相关论文: scGHSOM: Hierarchical clustering and visualization…

Cluster analysis of biological samples using gene expression measurements is a common task which aids the discovery of heterogeneous biological sub-populations having distinct mRNA profiles. Several model-based clustering algorithms have…

We present a new approach for the analysis of genome-wide expression data. Our method is designed to overcome the limitations of traditional techniques, when applied to large-scale data. Rather than alloting each gene to a single cluster,…

We present a new technique for visualizing high-dimensional data called cluster MDS (cl-MDS), which addresses a common difficulty of dimensionality reduction methods: preserving both local and global structures of the original sample in a…

We here present SIMLR (Single-cell Interpretation via Multi-kernel LeaRning), an open-source tool that implements a novel framework to learn a sample-to-sample similarity measure from expression data observed for heterogenous samples. SIMLR…

Understanding the response of an output variable to multi-dimensional inputs lies at the heart of many data exploration endeavours. Topology-based methods, in particular Morse theory and persistent homology, provide a useful framework for…

The scalability of a particular visualization approach is limited by the ability for people to discern differences between plots made with different datasets. Ideally, when the data changes, the visualization changes in perceptible ways.…

Image feature classification is a challenging problem in many computer vision applications, specifically, in the fields of remote sensing, image analysis and pattern recognition. In this paper, a novel Self Organizing Map, termed improved…

One of the main challenges for hierarchical clustering is how to appropriately identify the representative points in the lower level of the cluster tree, which are going to be utilized as the roots in the higher level of the cluster tree…

We present an unsupervised data processing workflow that is specifically designed to obtain a fast conformational clustering of long molecular dynamics simulation trajectories. In this approach we combine two dimensionality reduction…

Sustainable water quality underpins ecological balance and water security. Assessing and managing lakes and reservoirs is difficult due to data sparsity, heterogeneity, and nonlinear relationships among parameters. This review examines how…

Feature selection is an important and challenging task in high dimensional clustering. For example, in genomics, there may only be a small number of genes that are differentially expressed, which are informative to the overall clustering…

In several application domains, high-dimensional observations are collected and then analysed in search for naturally occurring data clusters which might provide further insights about the nature of the problem. In this paper we describe a…

We introduce a multidimensional, neural-network approach to reveal and measure urban segregation phenomena, based on the Self-Organizing Map algorithm (SOM). The multidimensionality of SOM allows one to apprehend a large number of variables…

Very-high-resolution (VHR) remote sensing (RS) image change detection (CD) has been a challenging task for its very rich spatial information and sample imbalance problem. In this paper, we have proposed a hierarchical change guiding map…

We investigate a densely packed, non-random arrangement of forty-six chromosomes (46,XY) in human nuclei. Here, we model systems-level chromosomal crosstalk by unifying intrinsic parameters (chromosomal length and number of genes) across…

Multi-scale design has been considered in recent image super-resolution (SR) works to explore the hierarchical feature information. Existing multi-scale networks aim to build elaborate blocks or progressive architecture for restoration. In…

Motivated by the problem of identifying correlations between genes or features of two related biological systems, we propose a model of \emph{feature selection} in which only a subset of the predictors $X_t$ are dependent on the…

Spectral clustering is a celebrated algorithm that partitions objects based on pairwise similarity information. While this approach has been successfully applied to a variety of domains, it comes with limitations. The reason is that there…

A first step in exploring population structure in crop plants and other organisms is to define the number of subpopulations that exist for a given data set. The genetic marker data sets being generated have become increasingly large over…

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…