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We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

The burgeoning discipline of computational pathology shows promise in harnessing whole slide images (WSIs) to quantify morphological heterogeneity and develop objective prognostic modes for human cancers. However, progress is impeded by the…

计算机视觉与模式识别 · 计算机科学 2025-10-20 Chao Tu , Kun Huang , Jie Zhang , Qianjin Feng , Yu Zhang , Zhenyuan Ning

The clinical integration of deep learning models for brain tumor diagnosis in neuro-oncology is severely constrained by limited expert-annotated MRI data and substantial inter-institutional domain shift arising from variations in scanners,…

计算机视觉与模式识别 · 计算机科学 2026-05-06 Sapna Sachan , Amulya Kumar Mahto , Prashant Wagambar Patil

Designing accurate deep learning models for molecular property prediction plays an increasingly essential role in drug and material discovery. Recently, due to the scarcity of labeled molecules, self-supervised learning methods for learning…

生物大分子 · 定量生物学 2022-06-08 Han Li , Dan Zhao , Jianyang Zeng

Survival analysis stands as a pivotal process in cancer treatment research, crucial for predicting patient survival rates accurately. Recent advancements in data collection techniques have paved the way for enhancing survival predictions by…

机器学习 · 计算机科学 2024-07-26 Linhao Qu , Dan Huang , Shaoting Zhang , Xiaosong Wang

Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

计算机视觉与模式识别 · 计算机科学 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Recent advances in Spatial Transcriptomics (ST) pair histology images with spatially resolved gene expression profiles, enabling predictions of gene expression across different tissue locations based on image patches. This opens up new…

计算机视觉与模式识别 · 计算机科学 2025-03-21 Aniruddha Ganguly , Debolina Chatterjee , Wentao Huang , Jie Zhang , Alisa Yurovsky , Travis Steele Johnson , Chao Chen

In digital pathology, whole slide images (WSIs) are widely used for applications such as cancer diagnosis and prognosis prediction. Visual transformer models have recently emerged as a promising method for encoding large regions of WSIs…

计算机视觉与模式识别 · 计算机科学 2023-04-18 Shuai Jiang , Liesbeth Hondelink , Arief A. Suriawinata , Saeed Hassanpour

This paper presents a novel approach to accurately classify the hallmarks of cancer, which is a crucial task in cancer research. Our proposed method utilizes the Bidirectional Encoder Representations from Transformers (BERT) architecture,…

计算与语言 · 计算机科学 2023-06-08 Sultan Zavrak , Seyhmus Yilmaz

Cancer pathological analysis requires modeling tumor heterogeneity across multiple modalities, primarily through transcriptomics and whole slide imaging (WSI), along with their spatial relations. On one hand, bulk transcriptomics and WSI…

机器学习 · 计算机科学 2026-03-17 Jingkun Yu , Guangkai Shang , Changtao Li , Xun Gong , Tianrui Li , Yazhou He , Zhipeng Luo

This study introduces a federated learning-based approach to predict HER2 status from hematoxylin and eosin (HE)-stained whole slide images (WSIs), reducing costs and speeding up treatment decisions. To address label imbalance and feature…

计算机视觉与模式识别 · 计算机科学 2024-12-20 Kamorudeen A. Amuda , Almustapha A. Wakili

Recent advances in image-text pretraining have significantly enhanced visual understanding by aligning visual and textual representations. Contrastive Language-Image Pretraining (CLIP) has played a pivotal role in multimodal learning.…

计算机视觉与模式识别 · 计算机科学 2026-02-20 Zihan Li , Yiqing Wang , Sina Farsiu , Paul Kinahan

Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosis…

计算机视觉与模式识别 · 计算机科学 2025-02-13 Xiaofei Wang , Hanyu Liu , Yupei Zhang , Boyang Zhao , Hao Duan , Wanming Hu , Yonggao Mou , Stephen Price , Chao Li

The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…

计算机视觉与模式识别 · 计算机科学 2025-03-19 Junjie Zhou , Jiao Tang , Yingli Zuo , Peng Wan , Daoqiang Zhang , Wei Shao

Transformer-based models have achieved remarkable success in natural language and vision tasks, but their application to gene expression analysis remains limited due to data sparsity, high dimensionality, and missing values. We present…

机器学习 · 计算机科学 2025-04-15 Shuai Jiang , Saeed Hassanpour

Pathological captioning of Whole Slide Images (WSIs), though is essential in computer-aided pathological diagnosis, has rarely been studied due to the limitations in datasets and model training efficacy. In this paper, we propose a new…

计算机视觉与模式识别 · 计算机科学 2023-11-01 Wenkang Qin , Rui Xu , Peixiang Huang , Xiaomin Wu , Heyu Zhang , Lin Luo

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of…

计算机视觉与模式识别 · 计算机科学 2025-05-21 Mingcheng Qu , Guang Yang , Donglin Di , Tonghua Su , Yue Gao , Yang Song , Lei Fan

Scene Graph Generation (SGG) aims to generate a comprehensive graphical representation that accurately captures the semantic information of a given scenario. However, the SGG model's performance in predicting more fine-grained predicates is…

计算机视觉与模式识别 · 计算机科学 2024-08-27 Jiasong Feng , Lichun Wang , Hongbo Xu , Kai Xu , Baocai Yin

Whole slide image (WSI) classification is a crucial problem for cancer diagnostics in clinics and hospitals. A WSI, acquired at gigapixel size, is commonly tiled into patches and processed by multiple-instance learning (MIL) models.…

计算机视觉与模式识别 · 计算机科学 2024-10-10 Doanh C. Bui , Jin Tae Kwak

Multi-label classification of chest X-ray images is frequently performed using discriminative approaches, i.e. learning to map an image directly to its binary labels. Such approaches make it challenging to incorporate auxiliary information…

人工智能 · 计算机科学 2021-03-11 Anjany Sekuboyina , Daniel Oñoro-Rubio , Jens Kleesiek , Brandon Malone