality scores, they are impractical for…

多媒体 · 计算机科学 2025-03-26 Shima Mohammadi , João Ascenso

Subjective assessment tests are often employed to evaluate image processing systems, notably image and video compression, super-resolution among others and have been used as an indisputable way to provide evidence of the performance of an…

多媒体 · 计算机科学 2023-11-13 Shima Mohammadi , Joao Ascenso

Quantifying the complexity of systems consisting of many interacting parts has been an important challenge in the field of complex systems in both abstract and applied contexts. One approach, the complexity profile, is a measure of the…

斑图形成与孤子 · 物理学 2013-06-03 Yavni Bar-Yam , Dion Harmon , Yaneer Bar-Yam

We consider stochastic systems of interacting particles or agents, with dynamics determined by an interaction kernel which only depends on pairwise distances. We study the problem of inferring this interaction kernel from observations of…

统计理论 · 数学 2020-07-31 Fei Lu , Mauro Maggioni , Sui Tang

A major challenge in estimating treatment effects in observational studies is the reliance on untestable conditions such as the assumption of no unmeasured confounding. In this work, we propose an algorithm that can falsify the assumption…

统计方法学 · 统计学 2025-06-03 Rickard K. A. Karlsson , Jesse H. Krijthe

Pairwise models like the Ising model or the generalized Potts model have found many successful applications in fields like physics, biology, and economics. Closely connected is the problem of inverse statistical mechanics, where the goal is…

无序系统与神经网络 · 物理学 2022-01-12 Christoph Feinauer , Carlo Lucibello

Ising models with pairwise interactions are the least structured, or maximum-entropy, probability distributions that exactly reproduce measured pairwise correlations between spins. Here we use this equivalence to construct Ising models that…

神经元与认知 · 定量生物学 2007-05-23 Gasper Tkacik , Elad Schneidman , Michael J Berry , William Bialek

Estimating causal effects from observational data is not always possible due to confounding. Identifying a set of appropriate covariates (adjustment set) and adjusting for their influence can remove confounding bias; however, such a set is…

统计方法学 · 统计学 2020-11-19 Sofia Triantafillou , Gregory Cooper

Several types of biological networks have recently been shown to be accurately described by a maximum entropy model with pairwise interactions, also known as the Ising model. Here we present an approach for finding the optimal mappings…

生物物理 · 物理学 2015-05-14 Jeffrey D. Fitzgerald , Tatyana O. Sharpee

One of the most common pitfalls often found in high dimensional biological data sets are correlations between the features. This may lead to statistical and machine learning methodologies overvaluing or undervaluing these correlated…

We propose a procedure for sparse regression with pairwise interactions, by generalizing the Univariate Guided Sparse Regression (UniLasso) methodology. A central contribution is our introduction of a concept of univariate (or marginal)…

统计方法学 · 统计学 2026-01-05 Aymen Echarghaoui , Robert Tibshirani

Analysing correlations between streams of events is an important problem. It arises for example in Neurosciences, when the connectivity of neurons should be inferred from spike trains that record neurons' individual spiking activity. While…

神经元与认知 · 定量生物学 2021-08-11 Krempl , Georg , Kottke , Daniel , Pham Minh , Tuan

We propose a new experiment employing two independent sources of spin correlated photon pairs. Two photons from different unpolarized sources each pass through a polarizer to a detector. Although their trajectories never mix or cross they…

量子物理 · 物理学 2010-08-05 Mladen Pavicic , Johann Summhammer

Tipping points are critical thresholds of parameters where tiny perturbations can lead to abrupt and large qualitative changes in the systems. Many real-world systems that exhibit tipping behavior can be represented as networks of…

混沌动力学 · 物理学 2025-09-10 Richita Ghosh , Manish Dev Shrimali

We address the common yet often-overlooked selection bias in interventional studies, where subjects are selectively enrolled into experiments. For instance, participants in a drug trial are usually patients of the relevant disease; A/B…

机器学习 · 计算机科学 2025-03-11 Haoyue Dai , Ignavier Ng , Jianle Sun , Zeyu Tang , Gongxu Luo , Xinshuai Dong , Peter Spirtes , Kun Zhang