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Accurately predicting gene expression from histopathology images offers a scalable and non-invasive approach to molecular profiling, with significant implications for precision medicine and computational pathology. However, existing methods…

计算机视觉与模式识别 · 计算机科学 2025-12-09 Yaxuan Song , Jianan Fan , Hang Chang , Weidong Cai

Cancer remains one of the leading causes of mortality worldwide, necessitating accurate diagnosis and prognosis. Whole Slide Imaging (WSI) has become an integral part of clinical workflows with advancements in digital pathology. While…

图像与视频处理 · 电气工程与系统科学 2025-04-09 Ahmad Hussein , Mukesh Prasad , Ali Anaissi , Ali Braytee

Tumour heterogeneity in breast cancer poses challenges in predicting outcome and response to therapy. Spatial transcriptomics technologies may address these challenges, as they provide a wealth of information about gene expression at the…

图像与视频处理 · 电气工程与系统科学 2023-09-19 Md Mamunur Rahaman , Ewan K. A. Millar , Erik Meijering

Morphological attributes from histopathological images and molecular profiles from genomic data are important information to drive diagnosis, prognosis, and therapy of cancers. By integrating these heterogeneous but complementary data, many…

机器学习 · 计算机科学 2022-02-28 Kaiwen Tan , Weixian Huang , Xiaofeng Liu , Jinlong Hu , Shoubin Dong

Accurate segmentation of brain tumors from multi-modal Magnetic Resonance (MR) images is essential in brain tumor diagnosis and treatment. However, due to the existence of domain shifts among different modalities, the performance of…

计算机视觉与模式识别 · 计算机科学 2021-05-18 Kelei He , Wen Ji , Tao Zhou , Zhuoyuan Li , Jing Huo , Xin Zhang , Yang Gao , Dinggang Shen , Bing Zhang , Junfeng Zhang

We present a multi-head vision transformer approach for multi-label plant species prediction in vegetation plot images, addressing the PlantCLEF 2025 challenge. The task involves training models on single-species plant images while testing…

计算机视觉与模式识别 · 计算机科学 2025-08-15 Hanna Herasimchyk , Robin Labryga , Tomislav Prusina

Scene Graph Generation (SGG) provides basic language representation of visual scenes, requiring models to grasp complex and diverse semantics between objects. This complexity and diversity in SGG leads to underrepresentation, where parts of…

计算机视觉与模式识别 · 计算机科学 2025-04-30 Yuxuan Wang , Xiaoyuan Liu

Glioblastoma is a highly aggressive form of brain cancer characterized by rapid progression and poor prognosis. Despite advances in treatment, the underlying genetic mechanisms driving this aggressiveness remain poorly understood. In this…

定量方法 · 定量生物学 2025-05-20 Ahmad Berjaoui , Louis Roussel , Eduardo Hugo Sanchez , Elizabeth Cohen-Jonathan Moyal

Multimodal learning significantly benefits cancer survival prediction, especially the integration of pathological images and genomic data. Despite advantages of multimodal learning for cancer survival prediction, massive redundancy in…

计算机视觉与模式识别 · 计算机科学 2024-02-27 Yilan Zhang , Yingxue Xu , Jianqi Chen , Fengying Xie , Hao Chen

Understanding how small molecules perturb gene expression is essential for uncovering drug mechanisms, predicting off-target effects, and identifying repurposing opportunities. While prior deep learning frameworks have integrated multimodal…

机器学习 · 计算机科学 2026-01-01 Pascal Passigan , Kevin Zhu , Angelina Ning

Large annotated datasets are essential for training robust Computer-Aided Diagnosis (CAD) models for breast cancer detection or risk prediction. However, acquiring such datasets with fine-detailed annotation is both costly and…

计算机视觉与模式识别 · 计算机科学 2025-10-31 Shunjie-Fabian Zheng , Hyeonjun Lee , Thijs Kooi , Ali Diba

Gene panel selection aims to identify the most informative genomic biomarkers in label-free genomic datasets. Traditional approaches, which rely on domain expertise, embedded machine learning models, or heuristic-based iterative…

基因组学 · 定量生物学 2025-09-12 Meng Xiao , Weiliang Zhang , Xiaohan Huang , Hengshu Zhu , Min Wu , Xiaoli Li , Yuanchun Zhou

The recent development of high-throughput sequencing creates a large collection of multi-omics data, which enables researchers to better investigate cancer molecular profiles and cancer taxonomy based on molecular subtypes. Integrating…

基因组学 · 定量生物学 2024-01-25 Bingjun Li , Sheida Nabavi

This paper proposes a multi-label classification algorithm capable of continual learning by applying an Adaptive Resonance Theory (ART)-based clustering algorithm and the Bayesian approach for label probability computation. The ART-based…

机器学习 · 计算机科学 2024-10-04 Naoki Masuyama , Yusuke Nojima , Chu Kiong Loo , Hisao Ishibuchi

Cancer subtyping is crucial for understanding the nature of tumors and providing suitable therapy. However, existing labelling methods are medically controversial, and have driven the process of subtyping away from teaching signals.…

机器学习 · 计算机科学 2022-11-15 Zheng Chen , Lingwei Zhu , Ziwei Yang , Takashi Matsubara

Cancer survival prediction requires integrating pathological Whole Slide Images (WSIs) and genomic profiles, a challenging task due to the inherent heterogeneity and the complexity of modeling both inter- and intra-modality interactions.…

图像与视频处理 · 电气工程与系统科学 2025-07-08 Mingxin Liu , Chengfei Cai , Jun Li , Pengbo Xu , Jinze Li , Jiquan Ma , Jun Xu

In the relentless efforts in enhancing medical diagnostics, the integration of state-of-the-art machine learning methodologies has emerged as a promising research area. In molecular biology, there has been an explosion of data generated…

机器学习 · 计算机科学 2024-05-17 Ibrahim Al-Hurani , Abedalrhman Alkhateeb , Salama Ikki

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

图像与视频处理 · 电气工程与系统科学 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Multi-label image classification is the task of predicting a set of labels corresponding to objects, attributes or other entities present in an image. In this work we propose the Classification Transformer (C-Tran), a general framework for…

计算机视觉与模式识别 · 计算机科学 2020-12-01 Jack Lanchantin , Tianlu Wang , Vicente Ordonez , Yanjun Qi

Digitization techniques for biomedical images yield different visual patterns in radiological exams. These differences may hamper the use of data-driven approaches for inference over these images, such as Deep Neural Networks. Another…

计算机视觉与模式识别 · 计算机科学 2019-12-10 Hugo Oliveira , Edemir Ferreira , Jefersson A. dos Santos