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Imputation is a popular approach to handling censored, missing, and error-prone covariates -- all coarsened data types for which the true values are unknown. However, there are nuances to imputing these different data types based on the…

统计方法学 · 统计学 2025-04-29 Sarah C. Lotspeich , Ethan M. Alt

Using the PreventS trial data, our objective is to estimate average effects of a Health Wellness Coaching (HWC) intervention on improvement of cardiovascular health at 9 months post randomization and in three consecutive 3-month periods…

统计方法学 · 统计学 2023-03-01 Jinghong Zeng

In biomedical studies, estimating drug effects on chronic diseases requires a long follow-up period, which is difficult to meet in randomized clinical trials (RCTs). The use of a short-term surrogate to replace the long-term outcome for…

统计方法学 · 统计学 2023-06-27 Wenjie Hu , Xiaohua Zhou , Peng Wu

Longitudinal observational patient data can be used to investigate the causal effects of time-varying treatments on time-to-event outcomes. Several methods have been developed for controlling for the time-dependent confounding that…

统计方法学 · 统计学 2021-10-08 Ruth H. Keogh , Jon Michael Gran , Shaun R. Seaman , Gwyneth Davies , Stijn Vansteelandt

Cluster-randomized trials (CRTs) involve randomizing entire groups of participants -- called clusters -- to treatment arms but are often comprised of a limited or fixed number of available clusters. While covariate adjustment can account…

统计方法学 · 统计学 2022-11-29 Angela Y. Zhu , Nandita Mitra , Karla Hemming , Michael O. Harhay , Fan Li

Tabular synthetic data generators are typically trained to match observational distributions, which can yield high conventional utility (e.g., column correlations, predictive accuracy) yet poor preservation of structural relations relevant…

机器学习 · 计算机科学 2026-03-03 Amir Asiaee , Zhuohui J. Liang , Chao Yan

Micro-randomized trials are commonly conducted for optimizing mobile health interventions such as push notifications for behavior change. In analyzing such trials, causal excursion effects are often of primary interest, and their estimation…

统计方法学 · 统计学 2024-08-19 Yihan Bao , Lauren Bell , Elizabeth Williamson , Claire Garnett , Tianchen Qian

There has recently been a growing interest in the development of statistical methods to compare medical costs between treatment groups. When cumulative cost is the outcome of interest, right-censoring poses the challenge of informative…

统计方法学 · 统计学 2017-05-25 Andrew J. Spieker , Arman Oganisian , Emily M. Ko , Jason A. Roy , Nandita Mitra

Marginal structural models (MSM) with inverse probability weighting (IPW) are used to estimate causal effects of time-varying treatments, but can result in erratic finite-sample performance when there is low overlap in covariate…

统计方法学 · 统计学 2019-07-16 Shirley Liao , Lucas Henneman , Corwin Zigler

For settings with a binary treatment and a binary outcome, instrumental variables can be used to construct bounds on a causal treatment effect. With continuous outcomes, meaningful bounds are more difficult to obtain because the domain of…

统计方法学 · 统计学 2013-03-26 Tao Liu , Joseph W. Hogan

Interference occurs when the treatment (or exposure) of one individual affects the outcomes of others. In some settings it may be reasonable to assume individuals can be partitioned into clusters such that there is no interference between…

统计方法学 · 统计学 2018-06-21 Lan Liu , Michael G. Hudgens , Bradley Saul , John D. Clemens , Mohammad Ali , Michael E. Emch

In observational studies, propensity scores are commonly estimated by maxi- mum likelihood but may fail to balance high-dimensional pre-treatment covariates even after specification search. We introduce a general framework that unifies and…

统计方法学 · 统计学 2017-03-22 Qingyuan Zhao

Unsupervised learning is often used to uncover clusters in data. However, different kinds of noise may impede the discovery of useful patterns from real-world time-series data. In this work, we focus on mitigating the interference of…

机器学习 · 统计学 2021-12-07 Irene Y. Chen , Rahul G. Krishnan , David Sontag

We consider missingness in the context of causal inference when the outcome of interest may be missing. If the outcome directly affects its own missingness status, i.e., it is "self-censoring", this may lead to severely biased causal effect…

统计方法学 · 统计学 2023-06-12 Jacob M Chen , Daniel Malinsky , Rohit Bhattacharya

In observational studies, covariate imbalance generates confounding, resulting in biased comparisons. Although propensity score-based weighting approaches facilitate unconfounded group comparisons for implicit target populations, existing…

统计方法学 · 统计学 2023-07-03 Subharup Guha , David C. Christiani , Yi Li

Weight averaging is a widely used technique for accelerating training and improving the generalization of deep neural networks (DNNs). While existing approaches like stochastic weight averaging (SWA) rely on pre-set weighting schemes, they…

机器学习 · 计算机科学 2025-02-11 Tao Li , Zhehao Huang , Yingwen Wu , Zhengbao He , Qinghua Tao , Xiaolin Huang , Chih-Jen Lin

In this paper, I try to tame "Basu's elephants" (data with extreme selection on observables). I propose new practical large-sample and finite-sample methods for estimating and inferring heterogeneous causal effects (under unconfoundedness)…

计量经济学 · 经济学 2023-01-20 Ganesh Karapakula

Background/aims: While randomized controlled trials are the gold standard for measuring causal effects, robust conclusions about causal relationships can be obtained using data from observational studies if proper statistical techniques are…

统计方法学 · 统计学 2021-12-10 Andreas Markoulidakis , Peter Holmans , Philip Pallmann , Monica Busse , Beth-Ann Griffin

Inverse probability of treatment weighting (IPTW) is a popular propensity score (PS)-based approach to estimate causal effects in observational studies at risk of confounding bias. A major issue when estimating the PS is the presence of…

Publication bias is a major concern in conducting systematic reviews and meta-analyses. Various sensitivity analysis or bias-correction methods have been developed based on selection models and they have some advantages over the widely used…

统计方法学 · 统计学 2021-09-28 Ao Huang , Kosuke Morikawa , Tim Friede , Satoshi Hattori