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Infectious diseases often involve multiple strains that interact through the immune response generated after an infection. This study investigates the conditions under which a two-strain epidemic model with partial cross-immunity can lead…

种群与进化 · 定量生物学 2024-12-11 Nir Gavish

We introduce a two-strain model with asymmetric temporary immunity periods and partial cross-immunity. We derive explicit conditions for competitive exclusion and coexistence of the strains depending on the strain-specific basic…

动力系统 · 数学 2023-06-28 Matthew D. Johnston , Bruce Pell , David A. Rubel

We investigate a discrete-time two-strain symbiotic epidemic model on complex networks with both random and long-range interactions. Our analysis examines how the co-infection recovery rate ($\mu$), the long-range decay exponent ($\alpha$),…

物理与社会 · 物理学 2025-09-23 Frank Namugera

Waning immunity and reinfection are critical features of many infectious diseases, but epidemiological models often fail to capture the intricate interaction between an individual's history of immunity and their current infection status;…

种群与进化 · 定量生物学 2026-03-25 Raimund M. Kovacevic , Nikolaos I. Stilianakis , Vladimir M. Veliov

The propagation of infectious diseases and its impact on individuals play a major role in disease dynamics, and it is important to incorporate population heterogeneity into efforts to study diseases. As a simplistic but illustrative…

种群与进化 · 定量生物学 2019-07-24 Juan G. Calvo , Alberto Hernández , Mason A. Porter , Fabio Sanchez

Between pandemics, the influenza virus exhibits periods of incremental evolution via a process known as antigenic drift. This process gives rise to a sequence of strains of the pathogen that are continuously replaced by newer strains,…

种群与进化 · 定量生物学 2020-08-18 Adam Griffin , Simon E. F. Spencer , Gareth O. Roberts

We consider the dynamics of a virus spreading through a population that produces a mutant strain with the ability to infect individuals that were infected with the established strain. Temporary cross-immunity is included using a time delay,…

种群与进化 · 定量生物学 2023-02-16 Bruce Pell , Samantha Brozak , Tin Phan , Fuqing Wu , Yang Kuang

We study how the interplay between the memory immune response and pathogen mutation affects epidemic dynamics in two related models. The first explicitly models pathogen mutation and individual memory immune responses, with contacted…

混沌动力学 · 物理学 2009-11-07 Michelle Girvan , Duncan S. Callaway , M. E. J. Newman , Steven H. Strogatz

Multi-strain competition on networks is observed in many contexts, including infectious disease ecology, information dissemination or behavioral adaptation to epidemics. Despite a substantial body of research has been developed considering…

SIRS models capture transmission dynamics of infectious diseases for which immunity is not lifelong. Extending these models by a W compartment for individuals with waning immunity, the boosting of the immune system upon repeated exposure…

种群与进化 · 定量生物学 2022-01-19 Richmond Opoku-Sarkodie , Ferenc A. Bartha , Mónika Polner , Gergely Röst

We investigate a time-delayed epidemic model for multi-strain diseases with temporary immunity. In the absence of cross-immunity between strains, dynamics of each individual strain exhibits emergence and anni- hilation of limit cycles due…

适应与自组织系统 · 物理学 2018-05-21 Larissa Bauer , Jason Bassett , Philipp Hövel , Yuliya N. Kyrychko , Konstantin B. Blyuss

We develop a stochastic two-patch epidemic model with nonlinear recidivism to investigate infectious disease dynamics in heterogeneous populations. Extending a deterministic framework, we introduce stochasticity to account for random…

种群与进化 · 定量生物学 2024-05-21 Juan G. Calvo , Mario I. Simoy , Juan P. Aparicio , José E. Chacón , Fabio Sanchez

In ecological systems heterogeneous interactions between pathogens take place simultaneously. This occurs, for instance, when two pathogens cooperate, while at the same time multiple strains of these pathogens co-circulate and compete.…

种群与进化 · 定量生物学 2025-05-05 Francesco Pinotti , Fakhteh Ghanbarnejad , Philipp Hövel , Chiara Poletto

In this paper we consider a competition system in which two diseases spread by contact. We characterize the system behavior, establishing that only some configurations are possible. In particular we discover that coexistence of the two…

动力系统 · 数学 2014-04-06 Roberto Cavoretto , Simona Collino , Bianca Giardino , Ezio Venturino

A simple, but ``classical``, stochastic model for epidemic spread in a finite, but large, population is studied. The progress of the epidemic can be divided into three different phases that requires different tools to analyse. Initially the…

种群与进化 · 定量生物学 2018-05-29 Åke Svensson

Starting from common assumptions, we build a rate equation model for multi-strain disease dynamics in terms of immune repertoire classes. We then move to a strain-level description where a low-order closure reminiscent of a pair…

种群与进化 · 定量生物学 2014-04-09 Tomás Aquino , Diogo Bolster , Ana Nunes

We investigate a two-strain disease model with amplification to simulate the prevalence of drug-susceptible (s) and drug-resistant (m) disease strains. We model the emergence of drug resistance as a consequence of inadequate treatment, i.e.…

种群与进化 · 定量生物学 2019-08-22 Md Abdul Kuddus , Michael T. Meehan , Adeshina I. Adekunle , Lisa J. White , Emma S. McBryde

When an infectious disease propagates throughout society, the incidence function may rise at first due to an increase in pathogenicity and then decrease due to inhibitory effects until it reaches saturation. Effective vaccination and…

动力系统 · 数学 2023-07-11 Sushil Pathak , G. Shirisha , K. Venkata Ratnam

The spread of infectious disease and the evolution of antigenically distinct strains are often modeled separately, despite strong feedbacks mediated by host immune memory and heterogeneous contacts. To tackle this challenging problem, we…

种群与进化 · 定量生物学 2026-04-01 Davide Zanchetta , Vittoria Bettio , Sandro Azaele , Manlio De Domenico

Coinfection phenomena are common in nature, yet there is a lack of analytical approaches for coinfection systems with a high number of circulating and interacting strains. In this paper, we investigated a coinfection SIS framework applied…

种群与进化 · 定量生物学 2026-02-06 Sten Madec , Nicola Cinardi , Erida Gjini
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