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In this paper we address the challenges posed by non-proportional hazards and informative censoring, offering a path toward more meaningful causal inference conclusions. We start from the marginal structural Cox model, which has been widely…

统计方法学 · 统计学 2023-11-15 Jiyu Luo , Denise Rava , Jelena Bradic , Ronghui Xu

The Cox regression, a semi-parametric method of survival analysis, is extremely popular in biomedical applications. The proportional hazards assumption is a key requirement in the Cox model. To accommodate non-proportional hazards, we…

统计方法学 · 统计学 2022-06-13 Alexander Begun , Elena Kulinskaya

In observational studies with survival or time-to-event outcomes, a propensity score weighted marginal Cox proportional hazard model with the treatment variable as the only predictor is commonly used to estimate the causal marginal hazard…

统计方法学 · 统计学 2026-02-02 Zixian Zhao , Chengxin Yang , Fan Li

Cox proportional hazard regression model is a popular tool to analyze the relationship between a censored lifetime variable with other relevant factors. The semi-parametric Cox model is widely used to study different types of data arising…

统计方法学 · 统计学 2018-10-09 Abhik Ghosh , Ayanendranath Basu

The problem of how to best select variables for confounding adjustment forms one of the key challenges in the evaluation of exposure effects in observational studies, and has been the subject of vigorous recent activity in causal inference.…

统计方法学 · 统计学 2021-12-02 Kelly Van Lancker , Oliver Dukes , Stijn Vansteelandt

Missing data is frequently encountered in many areas of statistics. Propensity score weighting is a popular method for handling missing data. The propensity score method employs a response propensity model, but correct specification of the…

统计方法学 · 统计学 2024-03-28 Hengfang Wang , Jae Kwang Kim , Jeongseop Han , Youngjo Lee

We present a conformal inference method for constructing lower prediction bounds for survival times from right-censored data, extending recent approaches designed for more restrictive type-I censoring scenarios. The proposed method imputes…

统计方法学 · 统计学 2025-05-26 Matteo Sesia , Vladimir Svetnik

One of the most common ways researchers compare survival outcomes across treatments when confounding is present is using Cox regression. This model is limited by its underlying assumption of proportional hazards; in some cases, substantial…

应用统计 · 统计学 2021-02-02 Elizabeth A. Handorf , Marc Smaldone , Sujana Movva , Nandita Mitra

The proportional hazards assumption in the commonly used Cox model for censored failure time data is often violated in scientific studies. Yang and Prentice (2005) proposed a novel semiparametric two-sample model that includes the…

统计方法学 · 统计学 2012-06-06 Guoqing Diao , Donglin Zeng , Song Yang

Over the last five decades, we have seen strong methodological advances in survival analysis, mainly in two separate strands: One strand is based on a parametric approach that assumes some response distribution. More prominent, however, is…

统计方法学 · 统计学 2025-03-25 Sandra Siegfried , Bálint Tamási , Torsten Hothorn

In survival analysis, the lifetime under study is not always observed. In certain applications, for some individuals, the value of the lifetime is only known to be smaller or larger than some random duration. This framework represent an…

统计理论 · 数学 2020-02-25 Laurent Bordes , Maria Carmen Pardo , Christian Paroissin , Valentin Patilea

In this paper, we expand the methodology presented in Mertens et. al (2020, Biometrical Journal) to the study of life-time (survival) outcome which is subject to censoring and when imputation is used to account for missing values. We…

统计方法学 · 统计学 2021-05-06 Bart J. A. Mertens

Randomized clinical trials with time-to-event outcomes have traditionally used the log-rank test followed by the Cox proportional hazards (PH) model to estimate the hazard ratio between the treatment groups. These are valid under the…

统计方法学 · 统计学 2022-06-07 Jiyu Luo , Ronghui Xu

We describe a new approach to estimating relative risks in time-to-event prediction problems with censored data in a fully parametric manner. Our approach does not require making strong assumptions of constant proportional hazard of the…

机器学习 · 计算机科学 2021-06-10 Chirag Nagpal , Xinyu Rachel Li , Artur Dubrawski

Survival outcomes are common in comparative effectiveness studies and require unique handling because they are usually incompletely observed due to right-censoring. A ``once for all'' approach for causal inference with survival outcomes…

统计方法学 · 统计学 2021-12-21 Shuxi Zeng , Fan Li , Liangyuan Hu , Fan Li

Our objective is to construct well-calibrated prediction sets for a time-to-event outcome subject to right-censoring with guaranteed coverage. Inspired by modern conformal inference, our approach avoids the need for a well-specified…

统计方法学 · 统计学 2026-01-27 Rebecca Farina , Eric J. Tchetgen Tchetgen , Arun Kumar Kuchibhotla

We develop flexible multi-parameter regression survival models for interval censored survival data arising in longitudinal prospective studies and longitudinal randomised controlled clinical trials. A multi-parameter Weibull regression…

统计方法学 · 统计学 2019-01-29 Defen Peng , Gilbert MacKenzie , Kevin Burke

Doubly protected estimators are widely used for estimating the population mean of an outcome Y from a sample where the response is missing in some individuals. To compensate for the missing responses, a vector X of covariates is observed at…

统计方法学 · 统计学 2017-11-07 Julieta Molina , Mariela Sued , Marina Valdora , Víctor Yohai

This work presents the first large-scale neutral benchmark experiment focused on single-event, right-censored, low-dimensional survival data. Benchmark experiments are essential in methodological research to scientifically compare new and…

机器学习 · 统计学 2026-04-24 Lukas Burk , John Zobolas , Bernd Bischl , Andreas Bender , Marvin N. Wright , Raphael Sonabend

While analysing time-to-event data, it is possible that a certain fraction of subjects will never experience the event of interest and they are said to be cured. When this feature of survival models is taken into account, the models are…

统计方法学 · 统计学 2020-01-27 Khandoker Akib Mohammad , Yuichi Hirose , Budhi Surya , Yuan Yao
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