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Survival analysis is a type of semi-supervised ranking task where the target output (the survival time) is often right-censored. Utilizing this information is a challenge because it is not obvious how to correctly incorporate these censored…

机器学习 · 计算机科学 2018-06-12 Margaux Luck , Tristan Sylvain , Joseph Paul Cohen , Heloise Cardinal , Andrea Lodi , Yoshua Bengio

We address the problem of survival regression modelling with multivariate responses and nonlinear covariate effects. Our model extends the proportional hazards model by introducing several weakly-parametric elements: the marginal baseline…

统计方法学 · 统计学 2025-10-16 Na Lei , Mark A. Wolters , Wenqing He

Identifying and characterizing relationships between treatments, exposures, or other covariates and time-to-event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi-center clinical…

统计方法学 · 统计学 2025-04-02 Hillary M. Heiling , Naim U. Rashid , Quefeng Li , Xianlu L. Peng , Jen Jen Yeh

In this paper, we consider survival analysis with right-censored data which is a common situation in predictive maintenance and health field. We propose a model based on the estimation of two-parameter Weibull distribution conditionally to…

统计方法学 · 统计学 2020-02-24 Achraf Bennis , Sandrine Mouysset , Mathieu Serrurier

In observational studies of survival time featuring a binary time-dependent treatment, the hazard ratio (an instantaneous measure) is often used to represent the treatment effect. However, investigators are often more interested in the…

统计方法学 · 统计学 2020-05-21 Yun Li , Douglas E. Schaubel , Kevin He

This paper addresses the problem of identifying and estimating the causal effect of a treatment in the presence of unmeasured confounding and various types of right-censoring. Examples of these censoring mechanisms are administrative…

统计理论 · 数学 2025-03-19 Ilias Willems , Sara Rutten , Gilles Crommen , Ingrid Van Keilegom

The penalized profile sampler for semiparametric inference is an extension of the profile sampler method (Lee, Kosorok and Fine, 2005) obtained by profiling a penalized log-likelihood. The idea is to base inference on the posterior…

统计理论 · 数学 2007-06-13 Guang Cheng , Michael R. Kosorok

The proportional hazards (PH) model is arguably one of the most popular models used to analyze time to event data arising from clinical trials and longitudinal studies, among many others. In many such studies, the event time of interest is…

Many epidemiological and clinical studies aim at analyzing a time-to-event endpoint. A common complication is right censoring. In some cases, it arises because subjects are still surviving after the study terminates or move out of the study…

统计方法学 · 统计学 2024-01-10 Andrew Ying

Linear transformation model provides a general framework for analyzing censored survival data with covariates. The proportional hazards and proportional odds models are special cases of the linear transformation model. In biomedical…

统计方法学 · 统计学 2022-05-11 Sudheesh K. K. , Deemat C. Mathew , Litty Mathew , Min Xie

Introduction In analysis of time-to-event outcomes, a mixture cure (MC) model is preferred over a standard survival model when the sample includes individuals who will never experience the event of interest. Motivated by a cohort study of…

应用统计 · 统计学 2026-04-02 Changchang Xu , Laurent Briollais , Irene L Andrulis , Shelley B Bull

We describe a new approach to estimating relative risks in time-to-event prediction problems with censored data in a fully parametric manner. Our approach does not require making strong assumptions of constant proportional hazard of the…

机器学习 · 计算机科学 2021-06-10 Chirag Nagpal , Xinyu Rachel Li , Artur Dubrawski

Survival analysis is a fundamental tool for modeling time-to-event data in healthcare, engineering, and finance, where censored observations pose significant challenges. While traditional methods like the Beran estimator offer nonparametric…

机器学习 · 计算机科学 2025-06-13 Andrei V. Konstantinov , Vlada A. Efremenko , Lev V. Utkin

Semi-competing risks refers to the survival analysis setting where the occurrence of a non-terminal event is subject to whether a terminal event has occurred, but not vice versa. Semi-competing risks arise in a broad range of clinical…

统计方法学 · 统计学 2024-04-16 Harrison T. Reeder , Junwei Lu , Sebastien Haneuse

In population-based cohorts, disease diagnoses are typically censored by intervals as made during scheduled follow-up visits. The exact disease onset time is thus unknown, and in the presence of semi-competing risk of death, subjects may…

统计方法学 · 统计学 2025-08-25 Ariane Bercu , Agathe Guilloux , Cécile Proust-Lima , Hélène Jacqmin-Gadda

Non linear mixed effect models are classical tools to analyze non linear longitudinal data in many fields such as population Pharmacokinetic. Groups of observations are usually compared by introducing the group affiliations as binary…

统计计算 · 统计学 2017-09-28 Edouard Ollier , Adeline Samson , Xavier Delavenne , Vivian Viallon

The study of survival data often requires taking proper care of the censoring mechanism that prohibits complete observation of the data. Under right censoring, only the first occurring event is observed: either the event of interest, or a…

统计理论 · 数学 2025-03-25 Myrthe D'Haen , Ingrid Van Keilegom , Anneleen Verhasselt

The Mixture Cure (MC) models constitute an appropriate and easily interpretable method when studying a time-to-event variable in a population comprised of both susceptible and cured individuals. In literature, those models usually assume…

统计方法学 · 统计学 2024-12-10 Georgios Karakatsoulis

Frailty models are often the model of choice for heterogeneous survival data. A frailty model contains both random effects and fixed effects, with the random effects accommodating for the correlation in the data. Different estimation…

统计方法学 · 统计学 2019-09-17 Oodally Ajmal , Luc Duchateau , Estelle Kuhn

To better understand the interplay of censoring and sparsity we develop finite sample properties of nonparametric Cox proportional hazard's model. Due to high impact of sequencing data, carrying genetic information of each individual, we…

统计理论 · 数学 2019-07-31 Jelena Bradic , Rui Song