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Serving as an emerging and powerful tool, Large Language Model (LLM)-driven Human Digital Twins are showing great potential in healthcare system research. However, its actual simulation ability for complex human psychological traits, such…

人机交互 · 计算机科学 2025-12-11 Yuzhou Wu , Mingyang Wu , Di Liu , Rong Yin , Kang Li

Mechanistic learning, the synergistic combination of knowledge-driven and data-driven modeling, is an emerging field. In particular, in mathematical oncology, the application of mathematical modeling to cancer biology and oncology, the use…

定量方法 · 定量生物学 2023-12-13 John Metzcar , Catherine R. Jutzeler , Paul Macklin , Alvaro Köhn-Luque , Sarah C. Brüningk

Digital Twins (DTs) are becoming popular in Additive Manufacturing (AM) due to their ability to create virtual replicas of physical components of AM machines, which helps in real-time production monitoring. Advanced techniques such as…

计算机视觉与模式识别 · 计算机科学 2024-11-04 Md Manjurul Ahsan , Yingtao Liu , Shivakumar Raman , Zahed Siddique

Numerical simulations can model the physical processes that govern cardiovascular device deployment. When such simulations incorporate digital twins; computational models of patient-specific anatomy, they can expedite and de-risk the device…

计算机视觉与模式识别 · 计算机科学 2025-09-10 Karim Kadry , Shreya Gupta , Farhad R. Nezami , Elazer R. Edelman

Complex systems are not entirely decomposable, hence interdependences arise at the interfaces in complex projects. When changes occur, significant risks arise at these interfaces as it is hard to identify, manage and visualise the systemic…

系统与控制 · 电气工程与系统科学 2024-06-03 Jennifer Whyte , Ranjith Soman , Rafael Sacks , Neda Mohammadi , Nader Naderpajouh , Wei-Ting Hong , Ghang Lee

Digital twin technology has significant promise, relevance and potential of widespread applicability in various industrial sectors such as aerospace, infrastructure and automotive. However, the adoption of this technology has been slower…

机器学习 · 统计学 2020-06-16 Souvik Chakraborty , Sondipon Adhikari , Ranjan Ganguli

With the accelerating availability of multimodal surgical data and real-time computation, Surgical Digital Twins (SDTs) have emerged as virtual counterparts that mirror, predict, and inform decisions across pre-, intra-, and postoperative…

This paper discusses and explores the potential and relevance of recent developments in artificial intelligence (AI) and digital twins for health and well-being in low-resource African countries. We use the case of public health emergency…

人工智能 · 计算机科学 2023-07-11 Deshendran Moodley , Christopher Seebregts

The Digital Twins (DT) has quickly become a hot topic since it was proposed. It not only appears in all kinds of commercial propaganda, but also is widely quoted by academic circles. However, there are misstatements and misuse of the term…

计算工程、金融与科学 · 计算机科学 2022-03-25 Jiehan Zhou , Shouhua Zhang , Mu Gu

Artificial intelligence (AI) has sparked immense interest in drug discovery, but most current approaches only digitize existing high-throughput experiments. They remain constrained by conventional pipelines. As a result, they do not address…

计算机与社会 · 计算机科学 2025-07-29 You Wu , Philip E. Bourne , Lei Xie

This paper aims to provide a comprehensive critical overview on how entities and their interactions in Complex Networked Systems (CNS) are modelled across disciplines as they approach their ultimate goal of creating a Digital Twin (DT) that…

系统与控制 · 电气工程与系统科学 2022-02-22 Jiaqi Wen , Bogdan Gabrys , Katarzyna Musial

Optical communication is developing rapidly in the directions of hardware resource diversification, transmission system flexibility, and network function virtualization. Its proliferation poses a significant challenge to traditional optical…

网络与互联网体系结构 · 计算机科学 2020-11-11 Danshi Wang , Zhiguo Zhang , Min Zhang , Meixia Fu , Jin Li , Shanyong Cai , Chunyu Zhang , Xue Chen

Digital twin (DT) enables smart manufacturing by leveraging real-time data, AI models, and intelligent control systems. This paper presents a state-of-the-art analysis on the emerging field of DTs in the context of milling. The critical…

系统与控制 · 电气工程与系统科学 2025-12-16 Wenyi Liu , R. Sharma , W. "Grace" Guo , J. Yi , Y. B. Guo

The population of older adults is steadily increasing, with a strong preference for aging-in-place rather than moving to care facilities. Consequently, supporting this growing demographic has become a significant global challenge. However,…

计算机与社会 · 计算机科学 2025-04-08 Yongjie Wang , Jonathan Cyril Leung , Ming Chen , Zhiwei Zeng , Benny Toh Hsiang Tan , Yang Qiu , Zhiqi Shen

A Digital Twin is a virtual system that can fully describe a physical one. It constantly receives data from its counterpart's sensors, consults external sources, and obtains manual inputs from its stakeholders. The DT uses all this…

分布式、并行与集群计算 · 计算机科学 2023-01-02 Laura Bragante Corssac , Juliano Araujo Wickboldt

This paper presents a novel methodological framework, called the Actor-Simulator, that incorporates the calibration of digital twins into model-based reinforcement learning for more effective control of stochastic systems with complex…

机器学习 · 计算机科学 2025-01-07 Hua Zheng , Wei Xie , Ilya O. Ryzhov , Keilung Choy

Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital…

Radiopharmaceutical therapies are expanding rapidly, but clinical evidence generation is limited by operational constraints and biological heterogeneity in radiopharmaceutical delivery and radiation risk. Virtual theranostic trials can run…

Single-arm trials are an important study design for evaluating drug efficacy and safety without enrolling patients into a control arm. Although they do not provide the gold-standard evidence of randomized controlled trials, they are…

应用统计 · 统计学 2026-05-14 Daniele Bertolini , Franklin Fuller , Aaron M. Smith , Jonathan R. Walsh , Run Zhuang

Digital twin networks (DTNs) are real-time replicas of physical networks. They are emerging as a powerful technology for design, diagnosis, simulation, what-if-analysis, and artificial intelligence (AI)/machine learning (ML) driven…

网络与互联网体系结构 · 计算机科学 2022-12-06 Xingqin Lin , Lopamudra Kundu , Chris Dick , Emeka Obiodu , Todd Mostak